Dermal Cell News Volume 2.26 | Jul 18 2016

TOP STORY

UCLA Study Unlocks Key Mechanisms that Determine Acquired Resistance to Immunotherapy in Advanced Melanoma

Researchers have for the first time identified mechanisms that determine how advanced melanoma can become resistant to immune checkpoint inhibitors, a discovery that could lead to the development of new and improved treatments for the deadliest type of skin cancer. [Press release from Univeristy of California Los Angeles discussing online prepublication in The New England Journal of Medicine] Press Release | Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification During Skin Development

Investigators showed that the developing primary hair follicle functions as a niche required for Merkel cell specification. [PLoS Genet] Full Article

A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development

Scientists found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell morphogenesis by inducing Shh expression in early follicles. [PLoS Genet] Full Article

Improvement of Sclerodermatous Graft versus Host Disease in Mice by Niclosamide

Recent reports on the implication of STAT3 and of Wnt/β-catenin in fibrosis have prompted researchers to investigate the effects of the inhibition of both signaling pathways in a mouse model of sclerodermatous GvHD, using niclosamide an anthelmintic drug with well-defined safety profile. [J Invest Dermatol] Abstract

Analysis on Transglutaminase 1 and Its Substrates Using Specific Substrate Peptide in Cultured Keratinocytes

Transglutaminase 1 expressions and its substrate were induced in cultured keratinocytes at differentiation-stage specific manner. [Biochem Biophys Res Commun] Abstract

SKIN CANCERS & DISORDERS

Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer

Scientists present an analysis of the genetic architecture of normal adult skin from 470 genetically unique mice, demonstrating the effect of germline variants, skin tissue location, and perturbation by exogenous inflammation or tumorigenesis on gene signaling pathways. [Cell Rep] Full Article | Graphical Abstract

Tumor Hypoxia Promotes Melanoma Growth and Metastasis via High Mobility Group Box-1 and M2-Like Macrophages

Investigators showed that the damage-associated molecular pattern High-Mobility Group Box 1 protein is released by melanoma tumor cells as a consequence of hypoxia and promotes M2-like tumor-associated macrophage accumulation and an IL-10 rich milieu within the tumor. [Sci Rep] Full Article

IgG Subclass Switching and Clonal Expansion in Cutaneous Melanoma and Normal Skin

Researchers found evidence for IgG-expressing B cells, class switching and antibody maturation in normal and malignant skin and clonally-expanded antibodies in melanoma, supporting the involvement of mature B cells in cutaneous immunity. [Sci Rep] Full Article

ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma

Researchers assessed the underlying mechanism of PREX1 overexpression in human melanoma. [Mol Cancer Res] Abstract

Mangiferin, a Novel Nuclear Factor Kappa B-Inducing Kinase Inhibitor, Suppresses Metastasis and Tumor Growth in a Mouse Metastatic Melanoma Model

Investigators evaluated the effect of mangiferin on metastasis and tumor growth in a mouse metastatic melanoma model. [Toxicol Appl Pharmacol] Abstract

Epigenetic Control of Adult Stem Cell Function

The authors explore the effects of epigenetic dysregulation on adult stem cell function. [Nat Rev Mol Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Cipher Pharmaceuticals Announces Ozenoxacin Accepted for Review by Health Canada

Cipher Pharmaceuticals Inc. announced that its New Drug Submission for Ozenoxacin has been accepted for review by Health Canada. Ozenoxacin is a topical treatment proposed for use in adult and pediatric patients with impetigo, a highly contagious bacterial skin infection. [Cipher Pharmaceuticals Inc.] Press Release

Damon Runyon Cancer Research Foundation Awards over $4M to 10 Top Young Clinical Investigators

The Damon Runyon Cancer Research Foundation named seven new Damon Runyon Clinical Investigators at its Spring 2016 Clinical Investigator Award committee review. [Damon Runyon Cancer Research Foundation] Press Release

Policy: Five Cornerstones of a Global Bioeconomy

Bioscience leaders such as the European Union, Japan and the United States see expanding the bioeconomy as a means of reindustrializing and creating wealth. Emerging industrial economies such as China and India see biotechnology as a nascent field of innovation in which they can quickly compete. Brazil, South Africa and Malaysia are investing to add value to their vast biological resources. [Nature News] Editorial

NEW ICCSCE 2016: 18^th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

Visit our events page to see a complete list of events in the dermal cell community.

NEW Postdoctoral Researcher – Computational Biology (Helmholtz Association)

PhD Studentship – Epithelial Stem Cell Biology (Curtin University)

PhD Studentship – Quantitative Biology (University of Heidelberg)

Postdoctoral Fellow – Skin Carcinogenesis (Inserm)

PhD studentship – Dermal Cell Research (University of Southampton)

Postdoctoral Fellow – Modulation of Lipid Organization in the Skin Barrier (Leiden University)

Postdoctoral Research Position – Cytokine Research (Temple University Lewis Katz School of Medicine)

Postdoctoral Positions – Cell, Developmental & Cancer Biology (Oregon Health & Science University)

Postdoctoral Fellow – Tissue Regeneration (US Army Institute of Surgical Research)

Research Scientist – Hair Biophysics (L’Oreal)

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