Ex Vivo Expansion of Hematopoietic Stem/Progenitor Cells from Human Umbilical Cord Blood on Acellular Scaffolds Prepared from MS-5 Stromal Cell Line Acellular matrices were used as biological scaffolds for the lineage-specific expansion of magnetically sorted CD34+ cells and the results were evaluated by flow cytometry and colony-forming assays. [J Tissue Eng Regen Med] Abstract Impact of Storage Temperature and Processing Delays on Cord Blood Quality: Discrepancy between Functional In Vitro and In Vivo Assays Researchers evaluated the impact of preprocessing storage and temperature on recovery, viability, and functional differentiation capacities of hematopoietic progenitor cells. [Transfusion] Abstract Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplant Grafts Using Oncolytic Myxoma Virus Investigators demonstrated that ex vivo treatment with an oncolytic poxvirus called myxoma virus results in specific elimination of human myeloma cells by inducing rapid cellular apoptosis while fully sparing normal hematopoietic stem and progenitor cells. [Biol Blood Marrow Transplant] Abstract Oxygen Tension Modifies the ‘Stemness’ of Human Cord Blood-Derived Stem Cells Scientists investigated the effects of oxygen tension on the generation, proliferation and expression of stem cell marker genes, which could be critical during large-scale cell culture for clinical applications. [Cytotherapy] Abstract Deferasirox Exposure Induces Reactive Oxygen Species and Reduces Growth and Viability of Myelodysplastic Hematopoietic Progenitors The authors observed progressive, dose-dependent suppression of MDS progenitor proliferation in culture with deferasirox concentrations ranging from 5 μM to 20 μM. This effect was more pronounced in MDS compared to CD34+ progenitors isolated from umbilical cord blood or normal peripheral blood. [Leuk Res] Abstract Male Gender Promotes an Increased Inflammatory Response to Lipopolysaccharide (LPS) in Umbilical Vein Blood Researchers found that blood of male fetuses mounts a larger pro-inflammatory response to LPS. [J Matern Fetal Neonatal Med] Abstract Preeclampsia Serum Upregulates CD40/CD40L Expression and Induces Apoptosis in Human Umbilical Cord Endothelial Cells Researchers investigated the role of CD40/CD40L in the pathogenesis of preeclampsia (PE) by comparing the effect of maternal serum obtained from healthy pregnant women and PE patients on HUVEC cell growth, apoptosis and CD40/CD40L expression. [Reprod Biol Endocrinol] Abstract Osteogenic Potential of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Cultured with Umbilical Cord Blood-Derived Autoserum Researchers used autoserum derived from the umbilical cord blood of neonates in an attempt to examine the osteoblastic differentiation potential of umbilical cord-derived mesenchymal stromal cells in nude mice. [J Craniomaxillofac Surg] Abstract |