LABORATORY RESEARCH Thrombin Receptor Regulates Hematopoiesis and Endothelial-to-Hematopoietic Transition Investigators showed that thrombin receptor, a protease-activated G protein-coupled receptor required for vascular development, functions as a negative regulator during hematopoietic development. [Dev Cell] Abstract Cell-Nonautonomous Hedgehog Signaling Promotes Murine B Lymphopoiesis from Hematopoietic Progenitors Results suggest that activity of the hedgehog pathway within stromal cells promotes B lymphopoiesis in a cell-nonautonomous fashion. [Blood] Abstract Osteopontin Is a Prognostic Factor for Survival of Acute Myeloid Leukemia Patients Investigators analyzed the prognostic impact of osteopontin in acute myeloid leukemia. [Blood] Abstract Bid Protects the Mouse Hematopoietic System following Hydroxyurea-Induced Replicative Stress Scientists investigated the role of the BH3-only Bcl-2 family member Bid in the response of murine hematopoietic cells to long-term replicative stress induced by hydroxyurea. [Cell Death Differ] Abstract Direct Toll Like Receptor-Mediated Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Towards Macrophages Results show that hematopoietic stem and progenitor cells may be directly stimulated by Toll like receptor agonists in vivo, and that the engagement of these receptors induces differentiation towards macrophages. [Stem Cells] Abstract Role of Misfolded N-CoR Mediated Transcriptional Deregulation of Flt3 in Acute Monocytic Leukemia (AML)-M5 Subtype Researchers report that loss of nuclear receptor co-repressor (N-CoR)-mediated transcriptional control of Flt3 due to misfolding contributes to malignant growth in AML of the M5 subtype. [PLoS One] Abstract Allogeneic Bone Marrow Grafts with High Levels of CD4+CD25+FoxP3+ T Cells Can Lead to Engraftment Failure Researchers showed that co-transplantation of bone marrow cells with high levels of regulatory CD4+CD25+FoxP3+ T cells leads to a 100% survival of mice and significantly accelerates the hematopoietic recovery. [Cytometry A] Abstract CLINICAL RESEARCH Cladribine, but Not Fludarabine, Added to Daunorubicin and Cytarabine during Induction Prolongs Survival of Patients with Acute Myeloid Leukemia: A Multicenter, Randomized Phase III Study Researchers evaluated whether the addition of a purine analog, cladribine or fludarabine, to the standard induction regimen affects the outcome of adult patients with acute myeloid leukemia. [J Clin Oncol] Abstract Ultra-Short Course Sirolimus Contributes to Effective GvHD Prophylaxis after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation A totaly of 37 patients underwent reduced-intensity conditioning allo-SCT after induction treatment with EPOCH-F(R) using a novel form of dual-agent immunosuppression for GvHD prophylaxis with CsA and sirolimus. [Bone Marrow Transplant] Abstract |