CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells Researchers report that quiescence exit kinetics are differentially regulated within human hematopoietic stem cell subsets through the expression level of CDK6. [Cell Stem Cell] Full Article | Graphical Abstract Restricted Dendritic Cell and Monocyte Progenitors in Human Cord Blood and Bone Marrow Scientists report a culture system that supports development of CD34+ hematopoietic stem cell progenitors into the three major human dendritic cell subsets, monocytes, granulocytes, and NK and B cells. [J Exp Med] Abstract Primitive Macrophages Control HSPC Mobilization and Definitive Hematopoiesis The authors identified an unexpected primitive macrophage population accumulated in the dorsal mesenteric mesoderm surrounding the dorsal aorta of the human embryo and studied its function in the transparent zebrafish embryo. They revealed dynamic interactions occurring between hematopoietic stem/progenitor cells (HSPCs) and primitive macrophages in the aorta-gonad-mesonephros. [Nat Commun] Abstract Estrogen-Inducible sFRP5 Inhibits Early B-Lymphopoiesis In Vivo, but Not during Pregnancy Scientists showed that estrogen-induced soluble Frizzled-related proteins (sFRPs), and particularly sFRP5, suppress B-lymphopoiesis in vivo in transgenic mice. sFRP5 deficiency reduced the number of hematopoietic stem cells and primitive lymphoid progenitors in the bone marrow, particularly when estrogen was administered. [Eur J Immunol] Abstract Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells Expression deletion of Hiwi, a human Piwi homolog, has been reported to be implicated in leukemogenesis. Researchers explored Hiwi’s role in chronic myeloid leukemia (CML) pathogenesis by determining how and whether its forced overexpression could affect CML cell growth and migration. [Cell Biochem Biophys] Abstract CLINICAL RESEARCH Phase I/II Study of the Combination of Panobinostat and Carfilzomib in Patients with Relapsed/Refractory Multiple Myeloma Investigators assessed the safety and efficacy of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma. [Haematologica] Abstract | Full Article Haploidentical Hematopoietic Stem Cell Transplantation without In Vitro T-Cell Depletion for the Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Researchers investigated the long-term survival of Philadelphia chromosome-positive acute lymphoblastic leukemia patients who underwent haploidentical donor hematopoietic stem cell transplantation (HSCT) and analyzed the factors influencing relapse and survival after allogeneic HSCT. [Biol Blood Marrow Transplant] Abstract Effect of ATG-F on B Cell Reconstitution after Hematopoietic Stem Cell Transplantation Little is known about the effect of antithymocyte globulin Fresenius (ATG-F) on the reconstitution of B cell subsets. 67 patients were longitudinally studied at day 15, day 30 and then monthly after hematopoietic stem cell transplantation. [Eur J Haematol] Abstract |