SCIENCE NEWS New Model Tracks the Immune Response to a T Using T cells primed for the infectious disease toxoplasmosis, Whitehead Institute researchers have created novel mouse models of the immune system that more accurately reflect how immune cells actually respond to pathogens in their presence. [Press release from Whitehead Institute for Biomedical Research discussing online prepublication in Science] The Immune System’s Guard Against Cancer Researchers have discovered how beta-interferon can inhibit tumour growth. [Press release from Helmholtz Center for Infection Research discussing online prepublication in Journal of Clinical Investigation] BUSPH Study Links Rheumatoid Arthritis To Vitamin D Deficiency Women living in the northeastern United States are more likely to develop rheumatoid arthritis, suggesting a link between the autoimmune disease and vitamin D deficiency, says a new study. [Press release from Biocompare discussing online prepublication in Environmental Health Perspectives]
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CURRENT PUBLICATIONS Transnuclear Mice with Predefined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT Using epigenetic reprogramming via somatic cell nuclear transfer (SCNT), researchers demonstrated that T cells with predefined specificities against Toxoplasma gondii can be used to generate mouse models that express the T cell receptor from their endogenous loci, without experimentally introduced genetic modification. [Science] The Transcription Factor c-Myb Primes CD4+CD8+ Immature Thymocytes for Selection Into the iNKT Lineage Here researchers show that the transcription factor c-Myb has a central role in priming double-positive (DP) thymocytes to enter the iNKT lineage by simultaneously regulating CD1d expression, the half-life of DP cells and expression of SLAMF1, SLAMF6 and SAP. [Nat Immunol] The Zinc-Finger Protein MAZR is Part of the Transcription Factor Network that Controls the CD4 Versus CD8 Lineage Fate of Double-Positive Thymocytes MAZR is part of the transcription factor network that regulates the CD8 lineage differentiation of double-positive thymocytes. [Nat Immunol] E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis Here, researchers show that monocyte-derived inflammatory dendritic cells that express E-cadherin, the receptor for CD103, promote intestinal inflammation. [Immunity] Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins These results provide an indirect mechanism of cross-inhibition of toll-like receptors and delineate a signaling pathway important for deactivation of macrophages. [ Immunity] A Defunctioning Polymorphism in FCGR2B is Associated with Protection Against Malaria but Susceptibility to Systemic Lupus Erythematosus Researchers show that a single-nucleotide polymorphism in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to systemic lupus erythematosus in both Caucasians and Southeast Asians. [Proc Natl Acad Sci U S A] T and B Cell Hyperactivity and Autoimmunity Associated with Niche-Specific Defects in Apoptotic Body Clearance in TIM-4-Deficient Mice In this study, researchers describe the generation of TIM-4-deficient mice and address whether TIM-4 serves a unique function in vivo. [Proc Natl Acad Sci U S A] TGF-Beta Enhances Effector Th1 Cell Activation but Promotes Self-Regulation Via IL-10 Using myelin-specific T cell receptor transgenic mice, researchers demonstrate that TGF-beta elicits differential effects on naive versus effector Th1 cells. [J Immunol] Anti-Inflammatory Activity of PYNOD and Its Mechanism in Humans and Mice In this study, researchers investigated the molecular mechanism of PYNOD’s anti-inflammatory activity in vitro and its expression and function in mice. [J Immunol] Activation of Murine Macrophages Via TLR2 and TLR4 Is Negatively Regulated by a Lyn/PI3K Module and Promoted by SHIP1 Researchers demonstrate in this study that the Src family kinase Lyn negatively regulates TLR signaling in murine bone marrow-derived macrophages and in vivo. [J Immunol] Association between Residences in U.S. Northern Latitudes and Rheumatoid Arthritis: A Spatial Analysis of the Nurses’ Health Study The etiology of rheumatoid arthritis (RA) remains largely unknown although epidemiologic studies suggest genetic and environmental factors may play a role. Geographic variation in incident RA has been observed at the regional level. [Environ Health Perspect]
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POLICY NEWS University of Chicago Physician Named to Presidential Commission for the Study of Bioethical Issues Daniel Sulmasy, MD, PhD, the Kilbride-Clinton Professor of Medicine and Ethics in the Department of Medicine and the Divinity School, and Associate Director of the MacLean Center for Clinical Medical Ethics at the University of Chicago, has been named to the Presidential Commission for the Study of Bioethical Issues. [Presidential Commission for the Study of Bioethical Issues, United States] National Human Genome Research Institute Names New Chief of Genome Technology Branch The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, has named Lawrence C. Brody, Ph.D., as the new chief of its Genome Technology Branch, the largest of seven branches in the NHGRI Division of Intramural Research. [National Institutes of Health, United States] Minor Use Minor Species Development of Drugs; Research Project Grant (R01) (RFA-FD-10-001) [National Institutes of Health, United States] Bioengineering Nanotechnology Initiative [STTR (R41/R42)] (PA-10-149) [National Institutes of Health, United States] Bioengineering Nanotechnology Initiative [SBIR (R43/R44)] (PA-10-150) [National Institutes of Health, United States] Clinical Investigator Status (Biologics) [Food and Drug Administration, United States] Background on Study Results of U.S. Academic Researchers [Food and Drug Administration, United States] Secretary Sebelius Announces Five New Health and Human Services Regional Directors [Department of Health & Human Services, United States]
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EVENTS American Association for Cancer Research (AACR) 101st Annual Meeting 2010 April 17-21, 2010 Washington, DC, United States 23rd Annual Canadian Society for Immunology (CSI) Conference April 23-26, 2010 Niagara Falls, Canada 97th Annual Meeting of the American Association of Immunologists (AAI) May 7-11, 2010 Baltimore, United States 29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI) June 5-9, 2010 London, United Kingdom Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3) June 7-12, 2010 Dublin, Ireland Federation of Clinical Immunology Societies (FOCIS) 2010 June 24-27, 2010 Boston, United States Frontiers in Immunology Research (FIRN) 2010 International Conference July 22-26, 2010 Athens, Greece 14th International Congress of Immunology August 22-27, 2010 Kobe, Japan Select BioSciences 7th Annual RNAi & miRNA Europe September 14-15, 2010 Dublin, Ireland 5th International Conference on Gene Regulation in Lymphocyte Development October 9-14, 2010 Chania, Greece Autumn Immunology Conference 2010 November 19-22, 2010 Chicago, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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