CURRENT PUBLICATIONS Temporal Changes in Dendritic Cell Subsets, Cross-Priming and Costimulation Via CD70 Control CD8+ T Cell Responses to Influenza Researchers show here that influenza-specific CD8+ T cell priming was controlled by different dendritic cells at different times after infection. [Nat Immunol] Natural Killer Cells Expressing Inhibitory Killer Cell Immunoglobulin-Like Receptors for Non-Self Ligands Remain Tolerant in HLA-Matched Sibling Stem Cell Transplantation This study provides evidence against the emergence of alloreactive natural killer cells in HLA-identical allogeneic stem cell transplantation. [Blood] Evidence for a Functional Role of IgE Anticitrullinated Protein Antibodies in Rheumatoid Arthritis Exposure to citrullinated antigens leads to activation of basophils from anticitrullinated protein antibodies plus rheumatoid arthritis patients within 20 minutes. [PNAS] Intracellular Major Histocompatibility Complex Class II Controls Regulatory Tolerance to Allogeneic Transplants Results demonstrated the key role of major histocompatibility complex II in the induction of regulatory T cells. [J Immunol] Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced Toll-Like Receptor-Dependent Interferon-Beta Production Researchers have identified the inositol 5′ phosphatase SHIP-1 as a negative regulator of toll-like receptor 3-induced type I interferon production. [J Immunol] Phospholipase C Gamma 2 Is Critical for Development of a Murine Model of Inflammatory Arthritis by Affecting Actin Dynamics in Dendritic Cells This study demonstrates a critical role for phospholipase C gamma 2 in eliciting inflammatory responses by regulating actin dynamics in dendritic cells and positions the phospholipase C gamma 2 pathway as a common orchestrator of bone and immune cell functions during arthritis. [PLoS One] Alpha-1,2-Mannosidase and Hence N-Glycosylation Are Required for Regulatory T Cell Migration and Allograft Tolerance in Mice Researchers have identified that alpha-1,2-mannosidase expression increases in CD25+CD4+ regulatory T cells when they encounter alloantigen in vivo. [PLoS One] Specific Gene Expression Signature Associated with Development of Autoimmune Type I Diabetes Using Whole-Blood Microarray Analysis Results showed the presence of early functional modifications associated with type I diabetes, which could help to understand the disease and suggest possible avenues for therapeutic interventions. [Genes Immun]
|