Immune Regulation News Volume 2.03 | Jan 29 2010

Study Reveals Unexpected Function for Seemingly Redundant Protein
Researchers have discovered the critical importance of TAB2, a protein previously believed to be a redundant "on switch" for certain immune-system responses. [North Carolina State University, Raleigh]

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Biochemist Brian Baker Publishes Research on Protein Dynamics
A discovery at the University of Notre Dame reveals the importance of dynamic motion by proteins involved in the body’s immune response. [University of Notre Dame, Notre Dame]

New Therapeutic Approach Identified for Kidney Disease Associated With Lupus
Investigators have identified a new disease mechanism and therapeutic approach for a type of advanced kidney disease that is a common cause of complications in patients with lupus. [Hospital for Special Surgery, New York]

Temporal Changes in Dendritic Cell Subsets, Cross-Priming and Costimulation Via CD70 Control CD8+ T Cell Responses to Influenza
Researchers show here that influenza-specific CD8+ T cell priming was controlled by different dendritic cells at different times after infection. [Nat Immunol]

Natural Killer Cells Expressing Inhibitory Killer Cell Immunoglobulin-Like Receptors for Non-Self Ligands Remain Tolerant in HLA-Matched Sibling Stem Cell Transplantation
This study provides evidence against the emergence of alloreactive natural killer cells in HLA-identical allogeneic stem cell transplantation. [Blood]

Evidence for a Functional Role of IgE Anticitrullinated Protein Antibodies in Rheumatoid Arthritis
Exposure to citrullinated antigens leads to activation of basophils from anticitrullinated protein antibodies plus rheumatoid arthritis patients within 20 minutes. [PNAS]

Intracellular Major Histocompatibility Complex Class II Controls Regulatory Tolerance to Allogeneic Transplants
Results demonstrated the key role of major histocompatibility complex II in the induction of regulatory T cells. [J Immunol]

Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced Toll-Like Receptor-Dependent Interferon-Beta Production
Researchers have identified the inositol 5′ phosphatase SHIP-1 as a negative regulator of toll-like receptor 3-induced type I interferon production. [J Immunol]

Phospholipase C Gamma 2 Is Critical for Development of a Murine Model of Inflammatory Arthritis by Affecting Actin Dynamics in Dendritic Cells
This study demonstrates a critical role for phospholipase C gamma 2 in eliciting inflammatory responses by regulating actin dynamics in dendritic cells and positions the phospholipase C gamma 2 pathway as a common orchestrator of bone and immune cell functions during arthritis. [PLoS One]

Alpha-1,2-Mannosidase and Hence N-Glycosylation Are Required for Regulatory T Cell Migration and Allograft Tolerance in Mice
Researchers have identified that alpha-1,2-mannosidase expression increases in CD25+CD4+ regulatory T cells when they encounter alloantigen in vivo. [PLoS One]

Specific Gene Expression Signature Associated with Development of Autoimmune Type I Diabetes Using Whole-Blood Microarray Analysis
Results showed the presence of early functional modifications associated with type I diabetes, which could help to understand the disease and suggest possible avenues for therapeutic interventions. [Genes Immun]

Osiris Completes Enrollment in Stem Cell Trial for Type 1 Diabetes
Osiris Therapeutics, Inc. announced that it has achieved a $750,000 milestone payment from the Juvenile Diabetes Research Foundation for completing enrollment in a Phase II clinical trial evaluating Prochymal. [Osiris Therapeutics, Inc., Press Release]

Sanford Donates $50 Million for Biomedical Research
South Dakota banking mogul Denny Sanford has donated $50 million more to the Burnham Medical Research Institute in San Diego, California, which will be renamed the Sanford-Burnham Institute in honor of the gift. [Science]

Advisory Committees; Tentative Schedule of Meetings for 2010 [Food and Drug Administration, United States]

Clarification of SF424 (R&R) Application Instructions for Resubmissions of Revision and Renewal Applications (NOT-OD-10-052) [National Institutes of Health, United States]

NINDS Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows in MD-PhD programs (F31) (PAR-10-091) [National Institutes of Health, United States]

Notice of Availability of Administrative Supplements for Activities to Promote Research Collaborations for Projects Currently Funded by the NCI Division of Cancer Biology (NOT-CA-10-015) [National Cancer Institute, United States]

Participation of NCCAM on RFA-OD-10-009, Recovery Act Limited Competition: Methodology Development in Comparative Effectiveness Research (RC4) (NOT-AT-10-001) [National Center for Complementary and Alternative Medicine, United States]

9th International Conference on New Trends in Immunosuppression and Immunotherapy
February 4-6, 2010
Geneva, Switzerland

13th International Conference on Lymphocyte Activation and Immune Regulation: Inflammasome and Inflammation
February 5-7, 2010
Newport Beach, United States

Keystone Symposia: Tolerance and Autoimmunity
February 21-26, 2010
Taos, United States

World Immune Regulation Meeting – IV
March 29-April 1, 2010
Davos, Switzerland

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

IMMUNOLOGY 2010
May 7-11, 2010
Baltimore, United States

14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan

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