Immune Regulation News 8.20 June 3, 2016 | |
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TOP STORYCalcium Signals Balance the Body’s Response to Infection Against Potential for Self-Attack Researchers found that a certain type of calcium-based signal regulated the production of two immune cell types: T follicular helper cells that drive the body’s massive reaction to invading organisms, and T follicular regulatory cells, which ramp that reaction down as soon as infection is finished. [Press release from NYU Langone Medical Center discussing online prepublication in Immunity] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation Investigators showed that cholesterol bound to the T cell receptor (TCR)β transmembrane region keeps the TCR in a resting, inactive conformation that cannot be phosphorylated by active kinases. [Immunity] Abstract | Graphical Abstract | Press Release Investigators analyzed 46 fresh lymph node biopsy samples including follicular lymphoma, diffuse large B cell lymphoma, classical Hodgkin lymphoma and reactive lymphadenitis. [Cancer Res] Abstract Foxp3 Is a Key Downstream Regulator of p53-Mediated Cellular Senescence Researchers report a novel function of the forkhead transcription factor Foxp3, which is a key player in mediating T-cell inhibitory functions, in p53-mediated cellular senescence. [Oncogene] Abstract Through a comparative analysis of regulatory T and IL-10-producing type 1 regulatory T (Tr1) cells, investigators hypothesized that Tr1 cells enhance the immunoregulatory functions of mesenchymal stem cells, and that a combinatorial approach to cell therapy may exert synergistic immunomodulatory effects in an experimental animal model of rheumatoid arthritis. [Sci Rep] Full Article Researchers investigated the proportion and activation status of peripheral immune regulatory cells and CD8+ T cell subsets in patients with head and neck squamous cell carcinoma using a multicolor flow cytometer, and then evaluated how docetaxel, cisplatin, and 5-fluorouracil therapy modulated the immune cell profile in peripheral blood. [Cancer Sci] Abstract Poly(lactide-co-glycolide) nanoparticles (PLGA NPs) were surface-modified with a TNFα mimicking peptide, and encapsulated soluble Leishmania antigens and MPLA adjuvant. The synthesized PLGA NPs exhibited low cytotoxicity levels, while surface-modified NPs were more efficiently taken up by dendritic cells (DCs). [Eur J Pharm Biopharm] Abstract Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys To assess the relationship between the turnover of CD4+ subsets and immunological homeostasis during simian immunodeficiency virus (SIV) infection in non-progressive hosts, investigators treated six SIV-uninfected and nine SIV-infected sooty mangabeys with 2′-bromo-5′-deoxyuridine for 14 days and longitudinally assessed CD4+ T-cell subset turnover by polychromatic flow cytometry. [PLoS One] Full Article Serologic tolerance to one such antigen, La/SS-B (La), is controlled by CD4+ T cells. Researchers investigated peripheral tolerance to human La (hLa) by tracking the fate of hLa-specific CD4+ T cells expressing the transgenic 3B5.8 T cell receptor after adoptive transfer into lymphocyte-replete recipient mice expressing hLa as a neo-self antigen. [Clin Exp Immunol] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSmTOR Inhibitors Effects on Regulatory T Cells and on Dendritic Cells Two main immunologic cell populations have been reported to play a central role in this setting: regulatory T cells (Tregs) and dendritic cells (DCs). The authors focus on the mammalian target of rapamycin (mTOR) inhibitors effects on Treg and DCs differentiation, activation, and function in the transplantation setting. [J Transl Med] Full Article Visit our reviews page to see a complete list of reviews in the immune regulation research field.
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SCIENCE NEWSAcetylon Pharmaceuticals, Inc. announced the publication of two abstracts describing preclinical studies that demonstrate the potential for histone deacetylase 6 inhibition with ricolinostat (ACY-1215) to augment immunotherapy approaches for the treatment of melanoma. [Press release from Acetylon Pharmaceuticals, Inc. (Business Wire) discussing research presented at 2016 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release | |
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INDUSTRY NEWSTxCell SA announces the signature of a strategic R&D collaboration agreement with the Lübeck Institute of Experimental Dermatology. This specific collaboration agreement covers the development of a CAR-regulatory T cells (Treg)-based cellular immunotherapy for bullous pemphigoid, a rare, potentially fatal autoimmune disease characterized by tense inflammatory skin blisters and in some patients, erosions on mucous membranes. [TxCell SA] Press Release Comprehensive Collaboration Agreement between Osaka University and Chugai Osaka University and Chugai Pharmaceutical Co., Ltd. announced the conclusion of a comprehensive collaboration agreement for advanced research in immunology between the Osaka University Immunology Frontier Research Center and Chugai. [Osaka University] Press Release
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EVENTSNEW 18th International Conference on Immunology (ICI) 2016 Visit our events page to see a complete list of events in the immune regulation community.
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JOB OPPORTUNITIESTechnical Sales Representative (STEMCELL Technologies Inc.) Research Technologist – T Cell Immunology (STEMCELL Technologies Inc.) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Scientist – Bioengineering (STEMCELL Technologies Inc.) Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Position – Transforming Growth Factor β on the Regulation of T Cell Response (Inserm) Postdoctoral Fellow – Immunology (New York University Medical Center) Faculty Positions – Microbiology and Immunology (National University of Singapore) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Immune Regulation News Volume 8.20 | Jun 3 2016