Immune Regulation News 9.38 October 6, 2017 | |
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TOP STORYFoxp3+ Tregs Are Recruited to the Retina to Repair Pathological Angiogenesis Investigators showed that retinopathy regulatory T cells are transiently increased in lymphoid organs and the retina, but decline when neovascularization is established. The decline is prevented following regulatory T cells expansion with an IL-2/anti-IL-2 mAb complex or the adoptive transfer of regulatory T cells. [Nat Commun] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)ICAMs Support B Cell Interactions with T Follicular Helper Cells and Promote Clonal Selection Scientists used in vivo B cell competition models and intravital imaging to examine the adhesive mechanisms governing B cell selection for germinal center colonization. They found that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate T follicular helper–B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion. [J Exp Med] Abstract Researchers found that naive TCF7 expression is FOXO1 independent, early postinfection they report bimodal, FOXO1-dependent expression of the memory-essential transcription factor TCF7 in pathogen-specific CD8+ T cells. [Proc Natl Acad Sci USA] Abstract The authors investigated the potential of CXCL12 inhibition by use of the clinical-stage L-RNA-aptamer NOX-A12 to increase the number of tumor-infiltrating lymphocytes. They used heterotypic tumor-stroma spheroids that mimic a solid tumor with a CXCL12-abundant TME. [Cancer Immunol Res] Abstract | Press Release | Full Article The authors showed that integrin alpha4 promotes immunosuppressive polarization of myeloid-derived suppressor cells and tumor-associated macrophages downstream of PI3Kγ, thereby inhibiting antitumor immunity. [Cancer Immunol Res] Abstract | Full Article Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity Researchers report that RORγt+ Treg cells were found in lymph nodes following immunization. Not only distinct from intestinal RORγt+ Treg cells in their transcriptomes, peripheral RORγt+ Treg cells were derived from Foxp3+ thymic Treg cells in an antigen-specific manner. [Cell Rep] Full Article | Graphical Abstract Spleen-Derived IFN-γ Induces Generation of PD-L1+-Suppressive Neutrophils during Endotoxemia Investigators demonstrated that, similar to what was found in humans, murine endotoxemia results in the influx of a subset of PD-L1+ neutrophils in the circulation, and incubation of mouse neutrophils with recombinant IFN-γ profoundly increases PD-L1 expression. [J Leukoc Biol] Abstract Scientists found that, in Jurkat T cells and in in vitro–differentiated Th17 cells, treatment with 2 HDAC inhibitors, butyrate and apicidin, led to the induction of the RORγT gene, which was associated with an increase in histone H4 acetylation near the RORγT proximal promoter. [J Leukoc Biol] Abstract DCs Facilitate B Cell Responses against Microbial DNA via DC-SIGN Researchers investigated the ability of dendritic cells (DCs) to bind and internalize extracellular E. coli DNA as well as synthetic DNA. [PLoS One] Full Article The authors examined the Th1 and Th17 responses toward several bacterial antigens, in CD4+ T cells sourced from the peripheral blood, the lung cancer tissue, and the gastrointestinal tract of non-small cell lung cancer patients. [Int Immunopharmacol] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSTargeting the Renin-Angiotensin System to Improve Cancer Treatment: Implications for Immunotherapy The authors review clinical data on the benefit of renin-angiotensin system inhibitors in primary and metastatic tumors and propose that, by activating immunostimulatory pathways, these inhibitors can enhance immunotherapy of cancer. [Sci Transl Med] Full Article Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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SCIENCE NEWSWindMIL Therapeutics presented its novel approach to harnessing a patient’s immune system to treat solid and liquid cancers. [Press release from WindMIL Therapeutics (Business Wire, Inc.) discussing research presented at The Cell & Gene Meeting on the Mesa, La Jolla] Press Release | |
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INDUSTRY NEWSSiamab Therapeutics, Inc. and Boehringer Ingelheim announced that they have entered into a strategic discovery collaboration with the goal of developing anti-cancer therapeutics targeting tumor associated carbohydrate antigens. [Siamab Therapeutics, Inc. (Business Wire, Inc.)] Press Release Selexis SA and Pelican Therapeutics announced that they have entered into a service agreement to advance the development of Pelican’s proprietary immunotherapy clinical candidates. [Selexis SA] Press Release The University of Texas MD Anderson Cancer Center and BridgeBio Pharma announced the launch of Navire Pharma, a biopharmaceutical company aimed at developing novel small-molecule inhibitors of a tyrosine-protein phosphatase called SHP2 for genetically driven and treatment-resistant cancer. [The University of Texas MD Anderson Cancer Center] Press Release | |
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POLICY NEWSNavajo Nation Reconsiders Ban on Genetic Research When the Navajo Nation opens its first oncology centre next year in Tuba City, Arizona, clinicians there may be able to offer a service that has been banned on tribal lands for 15 years: analyzing the DNA of Navajo tribe members to guide treatments and study the genetic roots of disease. [Nature News] Editorial Does Your State Get Its Fair Share of Federal Research Dollars? The only physicist in Congress has introduced a bill (H.R. 3763) that could rekindle a debate over how to deal with geographic disparities in the allocation of federal research funding. [ScienceInsider] Editorial Scientists Plead with Brazilian Government to Restore Funding Anxiety is growing in Brazil over the country’s collapsing research budgets. President Michel Temer had slashed funding for science by 44% in March and has proposed additional decreases for 2018 — even as some science institutes run out of money for basic needs, such as paying electricity bills. The 2017 science budget, at 3.2 billion reais (US$1 billion), is the lowest the country has seen in at least 12 years. [Nature News] Editorial Judge Recommends Ruling to Block Internet Access to Sci-Hub The American Chemical Society (ACS) brought a case against Sci-Hub, a pirate site providing access to scientific articles, for copyright and trademark infringement. Following a hearing at a court in Virginia, Magistrate Judge John Anderson filed a report that recommended ruling in favor of ACS on all counts. [The Scientist] Editorial
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EVENTSNEW Eradicate Cancer 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Tumor Immune Microenvironment (Columbia University) Research Technologist – Immunotherapy (STEMCELL Technologies Inc.) Scientist – Immunology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Immunology (University of Rochester Medical Center) Postdoctoral Fellow – Immunology (University of California, Los Angeles) Research Scientist – Immuno-Oncology (Kymab Ltd) Postdoctoral Researcher – Development of Immune System (Lund University) Postdoctoral Fellowship – Immunology (University of Georgia) Postdoctoral Research Fellows – Systems Immunology (University of Oslo) Postdoctoral Scholar – Regulation of Immune Responses (University of Iowa) Research Fellow Position – Immunology Research (ShanghaiTech University) Mouse Scientist – T Cell-Based Therapy (Tessa Therapeutics Pte Ltd.) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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