LABORATORY RESEARCH Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Induces Cancer Cell Senescence by Interacting with Telomerase RNA Component Researchers report that GAPDH interacts with the telomerase RNA component, inhibits telomerase activity, and induces telomere shortening and breast cancer cell senescence. [Proc Natl Acad Sci USA] Abstract RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Anti-Tumor Activities in Breast Cancer Scientists found that RKI-1447 inhibited migration, invasion and anchorage-independent tumor growth of breast cancer cells. RKI-1447 was highly effective at inhibiting the outgrowth of mammary tumors in a transgenic mouse model. [Cancer Res] Abstract Re-Expression of Tumor Suppressor, sFRP1, Leads to Anti-Tumor Synergy of Combined HDAC and Methyltransferase Inhibitors in Chemoresistant Cancers Researchers showed that addition of recombinant secreted frizzled-related protein one (sFRP1) to clear cell renal cell carcinomas or triple negative breast cancer cells inhibits cell growth in a dose-dependent manner through the induction of apoptosis, identifying that epigenetic silencing of sFRP1 contributes to renal and breast cancer cell survival. [Mol Cancer Ther] Abstract | Press Release Integrin Alpha2-Beta1 Mediates Tyrosine Phosphorylation of Vascular Endothelial Cadherin Induced by Invasive Breast Cancer Cells Scientists showed that the breast cancer cell induced disruption of endothelial adherens junction integrity is triggered by breast cancer cell alpha2/beta1 integrin and is mediated by HRas/myosin light chain-induced tyrosine phosphorylation of vascular endothelial cadherin. [J Biol Chem] Abstract | Full Article Cucurbitacin E Inhibits Breast Tumor Metastasis by Suppressing Cell Migration and Invasion The potency of cucurbitacin E on breast cancer metastasis inhibition was assessed in vivo and in vitro. [Breast Cancer Res Treat] Abstract Indole-3-Carbinol Disrupts Estrogen Receptor-Alpha Dependent Expression of Insulin-Like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and Proliferation of Human Breast Cancer Cells Researchers demonstrated in human MCF-7 breast cancer cells that indole-3-carbinol ablates expression of insulin-like growth factor receptor-1 (IGF1R) and insulin receptor substrate-1, downstream effectors of the IGF1 signaling pathway. [Mol Cell Endocrinol] Abstract Tumor Associated Macrophage x Cancer Cell Hybrids May Acquire Cancer Stem Cell Properties in Breast Cancer Results suggest that tumor-associated macrophages (TAMs) may promote breast cancer metastasis through cell fusion and that TAM and cancer cell hybrids may gain a breast cancer stem cell phenotype. [PLoS One] Full Article Correlation between Multi-Drug Resistance-Associated Membrane Transport in Clonal Cancer Cells and the Cell Cycle Phase Limited evidence has previously been reported on the cell cycle dependence of ABC transporter expression. However, it has never been demonstrated that the functional activity of these transporters correlates with the cell cycle position. Researchers studied the rate of intrinsic ABC transport in different phases of the cell cycle in cultured MCF-7 breast cancer cells. [PLoS One] Full Article Silibinin Inhibits Wnt/ß-Catenin Signaling by Suppressing Wnt Co-Receptor LRP6 Expression in Human Prostate and Breast Cancer Cells Researchers found that silibinin was able to suppress endogenous lipoprotein receptor-related protein-6 (LRP6) expression and phosphorylation and block Wnt/ß-catenin signaling in prostate cancer PC-3 and DU-145 cells and breast cancer MDA-MB-231 and T-47D cells. [Cell Signal] Abstract CLINICAL RESEARCH Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer Scientists found that a combination of anastrozole and fulvestrant was superior to anastrozole alone or sequential anastrozole and fulvestrant for the treatment of hormone-receptor-positive metastatic breast cancer, despite that the use of a dose of fulvestrant that was below the current standard. [N Engl J Med] Abstract | Press Release Overexpression of Activated Phospholipase Cγ1 Is a Risk Factor for Distant Metastases in T1-T2, N0 Breast Cancer Patients Undergoing Adjuvant Chemotherapy Researchers evaluated the association between the expression of phospholipase Cγ1 (PLCγ1), and of PLCγ1 phosphorylated at Tyr1253 and at Tyr783 with the clinical outcome of patients with node negative, T1/T2 breast cancers. [Int J Cancer] Abstract Obesity or Overweight Is Associated with Worse Pathological Response to Neoadjuvant Chemotherapy among Chinese Women with Breast Cancer Scientists evaluated the relationship between body mass index and response to neoadjuvant chemotherapy for breast cancer among Chinese women. [PLoS One] Full Article |