Mammary Cell News Volume 4.30 | Aug 2 2012

LABORATORY RESEARCH

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Induces Cancer Cell Senescence by Interacting with Telomerase RNA Component
Researchers report that GAPDH interacts with the telomerase RNA component, inhibits telomerase activity, and induces telomere shortening and breast cancer cell senescence. [Proc Natl Acad Sci USA] Abstract

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Anti-Tumor Activities in Breast Cancer
Scientists found that RKI-1447 inhibited migration, invasion and anchorage-independent tumor growth of breast cancer cells. RKI-1447 was highly effective at inhibiting the outgrowth of mammary tumors in a transgenic mouse model. [Cancer Res] Abstract

Re-Expression of Tumor Suppressor, sFRP1, Leads to Anti-Tumor Synergy of Combined HDAC and Methyltransferase Inhibitors in Chemoresistant Cancers
Researchers showed that addition of recombinant secreted frizzled-related protein one (sFRP1) to clear cell renal cell carcinomas or triple negative breast cancer cells inhibits cell growth in a dose-dependent manner through the induction of apoptosis, identifying that epigenetic silencing of sFRP1 contributes to renal and breast cancer cell survival. [Mol Cancer Ther] Abstract | Press Release

Integrin Alpha2-Beta1 Mediates Tyrosine Phosphorylation of Vascular Endothelial Cadherin Induced by Invasive Breast Cancer Cells
Scientists showed that the breast cancer cell induced disruption of endothelial adherens junction integrity is triggered by breast cancer cell alpha2/beta1 integrin and is mediated by HRas/myosin light chain-induced tyrosine phosphorylation of vascular endothelial cadherin. [J Biol Chem] Abstract | Full Article

Cucurbitacin E Inhibits Breast Tumor Metastasis by Suppressing Cell Migration and Invasion
The potency of cucurbitacin E on breast cancer metastasis inhibition was assessed in vivo and in vitro. [Breast Cancer Res Treat] Abstract

Indole-3-Carbinol Disrupts Estrogen Receptor-Alpha Dependent Expression of Insulin-Like Growth Factor-1 Receptor and Insulin Receptor Substrate-1 and Proliferation of Human Breast Cancer Cells
Researchers demonstrated in human MCF-7 breast cancer cells that indole-3-carbinol ablates expression of insulin-like growth factor receptor-1 (IGF1R) and insulin receptor substrate-1, downstream effectors of the IGF1 signaling pathway. [Mol Cell Endocrinol] Abstract

Tumor Associated Macrophage x Cancer Cell Hybrids May Acquire Cancer Stem Cell Properties in Breast Cancer
Results suggest that tumor-associated macrophages (TAMs) may promote breast cancer metastasis through cell fusion and that TAM and cancer cell hybrids may gain a breast cancer stem cell phenotype. [PLoS One] Full Article

Correlation between Multi-Drug Resistance-Associated Membrane Transport in Clonal Cancer Cells and the Cell Cycle Phase
Limited evidence has previously been reported on the cell cycle dependence of ABC transporter expression. However, it has never been demonstrated that the functional activity of these transporters correlates with the cell cycle position. Researchers studied the rate of intrinsic ABC transport in different phases of the cell cycle in cultured MCF-7 breast cancer cells. [PLoS One] Full Article

Silibinin Inhibits Wnt/ß-Catenin Signaling by Suppressing Wnt Co-Receptor LRP6 Expression in Human Prostate and Breast Cancer Cells
Researchers found that silibinin was able to suppress endogenous lipoprotein receptor-related protein-6 (LRP6) expression and phosphorylation and block Wnt/ß-catenin signaling in prostate cancer PC-3 and DU-145 cells and breast cancer MDA-MB-231 and T-47D cells. [Cell Signal] Abstract

CLINICAL RESEARCH

Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer
Scientists found that a combination of anastrozole and fulvestrant was superior to anastrozole alone or sequential anastrozole and fulvestrant for the treatment of hormone-receptor-positive metastatic breast cancer, despite that the use of a dose of fulvestrant that was below the current standard. [N Engl J Med] Abstract | Press Release

Overexpression of Activated Phospholipase Cγ1 Is a Risk Factor for Distant Metastases in T1-T2, N0 Breast Cancer Patients Undergoing Adjuvant Chemotherapy
Researchers evaluated the association between the expression of phospholipase Cγ1 (PLCγ1), and of PLCγ1 phosphorylated at Tyr1253 and at Tyr783 with the clinical outcome of patients with node negative, T1/T2 breast cancers. [Int J Cancer] Abstract

Obesity or Overweight Is Associated with Worse Pathological Response to Neoadjuvant Chemotherapy among Chinese Women with Breast Cancer
Scientists evaluated the relationship between body mass index and response to neoadjuvant chemotherapy for breast cancer among Chinese women. [PLoS One] Full Article

Targeting the Challenge of Multidrug Resistance in Breast and Lung Cancer by Developing Adva-27a
Sunshine Biopharma, Inc. (SBFM) report that the preclinical studies for Adva-27a were successfully completed. [Sunshine Biopharma, Inc.] Press Release

Stem Cell Agency Commits $150 Million to Develop New Therapies
California’s stem cell agency, the California Institute for Regenerative Medicine approved $150 million in new funding to help move promising stem cell-based therapies from the laboratory research phase to clinical trials in people. [California Institute for Regenerative Medicine] Press Release

UBC Project Examines the LGBT Experience with Breast and Gynecological Cancers
Researchers at the University of British Columbia (UBC) are leading the first nationwide project on how sexual and gender minorities experience cancer, highlighting previously overlooked communities’ perspectives on cancer care. [The University of British Columbia] Press Release

FDA Approves Afinitor for Advanced Breast Cancer
The U.S. Food and Drug Administration (FDA) approved Afinitor for use in combination with Aromasin to treat certain postmenopausal women with advanced hormone-receptor positive, HER2-negative breast cancer. [U.S. Food and Drug Administration] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW 9^th Annual School of Breast Oncology™
November 1-4, 2012
Atlanta, United States

NEW 8^th World Stem Cell Summit
December 3-5, 2012
West Palm Beach, United States

Visit our events page to see a complete list of events in the mammary cell community.

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Assistant Professor – Oncology/Breast Cancer (University of Chicago)

Associate Professor – Metastatic Breast Cancer (University of Colorado Comprehensive Cancer Center)

Postdoctoral Position – Breast Cancer (Albert Einstein College of Medicine)

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