Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells Researchers indicated that during an acute viral infection, cytotoxic CD8+ T cells indirectly modulate early multipotent hematopoietic progenitors via mesenchymal stromal cells in order to trigger the temporary activation of emergency myelopoiesis and promote clearance of the infection. [Cell Stem Cell] Abstract | Graphical Abstract Scaffold-Mediated Lentiviral Transduction for Functional Tissue Engineering of Cartilage Scientists showed that poly-L-lysine could immobilize lentivirus to poly(e-caprolactone) films and facilitate human mesenchymal stem cell (hMSC) transduction. They then demonstrated that scaffold-mediated gene delivery of transforming growth factor ß3, using a 3D woven poly(e-caprolactone) scaffold, induced robust cartilaginous extracellular matrix formation by hMSCs. [Proc Natl Acad Sci USA] Abstract | Press Release miR-142-3p Balances Proliferation and Differentiation of Mesenchymal Cells during Lung Development Investigators determined that miR-142-3p contributes to the proper proliferation of mesenchymal progenitors by controlling the level of WNT signaling. [Development] Abstract Low-Intensity Pulsed Ultrasound (LIPUS) Influences the Multi-Lineage Differentiation of Mesenchymal Stem and Progenitor Cell Lines through ROCK-Cot/Tpl2-MEK-ERK Signaling Pathway Researchers applied LIPUS to adipogenic progenitor cell and mesenchymal stem cell lines to analyze how multi-lineage cell differentiation was affected. [J Biol Chem] Abstract | Full Article Chondrogenically Differentiated Mesenchymal Stromal Cell Pellets Stimulate Endochondral Bone Regeneration in Critical-Sized Bone Defects Researchers determined if chondrogenically differentiated mesenchymal stromal cells pellets could induce bone regeneration in an orthotopic environment through endochondral ossification. [Eur Cell Mater] Abstract Cellular Reporter Systems for High-Throughput-Screening of Interactions between Bioactive Matrices and Human Mesenchymal Stromal Cells Researchers aimed at the identification of extracellular matrix components and candidate morphogens capable of enhancing the expression of hematopoietic stem cell-supportive proteins in human mesenchymal stromal cells, namely Angiopoietin-1 and stromal cell-derived factor 1. [Tissue Eng Part C Methods] Abstract Comparisons of Rabbit Bone Marrow Mesenchymal Stem Cell Isolation and Culture Methods In Vitro Isolated bone marrow mesenchymal stem cells were evaluated with respect to primary cell yield, number of CFU-F colonies, proliferative capacity, cell phenotype, and chondrogenic differentiation potential. [PLoS One] Full Article Umbilical Cord-Derived Mesenchymal Stem Cells Regulate Thymic Epithelial Cell Development and Function in Foxn1-/- Mice Scientists used human umbilical cord-derived mesenchymal stem cells to treat forkhead box n1 (Foxn1)-/- mice, and then analyzed the maturation and distribution of thymic epithelial cells in the Foxn1-/- thymic rudiment and the thymopoiesis of this newly developed rudiment. [Cell Mol Immunol] Abstract Adipose Stem Cells Used to Reconstruct 13 Cases with Cranio-Maxillofacial Hard-Tissue Defects Autologous adipose tissue was harvested from the anterior abdominal wall, and adipose-derived stem cells were cultured, expanded, and then seeded onto resorbable scaffold materials for subsequent reimplantation into hard-tissue defects. [Stem Cells Transl Med] Abstract Mesenchymal Stem Cells with Modification of Junctional Adhesion Molecule A Induce Hair Formation Scientists used human junctional adhesion molecule A-modified human mesenchymal stem cells to repair hair follicle abnormalities in BALB/c nu/nu mice. [Stem Cells Transl Med] Abstract |