Mesenchymal Cell News Volume 6.24 | Jun 24 2014

Non-Viral Oligonucleotide AntimiR-138 Delivery to Mesenchymal Stem Cell Sheets and the Effect on Osteogenesis
Investigators aimed to verify the feasibility of non-viral oligonucleotide delivery for the cell sheets and to confirm the osteogenesis enhancing effect of antimiR-138 on the cell sheets composed of bone marrow mesenchymal stem cells. [Biomaterials] Abstract

The IL-6-STAT3 Axis Mediates a Reciprocal Crosstalk between Cancer-Derived Mesenchymal Stem Cells and Neutrophils to Synergistically Prompt Gastric Cancer Progression
Researchers investigated the interaction between neutrophils and gastric cancer-derived mesenchymal stem cells (GC-MSCs) and explored the biological role of this interaction. They found that GC-MSCs induced the chemotaxis of neutrophils and protected them from spontaneous apoptosis. [Cell Death Dis] Full Article

Carbon Nanotube – Collagen Three-Dimensional Culture of Mesenchymal Stem Cells Promotes Expression of Neural Phenotypes and Secretion of Neurotrophic Factors
Scientists focused on carbon nanotubes dispersed within collagen hydrogels to provide three dimensional microenvironmental conditions for mesenchymal stem cells in stimulating biological functions for neural regeneration. [Acta Biomater] Abstract

Sequential Third-Party MSC Therapy for Refractory Acute Graft-versus-Host Disease
Researchers evaluated the feasibility, safety and efficacy of the administration of four sequential doses of cryopreserved bone marrow-derived mesenchymal stromal cells (MSC) expanded with platelet lysate and obtained from third-party donors as second line treatment for steroid refractory acute graft-versus-host disease in a series of 25 patients. [Biol Blood Marrow Transplant] Abstract

Tonsil-Derived Mesenchymal Stem Cells Alleviate Concanavalin A-Induced Acute Liver Injury
Intravenous administration of tonsil-derived mesenchymal stem cells (T-MSCs) significantly reduced concanavalin A-induced hepatic toxicity, but not acetaminophen-induced liver injury, affirming the immunoregulatory capacity of T-MSCs. [Exp Cell Res] Abstract

Secreted Adiponectin as a Marker to Evaluate In Vitro the Adipogenic Differentiation of Human Mesenchymal Stromal Cells
Scientists investigated whether it is possible to assess mesenchymal stromal cell adipogenic differentiation in a more efficient, timely and non-destructive manner, while monitoring in vitro secretion of adiponectin, a hormone specifically secreted by adipose tissue. [Cytotherapy] Abstract

Enhanced Proliferation and Differentiation of Oct4- and Sox2-Overexpressing Human Adipose Tissue Mesenchymal Stem Cells
Oct4/Sox2-overexpressing adipose tissue mesenchymal stem cells showed higher differentiation abilities for adipocytes or osteoblasts than controls. The markers of adipogenic or osteogenic differentiation were also upregulated by Oct4/Sox2 overexpression. [Exp Mol Med] Full Article

An Integrated Study of Natural Hydroxyapatite-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Using Transcriptomics, Proteomics and MicroRNA Analyses
Researchers combined transcriptomics, proteomics, and microRNA analyses to elucidate the mechanism of natural hydroxyapatite-induced osteogenic differentiation of mesenchymal stem cells. [Biomed Mater] Abstract

Sustained Expression of Coagulation Factor IX by Modified Cord Blood-Derived Mesenchymal Stromal Cells
Modification of human CB mesenchymal stromal cells with a lentiviral vector resulted in sustained high Factor IX expression in vitro following differentiation to adipogenic, chondrogenic and osteoblastic cells. [J Gene Med] Abstract

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Three Groundbreaking Biotech Startups Receive Funding from Peter Thiel’s Breakout Labs
EpiBone, based in the newly opened Harlem Biospace, uses computed tomography scans and fat-derived stem cells to engineer the patient’s own living bone with the precise anatomical fit to the defect being treated. [Business Wire] Press Release

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NEW Scientist – Mesenchymal Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

NEW Scientist – Myogenic Progenitor Cell Biology (STEMCELL Technologies Inc.)

NEW Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

NEW Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Postdoctoral Position – Bioengineering (The Andalusian Centre for Nanomedicine and Biotechnology)

Postdoctoral Position – Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Position – Cellular Therapy and Regenerative Medicine of Ocular Pathology (IDIBAPS – August Pi i Sunyer Biomedical Research Institute)

Instructor – Regulation of Stem Cell Differentiation in Vascular Disease (University of Alabama at Birmingham)

Postdoctoral Research Scholar – The Role of Mesenchymal Factors in Cancer Progression (Washington University School of Medicine)

Postdoctoral Position – Epigenetics and Stem Cell Biology (Max Planck Institute for Heart and Lung Research)

PhD Position – The Role of Chromatin in Alternative Splicing Regulation during Cell Fate Decision (Institute of Molecular Biology)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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