Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase The authors present the first evidence that microRNA (miR)-195 overexpressed in old mesenchymal stem cells induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase, and abrogation of miR-195 can reverse stem cell aging. [Stem Cells] Abstract Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice Scientists determined whether xenogeneic administration of conditioned media or extracellular vesicles from human bone marrow-derived mesenchymal stromal cells would be effective in a model of mixed Th2/Th17, neutrophilic-mediated allergic airway inflammation, reflective of severe refractory asthma, induced by repeated mucosal exposure to Aspergillus hyphal extract in immunocompetent C57Bl/6 mice. [Stem Cells Transl Med] Abstract Bone Marrow-Derived Mesenchymal Stem Cells Ameliorate Chronic High Glucose-Induced β-Cell Injury through Modulation of Autophagy Researchers investigated whether bone marrow-derived mesenchymal stem cells could ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy. [Cell Death Dis] Full Article Olfactory Ecto-Mesenchymal Stem Cells Possess Immunoregulatory Function and Suppress Autoimmune Arthritis Investigators found that mouse olfactory ecto-mesenchymal stem cells (MSCs) expressed higher transforming growth factor-beta and interleukin-10 levels than bone marrow-derived MSCs. [Cell Mol Immunol] Abstract Correlation between In Vitro Expansion-Related Cell Stiffening and Differentiation Potential of Human Mesenchymal Stem Cells Human mesenchymal stem cells were cultured and routinely passaged on tissue-culture polystyrene to investigate the correlation between cell stiffening and differentiation potency during in vitro aging. [Differentiation] Abstract Preparation and Characterization of Directed, One-Day-Self-Assembled Millimeter-Size Spheroids of Adipose-Derived Mesenchymal Stem Cells Scientists prepared millimeter-order spheroids of adipose-derived mesenchymal stem cells (ADSCs) by controlling the spheroid size. Notably, spheroid generation required only one-day of culture on charged culture dishes. Almost all spheroid-derived ADSCs were viable and produced adhesion molecules and growth factors, which play an important role in tissue regeneration. [J Biomed Mater Res A] Abstract Basic Fibroblast Growth Factor Stimulates the Proliferation of Bone Marrow Mesenchymal Stem Cells in Giant Panda (Ailuropoda melanoleuca) Researchers investigated the role of basic fibroblast growth factor (bFGF) on the proliferation of bone marrow-mesenchymal stem cells (MSCs) derived from giant panda. MSCs were cultured for cell proliferation analysis at 24, 48 and 72 hours following the addition of bFGF. [PLoS One] Full Article Treatment of Perianal Fistulas with Human Embryonic Stem Cell-Derived MSCs: A Canine Model of Human Fistulizing Crohn’s Disease Investigators evaluated the safety and efficacy of intralesional injection of human embryonic stem cell-derived mesenchymal stem/stromal cells (MSCs) in canine anal furunculosis dogs. [Regen Med] Full Article | Press Release Single CD271 Marker Isolates Mesenchymal Stem Cells from Human Dental Pulp Investigators used different combinations of surface markers to isolate homogeneous populations of dental mesenchymal stem cells from heterogeneous dental pulp cells obtained from dental pulp tissue and compared their capacity to undergo multilineage differentiation. [Int J Oral Sci] Full Article |