Mesenchymal Cell News 10.20 May 22, 2018 | |
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TOP STORYHypoxia Induces Senescence of Bone Marrow Mesenchymal Stem Cells via Altered Gut Microbiota Investigators observed premature senescence of bone marrow MSCs and abnormal D-galactose accumulation in patients with cyanotic congenital heart disease. The hypoxia that these patients experienced resulted in an altered diversity of gut microbial communities, with a remarkable decrease in the number of Lactobacilli and a noticeable reduction in the amount of enzyme-degraded D-galactose. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROSmall Hypoxia-Primed Mesenchymal Stem Cells Attenuate Graft-versus-Host Disease Scientists showed that small MSCs primed with hypoxia and calcium ions exhibited enhanced stemness and immunomodulatory functions for treating allogeneic conflicts. [Leukemia] Abstract Retinoid X receptor alpha (RXRα) was significantly upregulated following the differentiation of human MSCs toward the formation of endothelial cells. [Cell Death Dis] Full Article Researchers investigated the presence of MSCs in the development of tertiary lymphoid structures in murine lupus nephritis (LN), as well as the role of human MSCs as lymphoid tissue organizer cells on the activation of CD4+ T cells from three groups of donors including healthy, SLE and LN patients. [Sci Rep] Full Article The authors cultured human bone marrow and kidney perivascular stromal cells in the TopoWell plate, a custom-fabricated multi-well plate containing 76 unique bioactive surface topographies. Using fluorescent imaging, they observed profound changes in cell shape, accompanied by major quantitative changes in the secretory capacity of the MSCs. [Sci Rep] Full Article IN VIVONox2 inhibitor and Nox2 siRNA were used to block Nox2 in bone marrow MSCs (BMSCs), and the cell viability, apoptosis, senescence and survival of BMSCs were determined by CCK-8, Edu staining, TUNEL staining, β-galactosidase assay and DAPI labeling. [J Cell Physiol] Abstract Scientists studied the effect of MSC administration on the hematopoietic stem cell (HSC) compartment in the bone marrow (BM) in mice. Following injection of MSC, HSC numbers in the BM decreased coinciding with an increased cell cycle activity compared to PBS-injected controls. [Exp Hematol] Abstract Extracellular Matrix Protein DMP1 Suppresses Osteogenic Differentiation of Mesenchymal Stem Cells Dentin matrix protein 1 (DMP1) conditional knockout mice model under Prx1cre was generated to explore whether DMP1 regulates MSCs osteogenic differentiation. Specific ablation of DMP1 in Prx1 positive MSCs increased bone mass in vivo and promoted osteoblasts activity in vitro. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSMesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges Administration of MSCs to diseased hearts improves cardiac function and reduces scar. These effects occur via stimulation of endogenous repair mechanisms, including regulation of immune responses, tissue perfusion, inhibition of fibrosis and proliferation of resident cardiac cells. [Mol Ther] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSThe University of Kansas Medical Center announced that the FDA has cleared it to begin a first-in-human clinical trial of MSCTC-0010 in patients with de novo high-risk acute or steroid-refractory acute graft-versus-host disease. [The University of Kansas Medical Center (Newswise, Inc.)] Press Release Longeveron Receives TEDCO Grant to Fund Stem Cell Research Longeveron LLC announced that it has received a $750,000 grant from the Maryland Technology Development Corporation (TEDCO). Longeveron will apply the funding towards its clinical trial examining the safety and efficacy of its allogeneic MSC product to improve flu vaccine immune-response in elderly patients with frailty. [Longeveron LLC (PR Newswire Association, LLC.)] Press Release | |
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POLICY NEWSScience Needs Clarity on Europe’s Data-Protection Law As a commendable European law on personal data comes into force, the research community must not let excessive caution about data sharing, however understandable, become the default position. [Nature News] Editorial Indonesian Plan to Clamp Down on Foreign Scientists Draws Protest The government’s proposals include stricter rules, and tougher penalties for researchers who break existing ones. [Nature News] Editorial Defeated but Unbowed: Two Pennsylvania Scientists Regroup after Primary Loss Two young scientists are picking up the pieces after Pennsylvania voters shattered their dreams of winning a seat in the U.S. House of Representatives. But neither is planning to walk away from politics. [ScienceInsider] Editorial Congress Tees Up a Vote that Could Send ‘Right-to-Try’ Measure to Trump’s Desk Patients with life-threatening conditions could soon have a new way to ask drug makers for medicines the FDA hasn’t yet approved, if the House is able to clear a version of “right-to-try” legislation. [STAT News] Editorial
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EVENTSNEW International Society for Cellular Therapy (ISCT) EU 2018 Regional Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Researcher – Osteoarthritis and MSCs (NUI Galway) Postdoctoral Position – Stem Cells, Regenerative Biology (Helmholtz Zentrum München) Postdoctoral Fellow – Cell Biology and Disease (European Molecular Biology Laboratory) Senior Lecturer – Cell Biology and Genetics (University of Chicago) Postdoctoral Position – Cell Biology (University of Houston) Review Scientists – Gene and Cell Therapy (Center for Biologics Evaluation and Research) Scientist – Stem Cell and Regenerative Biology (Moderna Therapeutics) Assistant Professor – Regenerative Medicine (University of California, San Diego) Postdoctoral Research Fellow – Musculoskeletal Tissue Regeneration (University of South Dakota) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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