| PUBLICATIONS (Ranked by impact factor of the journal) | LABORATORY RESEARCH Ligand-Independent Activation of Ephrin Receptor A2 by Arachidonic Acid Induces Metastasis-Like Behavior in Prostate Cancer Cells Researchers investigated the signaling mechanism by which the omega-6 polyunsaturated fatty acid arachidonic acid induces prostatic cellular migration to bone marrow stroma. [Br J Cancer] Abstract Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of MicroRNA (miR)-200c and miR-205 To uncover key mechanisms of docetaxel insensitivity in prostate cancer, the authors established docetaxel-resistant sublines. They report that docetaxel-resistant cells underwent an epithelial-to-mesenchymal transition during the selection process, leading to diminished E-cadherin levels and up-regulation of mesenchymal markers. [Am J Pathol] Full Article Nuclear Signal of Androgen Receptor (NESAR) Regulation of Androgen Receptor Level in Human Prostate Cell Lines via Ubiquitination and Proteasome-Dependent Degradation Using fluorescence microscopy, Western blot, and pulse chase assay, researchers showed that nuclear export signal (NES)AR can significantly enhance the degradation of fusion protein constructs in PC3 prostate cancer cells. [Endocrinology] Abstract 4-O-Methylhonokiol, a Peroxisome Proliferator Activated Receptor Gamma Agonist, Inhibits Prostate Tumor Growth: p21 Mediated Suppression of NF-KB Activity Scientists investigated the effects of 4-O-methylhonokiol, a constituent of Magnolia officinalis, on human prostate cancer cell growth and its mechanism of action. [Br J Pharmacol] Abstract Activation of AMP-Activated Protein Kinase by 3,3′-Diindolylmethane (DIM) Is Associated with Human Prostate Cancer Cell Death In Vitro and In Vivo The authors uncovered whether AMP-activated protein kinase (AMPK) is a molecular target of BR-DIM (B-DIM) in human prostate cancer cells. Results showed that B-DIM could activate the AMPK signaling pathway, associated with suppression of the mammalian target of rapamycin, down-regulation of androgen receptor expression, and induction of apoptosis in both androgen-sensitive and androgen-insensitive prostate cancer cells. [PLoS One] Full Article Nuclear Factor-Kappa B and Interleukin-6 Related Docetaxel Resistance in Castration-Resistant Prostate Cancer Scientists investigated the dynamics of the relationship between nuclear factor-kappa B and interleukin-6 in the shift from docetaxel-naive castration-resistant prostate cancer to docetaxel-resistance in patients and cell lines. [Prostate] Abstract Molecular Phenotyping of Circulating Tumour Cells in Patients with Prostate Cancer: Prediction of Distant Metastases Investigators aimed to find the molecular phenotype in circulating cancer cells from patients with prostate cancer in order to predict distant metastases. They also aimed to determine genes affecting the study endpoints of overall survival and time to progression. [BJU Int] Abstract Prolonged Androgen Deprivation Leads to Downregulation of Androgen Receptor and Prostate-Specific Membrane Antigen in Prostate Cancer Cells The authors described an in vitro model for assessing the effects of continuous androgen-deprivation on prostate cancer cells with respect to the expression of two prostate-specific markers: the androgen receptor and prostate-specific membrane antigen. [Int J Oncol] Abstract CLINICAL RESEARCH Positive Predictive Value of Prostate Biopsy Indicated by Prostate-Specific-Antigen-Based Prostate Cancer Screening: Trends Over Time in a European Randomized Trial Scientists assessed the positive predictive value of prostate biopsy, indicated by a prostate-specific antigen threshold of ≥3.0 ng/mL, over time, in the Rotterdam section of the European Randomized study of Screening for Prostate Cancer. [BJU Int] Abstract
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