LABORATORY RESEARCH Lysophosphatidic Acid (LPA) Receptor Heterodimerizes with CD97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells Researchers address the signaling properties and the functional significance of CD97 expression in prostate cancer. [Cancer Res] Abstract Male Germ Cell-Associated Kinase (MAK) Is Overexpressed in Prostate Cancer Cells and Causes Mitotic Defects via Deregulation of APC/CCDH1 In this study, researchers determined the activating mechanism of MAK and identified a previously unknown androgen receptor-independent role of MAK in mitosis. [Oncogene] Abstract Identification of CAD as an Androgen Receptor Interactant and an Early Marker of Prostate Tumor Recurrence Researchers demonstrate an unsuspected function for a key metabolic enzyme and identify carbamoyl-phosphate synthetase II, aspartate transcarbamylase, and dihydroorotase (CAD) as a potential predictive marker of cancer relapse. [FASEB J] Abstract Expression of the IGF Axis Is Decreased in Local Prostate Cancer but Enhanced after Benign Prostate Epithelial Differentiation and TGF-ß Treatment Researchers reveal a functional role of the insulin-like growth factor (IGF) axis in prostate differentiation, underscoring the importance of the IGF axis in normal development and emphasizing the importance of accurate target validation before moving to advanced clinical trials. [Am J Pathol] Abstract Hormonal Therapy Promotes Hormone-Resistant Phenotype by Increasing DNA Methyltransferase Activity and Expression in Prostate Cancer Models Researchers hypothesized that hormonal therapy favors the development of the hormone-resistant phenotype through epigenetic mechanisms. [Endocrinology] Abstract MicroRNAs (miRNAs) Associated with Metastatic Prostate Cancer The objective of this study was to identify down- and up-regulated miRNAs in prostate cancer that could provide potential biomarkers and/or therapeutic targets for prostate cancer metastasis. [PLoS One] Abstract Clusterin (CLU) Is a Critical Downstream Mediator of Stress-Induced YB-1 Transactivation in Prostate Cancer Researchers indicate that Y-box binding protein-1 (YB-1) transactivation of CLU in response to stress is a critical mediator of paclitaxel resistance in prostate cancer. [Mol Cancer Res] Abstract Liposomal Doxorubicin Improves Radiotherapy (RT) Response in Hypoxic Prostate Cancer Xenografts In this study, researchers investigated the combination of RT with the cytotoxic agent doxorubicin encapsulated in pegylated liposomes. [Radiat Oncol] Abstract CLINICAL RESEARCH BRCA2 Is a Moderate Penetrance Gene Contributing to Young-Onset Prostate Cancer: Implications for Genetic Testing in Prostate Cancer Patients Researchers suggest that routine testing of early onset prostate cancer cases for germline BRCA2 mutations will further help to refine the prevalence and risk associated with BRCA2 mutations and may be useful for guiding management options. [Br J Cancer] Abstract A Prostate Cancer Chemoprevention Study: An Investigative Randomized Control Study Using Purified Isoflavones in Men with Rising PSA To examine the prostate cancer risk based on isoflavone intake and equol production, researchers conducted a phase II, randomized, double-blind, placebo-controlled trial of oral isoflavone (60 mg/day) for 12 months. [Cancer Sci] Abstract Serum Levels of Selenium and Smoking Habits at Age 50 Influence Long Term Prostate Cancer Risk; A 34 Year Uppsala Longitudinal Study of Adult Men Follow-Up Researchers investigated the relation between serum selenium level (s-Se), smoking and non-screening detected prostate cancer and explored if polymorphisms in two DNA repair genes: OGG1 and MnSOD, influenced any effect of s-Se. [BMC Cancer] Abstract Impact of Pretreatment Factors, Biopsy Gleason Grade Volume Indices and Post-Treatment Nadir PSA on Overall Survival in Patients with Metastatic Prostate Cancer Treated with Step-Up Hormonal Therapy Various pretreatment clinical findings including serum PSA, testosterone, alkaline phosphatase, digital rectal examination and extension of disease score were investigated for predicting outcomes in step-up hormonal treatment. [Prostate Cancer Prostatic Dis] Abstract |