Pancreatic Cell News 8.46 November 21, 2017 | |
| |
TOP STORYStress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas Investigators showed that accumulation of the autophagy substrate p62/SQSTM1 in stressed KrasG12D acinar cells is associated with pancreatic ductal adenocarcinoma development and maintenance of malignancy in human cells and mice. [Cancer Cell] Abstract | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISThe authors developed an anti-human selenoprotein P (SeP) monoclonal antibody AE2 with neutralizing activity against SeP. Administration of AE2 to mice significantly improved glucose intolerance and insulin resistance that was induced by human SeP administration. [Nat Commun] Full Article Resveratrol Ameliorates the Severity of Fibrogenesis in Mice with Experimental Chronic Pancreatitis Scientists demonstrated that the oral administration of resveratrol effectively attenuated pancreatic stellate cell activation, extracellular matrix deposition, fibrogenesis and acinar atrophy in the pancreatitic parenchyma of cerulein-induced mice as the damage index score was improved by 45.5%. [Mol Nutr Food Res] Abstract Researchers confirmed mitochondrial (mt) DNA copy number decrease down to <30% in pancreatic islets of one-year-old Goto Kakizaki rats. Studying relations to mt nucleoids sizes, they employed 3D superresolution fluorescent photoactivable localization microscopy with lentivirally transduced Eos conjugate of mt single-stranded-DNA-binding protein or transcription factor TFAM; or by 3D immunocytochemistry. [Sci Rep] Full Article Scientists showed that sirolimus impairs glucose-stimulated insulin secretion both in human and murine pancreatic islets and in clonal β cells in a dose- and time-dependent manner. [Sci Rep] Full Article PANCREATIC CANCERMicroRNA Expression Profiling of Pancreatic Cancer Cell Line L3.6p1 following B7-H4 Knockdown A microarray technique was used to screen B7-H4-related differentially expressed miRNAs in a pancreatic cancer cell line associated with pancreatic cancer. [Cell Physiol Biochem] Full Article Scientists found that YTH domain family 2 (YTHDF2) expression is up-regulated in pancreatic cancer tissues compared with normal tissues at both mRNA and protein levels, and is higher in clinical patients with later stages of pancreatic cancer, indicating that YTHDF2 possesses potential clinical significance for diagnosis and prognosis of pancreatic cancers. [Cell Cycle] Abstract Investigators produced plasma-activated lactated Ringer’s solution (PAL) and evaluated its antitumor effect and mechanism. They evaluated the effect of the intraperitoneal administration of PAL using a peritoneal dissemination mouse tumor model. [Ann Surg Oncol] Abstract In vitro analysis of chemotherapy resistance and L-type amino acid transporter 1 (LAT1) function using pancreatic ductal adenocarcinoma cell lines was performed. [Cancer Chemother Pharmacol] Abstract | |
| |
REVIEWSAn Overview of Polyamine Metabolism in Pancreatic Ductal Adenocarcinoma Scientists describe what is currently known about polyamine metabolism in pancreatic ductal adenocarcinoma and identify new targets and opportunities to treat this disease. [Int J Cancer] Abstract Experimental Models of Pancreatic Cancer Desmoplasia The authors review various in vitro and in vivo models that are being used or have the potential to be used to study desmoplasia in pancreatic cancer. [Lab Invest] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
| |
INDUSTRY NEWSCELLINK Enters a Collaborative Research Program with Takara Bio CELLINK and Takara Bio Europe AB will collaborate to evaluate bioprinting of CELLINK’s Bioink with Takara’s cells for insulin secretion by induced pluripotent stem cell derived beta cells. [CELLINK AB] Press Release Sabga Foundation Pledges $1 Million towards TGen Pancreatic Cancer Research World Pancreatic Cancer Day is the kickoff of a $1 million drive by the recently formed John E. Sabga Foundation to fund an innovative clinical trial led by the Translational Genomics Research Institute (TGen) to test revolutionary new treatments for pancreatic cancer. [Translational Genomics Research Institute] Press Release | |
| |
POLICY NEWSDirector of HHS Scientific Fraud Office Is out after Stormy 2-Year Tenure The controversial director of the office that polices research fraud in U.S.-funded biomedical labs is temporarily moving to another agency. Kathy Partin has been removed after nearly two years as director of the U.S. Office of Research Integrity in Rockville, Maryland, according to Retraction Watch. [ScienceInsider] Editorial European Medicines Agency Will Move to Amsterdam The European Medicines Agency, charged with evaluating human and animal medicinal products for the European Union, will relocate to Amsterdam after it was selected in a draw of lots between it and Milan. [ScienceInsider] Editorial Hungary Rewards Highly Cited Scientists with Bonus Grants Some top researchers prosper in Hungary as country tries to improve its international standing in science. [Nature News] Editorial Sudden Shift at a Public Health Journal Leaves Scientists Feeling Censored For much of its 22-year existence, few outside the corner of science devoted to toxic chemicals paid much attention to the International Journal of Occupational and Environmental Health. But now, a feud has erupted over the small academic publication, as its editorial board — the scientists who advise the journal’s direction and handle article submissions — has accused the journal’s new owner of suppressing a paper and promoting “corporate interests over independent science in the public interest.” [Pro Publica Inc.] Editorial
| |
EVENTSNEW SYStem – Symposium for the Next Generation of Stem Cell Researchers Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Technologist – Pancreatic Cell Biology (STEMCELL Technologies Inc.) NEW Postdoctoral Positions – Pancreatic Cancer (MD Anderson Cancer Center) Postdoctoral Position – Pathogenesis of Type 1 Diabetes (Helmholtz Zentrum München) Postdoctoral Position – Pancreatic Cancer (Translational Genomics Research Institute) Assistant Professor – Cancer Biology (Perelman School of Medicine) PhD Studentships – Cancer Research (University of Cambridge) Research Fellow – Pancreatic Cancer (Memorial Sloan Kettering Cancer Center) Postdoctoral Position – Pancreatic Cancer (University of California, San Francisco) Faculty Positions – Cancer Research (Huntsman Cancer Institute) Researcher – Cancer Biology (University of Cincinnati) Scientist – Diabetes and Obesity (Helmholtz Zentrum München) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Pancreatic Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|