Leptin Enhances ICAM-1 Expression, Induces Migration and Cytokine Synthesis, and Prolongs Survival of Human Airway Epithelial Cells The authors investigated the effects of leptin on human airway epithelial cells by using human primary airway epithelial cells and a human airway epithelial cell line, BEAS-2B. [Am J Physiol Lung Cell Mol Physiol] Abstract Lipoxin A4 Activates Alveolar Epithelial Sodium Channel Gamma via the MicroRNA-21/PTEN/AKT Pathway in Lipopolysaccharide-Induced Inflammatory Lung Injury Researchers investigated the mechanisms of lipoxin A4 (LXA4) in modulation of epithelial sodium channel gamma in lipopolysaccharide (LPS)-induced inflammatory lung injury. miR-21 was upregulated during an LPS challenge and downregulated by LXA4 administration in vivo and in vitro. [Lab Invest] Abstract Oxidative Stress and Endocytosis Are Involved in Upregulation of Interleukin-8 Expression in Airway Cells Exposed to PM2.5 The mechanisms underlying PM2.5-induced IL-8 gene expression have not been fully characterized. BEAS-2B cells and THP-1 cells were used as the in vitro models to investigate the underlying mechanism in this study. [Environ Toxicol] Abstract Nuclear Translocation of Nuclear Factor Kappa B Is Regulated by G Protein Signaling Pathway in Arsenite-Induced Apoptosis in HBE Cell Line Using human bronchial epithelial cells as a culture system, scientists demonstrated that arsenite-induced nuclear translocation of nuclear factor kappa B resulted in the release of cytochrome c, the modulation of Fas and FasL, caspase activation, and ultimately leading to cell apoptosis. [Environ Toxicol] Abstract Expression and DNA Methylation Status of the Rap2B Gene in Human Bronchial Epithelial Cells Treated by Cigarette Smoke Condensate The authors investigated the Rap2B gene expression and its promoter methylation in human bronchial epithelial cells treated by cigarette smoke condensate. [Inhal Toxicol] Abstract LUNG CANCER LRRC3B Is Downregulated in Non-Small-Cell Lung Cancer and Inhibits Cancer Cell Proliferation and Invasion Researchers checked LRRC3B levels in several lung cancer cell lines and found that its expression was downregulated in four of nine lung cancer cell lines compared with normal human bronchial epithelial cell line. They further explored the biological role of LRRC3B. [Tumour Biol] Abstract Epigenetic Downregulated ITGBL1 Promotes Non-Small Cell Lung Cancer Cell Invasion through Wnt/PCP Signaling Researchers found that knockdown of integrin, beta-like 1 (ITGBL1) in non-small cell lung cancer cell lines could promote cancer cell migration and invasion. Furthermore, recombinant ITGBL1 protein-treated cancer cell could inhibit cell migration and invasion. [Tumour Biol] Abstract Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-Met Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer Model non-small cell lung cancer cell lines H1975 and H2170 were used to study the similarities and differences in mechanisms of EGFR/c-Met tyrosine kinase inhibitor (TKI) resistance. H1975 cells were positive for the T790M EGFR mutation, which confers resistance to current EGFR TKI therapies, while H2170 cells were EGFR wild-type. [PLoS One] Full Article KDM6B Elicits Cell Apoptosis by Promoting Nuclear Translocation of FOXO1 in Non-Small Cell Lung Cancer The authors found that overexpression of KDM6B, a demethylase that acts on histone H3 at lysine 27, inhibited cell growth by initiating mitochondria-dependent apoptosis and by attenuating the invasion-metastasis cascade in non-small cell lung carcinoma cells. [Cell Physiol Biochem] Abstract | Full Article Association between Downexpression of MiR-203 and Poor Prognosis in Non-Small Cell Lung Cancer Patients Investigators identified the relationship between miR-203 expression and clinicopathological significance in non-small cell lung cancer patients in the current study. [Clin Transl Oncol] Abstract |