Pulmonary Cell News 7.13 April 5, 2018 | |
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TOP STORYCirculating and Tumor Myeloid-Derived Suppressor Cells in Resectable Non-Small-Cell Lung Cancer Scientists investigated myeloid-derived suppressor cells (MDSC) and inflammatory factors in tumor and peripheral blood samples from patients with resectable non-small cell lung cancer and studied their correlations with the disease prognosis. A significant increase in the frequency of circulating monocytic-MDSCs was observed in the non-small cell lung cancer patients compared with the healthy donors. [Am J Respir Crit Care Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The interactions of gaseous 2-chlorophenol with Fe3+-saturated montmorillonite particles in a gas-solid system was investigated to simulate the reactions of mineral dusts with volatile organic pollutants in atmosphere. The toxicity of Fe3+-montmorillonite particles to A549 human lung epithelial cells before and after interaction with 2-chlorophenol was examined to explore their adverse impact on human health. [Environ Sci Technol] Abstract Scientists analyzed the function and regulatory mechanism of microRNA-708-3p (miR-708-3p) and evaluated this marker’s potential as a therapeutic target in idiopathic pulmonary fibrosis (IPF). The clinical and biological relevance of fibrogenesis for miR-708-3p was assessed in vivo and in vitro, specifically in matching plasma and tissue samples from 78 patients with IPF. [Exp Mol Med] Full Article The authors investigated the effects of electronic cigarettes (e-cigs) on the inflammatory response and viability of COPD bronchial epithelial cells (BECs). E-cig vapor extract and cigarette smoke extract caused an increase in the release of interleukin-6 and C-X-C motif ligand 8 from Calu-3 cells. [Int J Chron Obstruct Pulmon Dis] Full Article Since airway inflammation is a key factor in chronic obstructive pulmonary disease (COPD) progress, it is crucial to unravel its underlying molecular mechanisms. The analyses of IL1B expression level, the Pearson correlation between IL1B and several COPD biomarkers were performed using other cohorts to validate our main findings. [Inflamm Res] Abstract Sulforaphane Attenuates Pulmonary Fibrosis by Inhibiting the Epithelial-Mesenchymal Transition To assess the effect of sulforaphane (SFN) on the epithelial-mesenchymal transition and fibrosis using an in vitro transforming growth factor-β1-induced model and an in vivo bleomycin (BLM)-induced model. SFN reversed mesenchymal-like changes induced by TGF-β1 and restored cells to their epithelial-like morphology. [BMC Pharmacol Toxicol] Full Article LUNG CANCERResearchers found that pharmacological inhibition of AKT, through the highly selective AKT inhibitor VIII, impairs RBL2/p130 Ser941 phosphorylation and increases RBL2/p130 stability, mRNA expression and nuclear levels in both lung cancer and mesothelioma cell lines, mirroring the more extensively studied effects on the p27 cell-cycle inhibitor. [Oncogene] Abstract Investigators developed a 3D co-culture model of lung adenocarcinoma cells and macrophages in an interpenetrating network hydrogel, to investigate the influence of the macrophage phenotype and ECM stiffness in the induction of epithelial-to-mesenchymal transition. [Biofabrication] Abstract Curcumin Enhances the Anti-Cancer Effects of Paris Saponin II in Lung Cancer Cells Researchers investigated the synergistic mechanisms of paris saponin II (PSII) and curcumin (CUR) in lung cancer. The combination changed the cellular uptake of CUR and PSII, apoptosis, cell cycle arrest and cytokine levels were analyzed on different lung cancer cells. [Cell Prolif] Abstract To develop a more effective anticancer drug for solid cancers, Dex was modified by ionizing radiation and the anticancer activity of ionizing-radiation-irradiated Dex (Dex-IR) was investigated in human lung cancer cells. Using the MTT assay, the proliferation of non-small cell lung cancer cells was significantly inhibited after treatment with Dex-IR compared with Dex. [PLoS One] Full Article | |
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REVIEWSRegulation of Alveolar Macrophage Death in Acute Lung Inflammation The authors focus on recent advances in the regulation and underlying mechanisms of alveolar macrophage (AM) death as well as the influence of AM death on the development of acute lung injury. [Respir Res] Full Article Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSSTEMCELL Technologies Partners with the ATS to Offer Travel Scholarships STEMCELL Technologies has entered into a partnership with the American Thoracic Society (ATS) to offer the STEMCELL Technologies Scholarships to attend the ATS 2018 International Conference in San Diego, California. [STEMCELL Technologies Inc.] Press Release Sunovion Pharmaceuticals Inc. announced that Lonhala™ Magnair™ Inhalation Solution is now available at pharmacies in the U.S. for the long-term, maintenance treatment of airflow obstruction in people with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. [Sunovion Pharmaceuticals Inc.] Press Release Pfizer Inc. announced that the FDA accepted the company’s New Drug Application and granted priority review for dacomitinib, a pan-human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, for the first-line treatment of patients with locally advanced or metastatic non-small cell lung cancer with EGFR-activating mutations [Pfizer Inc.] Press Release Aeglea BioTherapeutics, Inc. announced treatment of the first patients with pegzilarginase in two small cell lung cancer trials, the single-agent Phase I cohort expansion and the Phase I/II combination trial with KEYTRUDA®, an anti-PD-1 therapy marketed by Merck. [Aeglea BioTherapeutics, Inc.] Press Release | |
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POLICY NEWSUnnecessary Exclusions Shut Patients out of Clinical Trials The FDA will hold a public meeting in Washington to discuss issues related to clinical trial eligibility criteria. Researchers, study sponsors, patients, and the general public will have an opportunity to share their experiences and tell our regulators why it’s time to revisit the guidelines. [STAT News] Editorial Cancer Researchers Push to Relax Rules for Clinical Trials US government examines whether criteria for participating in drug studies unnecessarily exclude some people. [Nature News] Editorial Cancer Researcher at the Ohio State University Resigns following Multiple Misconduct Findings A cancer researcher has resigned from The Ohio State University in Columbus after the institution determined he had committed misconduct in eight papers. His work in designing anticancer compounds had led to millions of dollars in funding and multiple patents, as well as two compounds in clinical trials. [ScienceInsider] Editorial EU Copyright Reforms Draw Fire from Scientists An influential committee of the European Parliament is due to vote on changes to copyright regulations in the European Union (EU), but the latest drafts of the rules have triggered a wave of criticism from open-science advocates. They say that the proposals will stifle research and scholarly communication. [Nature News] Editorial
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EVENTSNEW 6th Cambridge International Stem Cell Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholar – Lung Cancer (University of California, San Francisco) Research Technologist – Pulmonary (STEMCELL Technologies Inc.) Postdoctoral Position – Cell and Molecular Biology (Helmholtz Zentrum München) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Senior Research Scientist – Lung Epithelium (AstraZeneca) Research Scientist – Cell Biologist (MedImmune) Full Professorship and Director – Lung Biology (Ludwig-Maximilians-Universität München) Postdoctoral Traveling Fellowship – Lung Cancer (Cancer Research UK) Postdoctoral Position – Immune Oncology (H. Lee Moffitt Cancer & Research Institute) Assistant Professor – Pulmonary Physiology (University of California, Riverside) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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