Pulmonary Cell News 7.29 July 26, 2018 | |
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TOP STORYTumor Innate Immunity Primed by Specific Interferon-Stimulated Endogenous Retroviruses Stimulated 3 prime antisense retroviral coding sequences (SPARCS) were oriented inversely in 3′ untranslated regions of specific genes enriched for regulation by STAT1 and EZH2. Analysis of cell lines with high inducible SPARCS expression revealed strong association with an AXL/MET-positive mesenchymal cell state. [Nat Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Increased Extracellular Vesicles Mediate WNT-5A Signaling in Idiopathic Pulmonary Fibrosis The primary human lung fibroblast (phLF)-derived extracellular vesicles (EVs) induced phLF proliferation, which was attenuated by WNT-5A silencing and antibody-mediated inhibition and required intact EV structure. Similarly, EVs from idiopathic pulmonary fibrosis-bronchoalveolar lavage fluid induced phLF proliferation, which was mediated by WNT-5A. [Am J Respir Crit Care Med] Abstract The authors investigated persistent effects of galactic cosmic radiation exposure on DNA repair capacity in lung-derived epithelial cells, using an enzyme-stimulated chromosomal rearrangement as an endpoint. [Sci Rep] Full Article Primary human alveolar epithelial cells type II were extracted from donor tissues and stimulated with transforming growth factor beta (TGFβ) and a TGFβ-inhibitor. Interaction modules exhibited enrichment of genes that favored actin cytoskeleton remodeling, differentiation processes and collagen metabolism. [Respir Res] Full Article LUNG CANCERThe transforming growth factor-β (TGFβ) superfamily ligands activin A and growth differentiation factor 11 (GDF11) mediated resistance via their cognate receptors through TGFβ-activated kinase 1, rather than through the SMAD family of transcription factors. Inhibition of activin receptor signaling or blockade of activin A and GDF11 by the endogenous protein follistatin overcame this resistance. [Sci Transl Med] Abstract | Press Release Macrophages promoted ubiquitin-specific peptidase 17 (USP17) expression in cancer cells. Overexpression of USP17 in cancer cells promoted tumor growth and inflammation-associated and stemness-associated gene expressions in tumors. [Oncogene] Full Article Overexpression of TRIM37 antagonized cisplatin‐induced apoptosis, induced angiogenesis and proliferation, and increased the aggressiveness of non-small-cell lung cancer cells in vitro and in vivo, whereas inhibition of TRIM37 led to the opposite effects. [J Pathol] Abstract Investigators revealed erlotinib-resistant cells have lower spare respiratory capacity (SRC), an indicator of metabolic flexibility, compared to erlotinib-sensitive cells. Knockdown of an mTORC2 component, rictor, enhanced the SRC and rescued the growth rate of erlotinib-resistant cells during glucose deprivation. [Cancer Lett] Full Article Pseudopodium-enriched atypical kinase 1 (PEAK1) overexpression could induce epithelial-to-mesenchymal transition and the expression of matrix metalloproteinase-2 (MMP2) and MMP9 both in vitro and in vivo, whereas PEAK1 knockout had the opposite effects. [Cell Death Dis] Full Article Knockdown of nuclear-enriched abundant transcript 1 (NEAT1) in lung adenocarcinoma cells markedly restrained cell proliferation, invasion, and migration and stimulated cell apoptosis. Researchers demonstrated that miR-193a-3p directly targeted NEAT1 at its 3’-UTR. [Cell Physiol Biochem] Full Article Subscribe to one of our other 19 science newsletters such as Intestinal Cell News & Human Immunology News. | |
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REVIEWSThe Polycomb Group Proteins Functions in Epithelial to Mesenchymal Transition in Lung Cancer The authors explore the mechanism-based relationship and functional roles of polycomb group proteins in the interplay between epithelial mesenchymal transition and chromatin dynamics in lung cancer. [Semin Cell Dev Biol] Abstract Mitochondrial Quality Control in COPD and IPF Investigators outline the role of mitochondria quality control systems in the pathogenesis of age-associated lung diseases, COPD and idiopathic pulmonary fibrosis (IPF). [Cells] Full Article Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSTakeda Pharmaceutical Company Limited announced that the global, randomized, Phase III ALTA-1L trial met its primary endpoint at the first pre-specified interim analysis, with ALUNBRIG®. [Takeda Pharmaceutical Company Limited (Business Wire, Inc.)] Press Release Pulmatrix, Inc. announced the formation of the Clinical Advisory Board for Pulmazole – an inhaled iSPERSE™ formulation of the anti-fungal drug itraconazole for the treatment of allergic bronchopulmonary aspergillosis in patients with asthma. [Pulmatrix Inc.] Press Release | |
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POLICY NEWSThe UK and Indian governments signaled their commitment to a deeper relationship by jointly announcing four new awards worth £4.8 million under the Civil Nuclear Energy program and seven new awards worth £10.8 million under Phase 2 of the Global research program on health. [GOV.UK] Editorial New Evidence USCIS Policies Increased Denials of H-1B Visas New data show that in 2017, U.S. Citizenship and Immigration Services (USCIS) denied many more H-1B petitions and issued numerous costly Requests for Evidence to stop highly educated foreign nationals from working in America. [Forbes Media LLC] Editorial Third Retraction for Harvard Cancer Biologist Nature has issued a retraction of a cancer study, seven years after its publication, citing issues with two figures and the unavailability of original data for them. The paper, led by Harvard Medical School biologist Sam Lee, is among several publications from his group to be retracted. [The Scientist] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) 2019 Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Fellow – Non-Small Cell Lung Cancer (The University of Texas MD Anderson Cancer Center) Postdoctoral Fellow – Lung and Vascular Diseases (Icahn School of Medicine at Mount Sinai) Postdoctoral Fellow – Cellular Therapeutics in Chronic Lung Disease (Helmholtz Zentrum München) Postdoctoral Associate – Chemotherapy and Radiation Therapy (Baylor College of Medicine) Principal Investigators – Cancer (University of Alabama Birmingham) Postdoctoral Position – Immunology/Molecular Biology (National Heart, Lung and Blood Institute) Postdoctoral Position – Vascular or Lung Biology (Yale University School of Medicine) Postdoctoral Fellow – Human Lung Stem Cells and Regeneration (MedImmune) Postdoctoral Fellow – Virology and Respiratory Biology (MedImmune) Postdoctoral Fellow – Immunology (NYU Langone Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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