Cord Blood News Volume 11.17 | May 9 2019

TOP STORY

Single-Cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

Scientists report the transcriptomes of 17,637 umbilical cord blood cells, covering 12 major cell types, many of which can be further divided into distinct subpopulations. [Gigascience] Full Article

(Ranked by impact factor of the journal)

Single Cell Transcriptomic Analysis of Human Mesenchymal Stem Cells Reveals Limited Heterogeneity

Researchers profiled the transcriptomes of 361 single MSCs derived from two umbilical cords (UC-MSCs). These UC-MSCs were harvested at different passages and stimulated with or without inflammatory cytokines. [Cell Death Dis] Full Article

Unit Selection for Umbilical Cord Blood Transplantation for Adults with Acute Myeloid Leukemia in Complete Remission: A Japanese Experience

To investigate optimal unit selection for umbilical cord blood transplantation (UCBT), scientists conducted a registry-based study of 1355 adults with acute myeloid leukemia in first or second complete remission who underwent single-unit UCBT. [Bone Marrow Transplant] Abstract

Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury – A Brain Transcriptome Profiling Analysis

The authors explored possible mechanisms of action using next generation RNA sequencing to analyze the brain transcriptome profiles in rats with ischemic brain injury following umbilical cord blood stem cell therapy. [Cell Transplant] Full Article

Angiotensin II and TGF-β1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation

Investigators verified angiotensin II and transforming growth factor-beta 1 (TGF-β1) as potential cardiomyogenic differentiation inducers of amniotic fluid-derived-MSCs. [Int J Stem Cells] Abstract

Application of High Throughput Next Generation Sequencing for HLA Typing of DNA Extracted from Post Processing Cord Blood Units

DNA extracted from buffy coat of cord blood samples were typed for HLA‐ A, B, C, DRB1 and DQB1 alleles by Illumina miniseq and the sequences were aligned, phased and mapped by Mia Fora software algorithms. [HLA] Abstract

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Biological Functions of Mesenchymal Stem Cells and Clinical Implications

The authors outline the fundamental and advanced concepts of MSC biological features and underline the biological functions of MSCs in their basic and translational aspects in therapy for degenerative and/or inflammatory diseases. [Cell Mol Life Sci] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

ExCellThera Enters into a Manufacturing and Collaboration Agreement with New York Blood Center

ExCellThera Inc. announced that it has entered into a manufacturing and collaboration agreement with Comprehensive Cell Solutions for the clinical grade production of ExCellThera’s lead cell therapy product, ECT-001. [ExCellThera Inc.] Press Release

Tmunity and UC San Francisco Announce Exclusive License and Research Collaboration to Advance TCR T Cell Therapies for Pediatric Cancers

Tmunity Therapeutics, Inc. announced it has entered into an exclusive licensing and research collaboration with the University of California (UC) San Francisco aimed at advancing novel engineered T cell receptor therapies for rare and currently incurable pediatric conditions with high mortality rates. [Tmunity Therapeutics, Inc.] Press Release

White House to Convene Committee to Address Research Obstacles

The leaders of the White House Office of Science and Technology, National Institutes of Health, National Science Foundation, National Institute of Standards and Technology, and the Department of Energy’s science division have formed a committee “to address issues facing the U.S. research community,” President Donald Trump’s administration announced. [The Scientist] Editorial

Black Academics Publish One-Fifth of South Africa’s Research

The proportion of scientific articles published by academics in South Africa who are black, colored or of Indian origin has risen almost tenfold since the end of apartheid, to about one-third, finds a report on scholarly publishing in the country. [Nature News] Editorial

NEW International Society for Stem Cell Research (ISSCR) 2019 Annual Meeting
June 26-29, 2019
Los Angeles, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Researcher – Normal and Malignant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Stem Cell Transplant Immunology (University of Illinois at Chicago)

Research Technician – Leukemia (VIB)

Postdoctoral Researcher – Stem Cells and Erythropoiesis in MDS (Karolinska Institutet)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern)

Assistant, Associate, or Full-Professor Positions – Cancer Research (Brown University)

Postdoctoral Research Fellow – Functional Genomics (Justus Liebig University Giessen)

Postdoctoral Fellows – Hematological Malignancies and Cancer Immunology (Fox Chase Cancer Center)

Postdoctoral Position – Mechanobiology (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Hematopoietic Stem Cells (Washington University School of Medicine)

Postdoctoral Fellow Positions – Human iPS cells, Epigenetics, Hematopoietic Stem Cell Biology, and Blood Cancers (Nationwide Children’s Hospital & Ohio State University)

Faculty Positions – Cancer Research (Shenzhen University)

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