Cord Blood News Volume 11.23 | Jun 20 2019

TOP STORY

Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis

The authors tested the potential for overexpression of interleukin-10 (IL-10) in human umbilical cord MSCs to increase MSC efficacy in Escherichia coli pneumosepsis and to enhance human macrophage function. [J Clin Med] Abstract | Download Full Article

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Traditional Two-Dimensional Mesenchymal Stem Cells (MSCs) Are Better than Spheroid MSCs on Promoting Retinal Ganglion Cells Survival and Axon Regeneration

Researchers compared the neuroprotection of two forms of human umbilical cord blood-derived MSCs on retinal ganglion cells and axon regeneration after optic nerve crush in vivo, and investigated the molecular mechanism. [Exp Eye Res] Abstract | Graphical Abstract

Preeclampsia and Intrauterine Growth Restriction: Role of Human Umbilical Cord Mesenchymal Stem Cells-Trophoblast Cross-Talk

Investigators quantified the plasma markers of peroxidation in patients affected by preeclampsia (PE) and intrauterine growth restriction (IUGR) and examined the role of oxidative stress in the pathophysiology of PE and IUGR in vitro by using human umbilical cord mesenchymal stem cells from physiological and pathological pregnancies and a trophoblast cell line. [PLoS One] Full Article

In Vitro Toxicity Screening of Magnetite Nanoparticles by Applying Mesenchymal Stem Cells Derived from Human Umbilical Cord Lining

MSCs derived from cord lining membrane were characterized and applied for in vitro toxicity screening of magnetite nanoparticles (Fe₃O₄NP). Cytotoxicity, internalization/uptake, differentiation and proliferative capacity were evaluated after exposure to different Fe₃O₄NP concentrations. [J Appl Toxicol] Abstract

Assessment of Short-Term Engraftment Potential of Ex Vivo Expanded Hematopoietic Stem Cells Using Normal Fetal Mouse In Utero Transplantation Model

Researchers investigated effect of common ex vivo expansion method on engraftment potential of human umbilical cord blood-mononuclear cells, using normal fetal mouse, as a model with more similarity to human physiological conditions. [Cell J] Full Article

Isolation, Expansion, and Characterization of Wharton’s Jelly-Derived Mesenchymal Stromal Cell: Method to Identify Functional Passages for Experiments

Scientists assessed the MSCs characteristic of human Wharton’s jelly mesenchymal stromal cells in in vitro culture according to the criteria established by the International Society for Cellular Therapy. [Methods Mol Biol] Abstract

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Mesenchymal Stem Cells: Cell Therapy and Regeneration Potential

The authors discuss and compare the characteristics of MSCs, and suggest that the variations in their distinctive features are dependent on the source and method of isolation as well as epigenetic changes during maintenance and growth. They also discuss the potential opportunities and challenges of MSC research with the hope to stimulate their use for therapeutic and regenerative medicine. [J Tissue Eng Regen Med] Abstract

Transplantation of Stem Cells from Umbilical Cord Blood as Therapy for Type I Diabetes

Researchers compare the general characteristics of umbilical cord blood-derived (UCB) multipotent stem cells and UCB-MSCs and introduce their applications in type I diabetes mellitus. [Cell Tissue Res] Abstract

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ThermoGenesis Receives Health Canada Approval of Its Next-Generation AXP^® II System for Cord Blood Processing

ThermoGenesis Corp. announced that it has received Health Canada approval of its next-generation AXP^®II system for cord blood processing. [ThermoGenesis Corp.] Press Release

Bone Therapeutics’ Allogeneic Cell Therapy Product, ALLOB, Meets Primary Endpoints in Phase IIa Study in Patients Undergoing a Lumbar Spinal Fusion Procedure

Bone Therapeutics announced that its allogeneic cell therapy product, ALLOB, successfully completed the 12 month follow-up period of a Phase IIa study in patients undergoing a lumbar spinal fusion procedure. [Bone Therapeutics S.A.] Press Release

Trump Issues Executive Order that Could Reduce Scientific Advice

President Donald Trump issued an executive order on June 14 to cut back the number of advisory committees by at least a third by the end of September, according to a statement from the White House. The federal advisory committee system is the formal structure for government agencies to seek advice from experts including scientists. [The Scientist] Editorial

China Clamps Down on Foreign Use of Chinese Genetic Material and Data

China has announced new regulations for the use of human genetic resources that come from Chinese participants. The rules, announced on June 10, require international scientists using biomaterials from China to have a Chinese collaborator and go into effect on July 1. [The Scientist] Editorial

Academics Join Outcry Sparked by Hong Kong’s Contentious Extradition Bill

Since the bill that would legalize the extradition of people from Hong Kong to mainland China to stand trial or serve criminal sentences was announced, more than a thousand academics from around the world have signed a petition against the proposed law, saying it would restrict free speech and academic debate as well as eroding personal freedoms. [Nature News] Editorial

NEW The XVIII International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Meeting
September 20-23, 2019
Edinburgh, United Kingdom

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NEW Postdoctoral Fellow – Hematopoietic Stem Cell Niche in Leukemia (Erasmus Medical Center)

NEW Postdoctoral Researcher – Next Generation Cell Therapy Process Engineering (University of British Columbia)

Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Postdoctoral Position – Leukemia (University of California, San Francisco)

Assistant Director – Cell Therapy Laboratory (MD Anderson Cancer Center)

Research Associate – Oncology and Hematology (University of Manitoba)

Research Fellow – Hematology, Blood Disorders and Stem Cell Biology (New York Blood Center)

Postdoctoral Position – Stem Cell Transplant Immunology (University of Illinois at Chicago)

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