Cord Blood News Volume 11.31 | Aug 15 2019

TOP STORY

In Utero Amniotic Fluid Stem Cell Therapy Protects against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion

The authors investigated the therapeutic effects and mechanisms of human amniotic fluid stem cells (hAFSCs)‐based treatment for fetal myelomeningocele. hAFSCs were isolated as CD117‐positive cells from the amniotic fluid of 15‐ to 17‐week pregnant women who underwent amniocentesis for prenatal diagnosis and consented to this study. [Stem Cells Transl Med] Full Article

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Early Fluid Overload Predicts Higher Non-Relapse and Overall Mortality in Adults after Single-Unit Cord Blood Transplantation

Investigators retrospectively analyzed the data of 227 adult patients who received single-unit cord blood transplantation (CBT) in their institute. The cumulative incidence of grade ≥2 fluid overload was 4% at day 30 after CBT with a median onset at 16 days after CBT. [Bone Marrow Transplant] Abstract

Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hind Limb Ischemia by Promoting Angiogenesis in Mice

In vitro assays indicated that both bone marrow mesenchymal stem cells and umbilical cord MSCs (UCMSCs) promoted human umbilical vein endothelial cell proliferation, migration and tube formation, and the effects of UCMSCs were more obvious. [Stem Cells Dev] Abstract

HucMSCs-Derived miR-206-Knockdown Exosomes Contribute to Neuroprotection in Subarachnoid Hemorrhage Induced Early Brain Injury by Targeting BDNF

Scientists found that treatment with human umbilical cord derived mesenchymal stem cells (hucMSCs)-derived miR-206-knockdown exosomes has a greater neuroprotective effect on subarachnoid hemorrhage-induced early brain injury compared to treatment with simple exosomes. [Neuroscience] Abstract

Liraglutide Combined with Human Umbilical Cord Mesenchymal Stem Cell Transplantation Inhibits Beta‐Cells Apoptosis via Mediating the ASK1/JNK/BAX Pathway in Rats with Type 2 Diabetes Mellitus

Researchers investigated the effects of a combined therapy of liraglutide and human umbilical cord mesenchymal stem cells on the glucose metabolism and islet beta‐cell apoptosis, and further explored its relationship to the ASK1/JNK/BAX pathway. [Diabetes Metab Res Rev] Abstract

Therapeutic Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells Combined with G-CSF on Rats with Acute Liver Failure

Cultured human umbilical cord blood MSCs (hUCB-MSCs) displayed proliferation and adipogenic and osteogenic differentiation potentials. hUCB-MSCs in combination with granulocyte colony-stimulating factor (G-CSF) significantly attenuated acute liver failure-induced liver function injury. [Biochem Biophys Res Commun] Abstract

Intranasally Administered Exosomes from Umbilical Cord Stem Cells Have Preventive Neuroprotective Effects and Contribute to Functional Recovery after Perinatal Brain Injury

Investigators aimed to evaluate the neuroprotective effects of intranasally administered MSC-derived exosomes and their potential to improve neurodevelopmental outcome after perinatal brain injury. [Cells] Abstract | Download Full Article

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Current Status of Umbilical Cord Blood Transplantation in Children

Umbilical cord blood transplantation affords a lower incidence of graft‐versus‐host disease compared to alternative stem cell sources, but also presents a slower immune recovery and a high risk of infections if serotherapy is not omitted or targeted within the conditioning regimen. [Br J Haematol] Abstract

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SA Researchers in National Team to Find and Destroy Dormant Cancer

Professor Andrew Zannettino is about to embark on a three year myeloma study after receiving a $600,000 grant from the Leukaemia Foundation. The Strategic Ecosystem Research Partnership grant will see him work with experts from Sydney’s Garvan Institute and Brisbane’s QIMR Berghofer Medical Research Institute to detect the presence of a group of dormant cancer cells through blood tests. [South Australian Health and Medical Research Institute] Press Release

CHA Biotech Wins Patent for Placenta-Derived Mesenchymal Stem Cells

CHA Biotech said that it has obtained a patent for the use of placenta-derived mesenchymal stem cell lines. By acquiring the patent, the company has secured the right to develop treatments for degenerative neurological diseases using placental-derived mesenchymal stem cells. [Korea Biomedical Review] Press Release

UC Faculty Members Quit Cell Press Editorial Boards over Impasse with Publisher

Some of the University of California’s (UC’s) most prominent scientists have announced they will resign from editorial boards of Cell Press to protest the continuing impasse between its owner, publishing giant Elsevier, and UC over subscription costs and open access to articles. [ScienceInsider] Editorial

Academia to FBI on Monitoring Chinese Scientists: “Tread Carefully”

Nearly two dozen higher education groups warn the government to be cautious when advising US research universities to keep an eye on students and faculty with ties to certain Chinese institutions. [The Scientist] Editorial

NEW Gene Regulation: From Mechanisms to Disease
January 26-30, 2020
Keystone, Colorado, United States

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NEW Postdoctoral Scholarship – Computational Genomics and Bioinformatics (Lund University)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Scholar – Gene and Cell Therapy (Stanford University)

Associate Professor – Pediatrics (Pennsylvania State University)

Early Stage Researchers – Hematopoiesis (Multiple Locations)

Faculty Positions – Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

Postdoctoral Position – Bone/Stem Cell Biology (University of California, San Francisco)

Postdoctoral Research Associate – Development, Regeneration and Cell Fate (Michigan State University)

Tenure-Track Positions – Stem Cell Biology and Regenerative Medicine (Icahn School of Medicine at Mount Sinai)

Postdoctoral Researcher – Next Generation Cell Therapy Process Engineering (University of British Columbia)

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