Cord Blood News 11.31 August 15, 2019 | |
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TOP STORYThe authors investigated the therapeutic effects and mechanisms of human amniotic fluid stem cells (hAFSCs)‐based treatment for fetal myelomeningocele. hAFSCs were isolated as CD117‐positive cells from the amniotic fluid of 15‐ to 17‐week pregnant women who underwent amniocentesis for prenatal diagnosis and consented to this study. [Stem Cells Transl Med] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators retrospectively analyzed the data of 227 adult patients who received single-unit cord blood transplantation (CBT) in their institute. The cumulative incidence of grade ≥2 fluid overload was 4% at day 30 after CBT with a median onset at 16 days after CBT. [Bone Marrow Transplant] Abstract In vitro assays indicated that both bone marrow mesenchymal stem cells and umbilical cord MSCs (UCMSCs) promoted human umbilical vein endothelial cell proliferation, migration and tube formation, and the effects of UCMSCs were more obvious. [Stem Cells Dev] Abstract Scientists found that treatment with human umbilical cord derived mesenchymal stem cells (hucMSCs)-derived miR-206-knockdown exosomes has a greater neuroprotective effect on subarachnoid hemorrhage-induced early brain injury compared to treatment with simple exosomes. [Neuroscience] Abstract Researchers investigated the effects of a combined therapy of liraglutide and human umbilical cord mesenchymal stem cells on the glucose metabolism and islet beta‐cell apoptosis, and further explored its relationship to the ASK1/JNK/BAX pathway. [Diabetes Metab Res Rev] Abstract Cultured human umbilical cord blood MSCs (hUCB-MSCs) displayed proliferation and adipogenic and osteogenic differentiation potentials. hUCB-MSCs in combination with granulocyte colony-stimulating factor (G-CSF) significantly attenuated acute liver failure-induced liver function injury. [Biochem Biophys Res Commun] Abstract Investigators aimed to evaluate the neuroprotective effects of intranasally administered MSC-derived exosomes and their potential to improve neurodevelopmental outcome after perinatal brain injury. [Cells] Abstract | Download Full Article Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
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REVIEWSCurrent Status of Umbilical Cord Blood Transplantation in Children Umbilical cord blood transplantation affords a lower incidence of graft‐versus‐host disease compared to alternative stem cell sources, but also presents a slower immune recovery and a high risk of infections if serotherapy is not omitted or targeted within the conditioning regimen. [Br J Haematol] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSSA Researchers in National Team to Find and Destroy Dormant Cancer Professor Andrew Zannettino is about to embark on a three year myeloma study after receiving a $600,000 grant from the Leukaemia Foundation. The Strategic Ecosystem Research Partnership grant will see him work with experts from Sydney’s Garvan Institute and Brisbane’s QIMR Berghofer Medical Research Institute to detect the presence of a group of dormant cancer cells through blood tests. [South Australian Health and Medical Research Institute] Press Release CHA Biotech Wins Patent for Placenta-Derived Mesenchymal Stem Cells CHA Biotech said that it has obtained a patent for the use of placenta-derived mesenchymal stem cell lines. By acquiring the patent, the company has secured the right to develop treatments for degenerative neurological diseases using placental-derived mesenchymal stem cells. [Korea Biomedical Review] Press Release | |
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POLICY NEWSUC Faculty Members Quit Cell Press Editorial Boards over Impasse with Publisher Some of the University of California’s (UC’s) most prominent scientists have announced they will resign from editorial boards of Cell Press to protest the continuing impasse between its owner, publishing giant Elsevier, and UC over subscription costs and open access to articles. [ScienceInsider] Editorial Academia to FBI on Monitoring Chinese Scientists: “Tread Carefully” Nearly two dozen higher education groups warn the government to be cautious when advising US research universities to keep an eye on students and faculty with ties to certain Chinese institutions. [The Scientist] Editorial
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