Cord Blood News Volume 11.33 | Aug 29 2019

TOP STORY

An Epigenome-Wide Analysis of Cord Blood DNA Methylation Reveals Sex-Specific Effect of Exposure to Bisphenol A

The authors examined the association of prenatal bisphenol A exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children’s Health, using the Illumina HumanMethylation 450 BeadChip. [Sci Rep] Full Article

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A Prospective Observational Study of Immune Reconstitution following Transplantation with Post‐Transplant Reduced‐Dose Cyclophosphamide from HLA Haploidentical Donors

Investigators prospectively compared immune recovery patterns of lymphocyte subsets among four groups of adult patients with hematological disease who received hematopoietic cell transplantation from either HLA‐matched related or HLA‐matched unrelated donors, cord blood transplantation, or reduced‐dose post‐transplantation high‐dose cyclophosphamide. [Transpl Int] Abstract

Composite Membranes of Poly(ε-Caprolactone) with Bisphosphonate-Loaded Bioactive Glasses for Potential Bone Tissue Engineering Applications

The membranes exhibited excellent biocompatibility upon estimation of their cytotoxicity on Wharton’s jelly mesenchymal stromal cells (WJ-SCs), while they presented higher osteogenic potential in comparison with neat poly(ε-caprolactone) after WJ-SCs induced differentiation towards bone cells, which was enhanced by a possible synergistic effect of Sr and ibandronate. [Molecules] Full Article

Effects of Hepatocyte Growth Factor Gene-Transfected Mesenchymal Stem Cells on Dimethylnitrosamine-Induced Liver Fibrosis in Rats

Researchers investigated the therapeutic effect of hepatocyte growth factor-transfected human umbilical cord blood-derived MSCs on dimethylnitrosamine-induced liver fibrosis in rats. [Growth Factors] Abstract

Cartilage Regeneration in Osteoarthritic Knees Treated with Distal Femoral Osteotomy and Intra-Lesional Implantation of Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells: A Report of Two Cases

This case report presents the results of distal femoral osteotomy and human umbilical cord blood-derived MSC implantation for treating two patients with valgus deformity who had lateral compartment osteoarthritis. [Knee] Abstract

Mesenchymal Stromal Cells Lower Platelet Activation and Assist in Platelet Formation In Vitro

Scientists developed a potentially novel culture system for supporting platelet formation in vitro using a unique population of CD51⁺PDGFRα⁺ perivascular cells, derived from human umbilical cord tissue, which displayed numerous MSC properties. [JCI Insight] Full Article

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Mesenchymal Stem Cells in Allergic Diseases: Current Status

The authors focus on the discoveries and biological mechanisms of MSCs as a therapeutic tool in allergic diseases. They discuss the challenges of conducting MSC studies as well as future directions. [Allergol Int] Abstract

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Baylor Awarded CPRIT Grants to Support Cancer Research

Baylor College of Medicine has been awarded more than $17.4 million by the Cancer Prevention & Research Institute of Texas (CPRIT) to support new cancer research and programs, core facilities and recruitment of new faculty. More than 70 grants were awarded to institutions across Texas, totaling close to $136 million to advance the fight against cancer, including nine grants to Baylor College of Medicine. [Baylor College of Medicine] Press Release

IU School of Medicine Researcher Hal Broxmeyer Awarded IU President’s Medal

“Dr. Broxmeyer’s work in the area of human umbilical cord blood as a source of transplantable hematopoietic stem cells truly has been pioneering,” Indiana University (IU) President Michael A. McRobbie said. “His research has brought much closer the possibilities of a cure in some forms of cancer and blood diseases in children and adults.” [Indiana University School of Medicine] Press Release

Younger Scientists Need Better Support

Letters from research funders to university leaders rarely raise eyebrows. But a letter sent this month by the heads of the United Kingdom’s three largest medical-research funders did just that. [Nature News] Editorial

FDA Warns Testing Companies: Don’t Tell Patients How Their DNA Influences Response to Specific Drugs

Amid a boom in genetic testing that aims to predict a person’s response to medication, the FDA has been quietly pressuring a handful of companies to stop reporting results to patients about how their genes may interact with specific drugs. [STAT News] Editorial

Australia Plans to Tackle Foreign Influence at Nation’s Universities

In response to growing concerns in Australia about foreign influence at universities, cyberspying, and a perceived erosion of freedom of speech on campuses, the country’s education minister announced that a new task force will develop “best-practice guidelines for dealing with foreign interference.” [ScienceInsider] Editorial

NEW Stromal Cells in Immunity and Disease
February 19-23, 2020
Victoria, British Columbia, Canada

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NEW Postdoctoral Researcher – Cell Cycles in Stem Cells (University of California, Santa Cruz)

NEW Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Postdoctoral Scholarship – Human Erythropoiesis (Lund University)

Postdoctoral Scholarship – Computational Genomics and Bioinformatics (Lund University)

Postdoctoral Scholar – Gene and Cell Therapy (Stanford University)

Associate Professor – Pediatrics (Pennsylvania State University)

Early Stage Researchers – Hematopoiesis (Multiple Locations)

Faculty Positions – Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

PhD Positions – Age-Related Changes in Hematopoiesis (University of Milano-Bicocca)

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