Cord Blood News Volume 11.46 | Nov 28 2019

TOP STORY

Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Systemic Sepsis in Part by Enhancing Peritoneal Macrophage Bacterial Killing via Heme Oxygenase-1 Induction in Rats

Investigators tested the effects, dose-response, and mechanisms of action of cryopreserved, xenogeneic-free human umbilical cord MSCs in a rat model of fecal peritonitis, and examined the role of heme oxygenase-1 in protection. [Anesthesiology] Abstract

(Ranked by impact factor of the journal)

Intranasal Delivery of Human Umbilical Cord Wharton’s Jelly Mesenchymal Stromal Cells Restores Lung Alveolarization and Vascularization in Experimental Bronchopulmonary Dysplasia

Researchers examined the feasibility and effectiveness of human cord tissue‐derived MSC administration given via the intranasal route. Human umbilical cord tissue MSCs were isolated, characterized, and given intranasally to a hyperoxia‐induced rat model of bronchopulmonary dysplasia. [Stem Cells Transl Med] Full Article

Mechanism and Therapeutic Effect of Umbilical Cord Mesenchymal Stem Cells in Inflammatory Bowel Disease

Scientists provide an experimental model for elucidating the therapeutic effects of umbilical cord MSCs (UCMSCs) in inflammatory bowel disease (IBD). Thwy provide a theoretical basis and method for the clinical treatment of IBD using UCMSCs. [Sci Rep] Full Article

Comparison of the Chondrogenic Potential of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord Blood Intended for Cartilage Tissue Engineering

The authors compared the chondrogenic potential of equine MSCs derived from bone marrow and umbilical cord blood, at their undifferentiated status to check if one cell source is better proned, and after chondrogenic-induced differentiation. [Stem Cell Rev Rep] Abstract

Intracerebroventricular Delivery of Human Umbilical Cord Mesenchymal Stem Cells as a Promising Therapy for Repairing the Spinal Cord Injury Induced by Kainic Acid

Investigators used a validated spinal cord injury experimental model in which an intraparenchymal injection of kainic acid into the C5 segment of rat spinal cord induced an excitotoxic lesion. Three days later, experimental animals were treated with an intracerebroventricular injection of human umbilical cord MSCs whereas control group only received saline solution. [Stem Cell Rev Rep] Abstract

MicroRNA-29a Exhibited Pro-Angiogenic and Anti-Fibrotic Features to Intensify Human Umbilical Cord Mesenchymal Stem Cells-Renovated Perfusion Recovery and Preventing against Fibrosis from Skeletal Muscle Ischemic Injury

Scientists elucidated whether miR-29a and/or together with transplantation of mesenchymal stem cells isolated from umbilical cord Wharton’s jelly could aid in skeletal muscle healing and putative molecular mechanisms. [Int J Mol Sci] Full Article

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Growing Evidence Supporting the Use of Mesenchymal Stem Cell Therapies in Multiple Sclerosis: A Systematic Review

The authors conducted a systematic review to inquire into the safety, tolerability, and efficacy of MSC therapies in multiple sclerosis. [Mult Scler Relat Disord] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Innovative Public-Private Partnership Led by Harvard and MIT Aims to Bolster State’s Role as a Leading Region Globally for Life Sciences

An innovative new major private-public partnership led by Harvard and MIT aims to accelerate one of the hottest and most promising areas of medical research: cell and gene therapy. [The Harvard Gazette] Press Release

Hope Biosciences Receives FDA Approval to Commence Groundbreaking Clinical Trial for Alzheimer’s

Hope Biosciences announced that FDA has approved a Phase I/II clinical trial evaluating safety and efficacy of Hope Biosciences’ autologous, adipose-derived MSCs for Alzheimer’s disease, in partnership with Altoida, Inc. [Hope Biosciences] Press Release

PhD Students in China Report Misery and Hope

In a Nature survey, only 55% of the Chinese students who responded to the survey said that they were at least partially satisfied with their PhD experience. For the 5,630 respondents outside China, the satisfaction rate was 72% [Nature News] Editorial

Chinese Ministry Investigates Duplications in Papers by University President

The Chinese education ministry is investigating scientific articles authored by high-profile immunologist and university president Cao Xuetao, following suggestions that dozens of papers contain potentially problematic images. Four journals also say they are examining papers from Cao. [Nature News] Editorial

Stark Party Differences in ‘Brexit Election’ Could Shape Future of UK Science

When representatives of each party took to a stage last week at the Royal Society in London, they all promised increased funding and easier immigration for scientists. But Brexit loomed over the discussion, says Sarah Main, director of the Campaign for Science and Engineering, an advocacy group in London. [ScienceInsider] Editorial

NEW FGF Signaling: Understanding Function and Devising Therapeutic Tools
May 10-15, 2020
Lucca, Italy

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NEW Head of Laboratory – Cell Therapies (NHS Blood and Transplant)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Doctoral Student Position – Immunology and Gene Therapy (Karolinska Institutet)

Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

PhD Studentships – Molecular and Cell Biology (University of Oxford)

Faculty Position – Stem Cell Biology and Regenerative Medicine (Yale University School of Medicine)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

Group Leader – Vascular Biology, Hematopoiesis or Cardiovascular Disease (University of Wurzburg)

Postdoctoral Fellow – Normal and Malignant Hematopoiesis (Versiti Blood Research Institute)

PhD Positions – Cancer and Developmental Biology (Peter MacCallum Cancer Centre)

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