Cord Blood News Volume 11.48 | Dec 12 2019

TOP STORY

LncRNA ODIR1 Inhibits Osteogenic Differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX Axis

Researchers analyzed the lncRNA expression profile during osteogenic differentiation of human umbilical cord-derived-MSCs and identified a significantly downregulated lncRNA RP11-527N22.2, named osteogenic differentiation inhibitory lncRNA 1, ODIR1. [Cell Death Dis] Full Article

(Ranked by impact factor of the journal)

Wharton’s Jelly Mesenchymal Stem Cell-Based or Umbilical Vein Endothelial Cell-Based Serum-Free Coculture with Cytokines Supports the Ex Vivo Expansion/Maintenance of Cord Blood Hematopoietic Stem/Progenitor Cells

Investigators explored umbilical cord blood-CD34⁺ cell ex vivo expansion using Wharton’s jelly MSCs or umbilical vein endothelial cells as feeder layer-based serum-free coculture system with a cocktail of cytokines. [Stem Cell Res Ther] Full Article

A Novel Method to Improve the Osteogenesis Capacity of hUCMSCs with Dual‐Directional Pre‐Induction under Screened Co‐Culture Conditions

Researchers used osteogenic‐ and angiogenic‐differentiated hUCMSCs for co‐culture in screened culture medium to elevate the osteogenic capacity with in vitro studies and finally coupled with 3D TCP scaffold to repair rat’s critical‐sized calvarial bone defect. [Cell Prolif] Full Article

Adult Peripheral Blood and Umbilical Cord Blood NK Cells Are Good Sources for Effective CAR Therapy against CD19 Positive Leukemic Cells

The authors studied the efficacy of NK cells from adult peripheral blood and umbilical cord blood against different target cells in order to determine the best source for chimeric antigen receptor (CAR) therapy. [Sci Rep] Full Article

PDGFB-Expressing Mesenchymal Stem Cells Improve Human Hematopoietic Stem Cell Engraftment in Immunodeficient Mice

Scientists compared the effects of EGF, FGF2, and PDGFB on hematopoietic stem cell (HSC) regeneration using human MSCs that were transduced with these factors via lentiviral vectors. Among the above niche factors tested, MSCs transduced with PDGFB most significantly improved human HSC engraftment in immunodeficient mice. [Bone Marrow Transplant] Full Article

Increased In Vitro Migration of Human Umbilical Cord Mesenchymal Stem Cells toward Acellular Foreskin Treated with Bacterial Derivatives of Monophosphoryl Lipid A or Supernatant of Lactobacillus acidophilus

Human umbilical cord (MSCs) were isolated and cultured through acellular monophosphoryl lipid A- or supernatant of L. acidophilus-treated foreskin. Expression of some migration genes was also investigated using quantitative real-time reverse transcription polymerase chain reaction. [Hum Cell] Abstract

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Update on Mesenchymal Stromal Cell Studies in Organ Transplant Recipients

In clinical transplantation, allogeneic MSCs from bone marrow or umbilical cord have been evaluated in kidney and lung transplantation with an excellent safety profile. Recent data from kidney transplant patients given autologous bone marrow-MSC enrolled in a Phase I study demonstrated a good long term safety profile. [Curr Opin Organ Transplant] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Piramal Pharma Solutions Announces Collaboration with BerGenBio on the Development of FDA Fast Track Designated Leukemia Treatment

Piramal Enterprises Limited’s Pharma Solutions business announced that the company will be partnering with BerGenBio ASA on the development of bemcentinib for the treatment of elderly patients with relapsed acute myeloid leukemia. [Piramal Enterprises Limited’s Pharma Solutions (PR Newswire Association LLC.)] Press Release

Bristol-Myers Squibb Announces US FDA Breakthrough Therapy Designation for ORENCIA^® (Abatacept) to Help Prevent Acute Graft-versus-Host Disease, a Potentially Life-Threatening Complication after Stem Cell Transplant

Bristol-Myers Squibb Company announced that the FDA has granted Breakthrough Therapy Designation for ORENCIA^® for the prevention of moderate to severe acute graft-versus-host disease in HSC transplants from unrelated donors. [Bristol-Myers Squibb Company] Press Release

Rude Paper Reviews Are Pervasive and Sometimes Harmful, Study Finds

Peer reviewers are supposed to ensure that journals publish high-quality science by evaluating manuscripts and offering suggestions for improvement. But often, referee comments stray far from that mission, found the new PeerJ study, which surveyed 1106 scientists from 46 countries and 14 disciplines. More than half of the respondents reported receiving at least one “unprofessional” review, and a majority of those said they had received multiple problematic comments. [ScienceInsider] Editorial

Congress Set to Form Groups to Protect US Research Security

Congress is expected to approve an annual defense bill as early as this week that would create two federal bodies aimed at preventing foreign government influence in scientific research. [The Scientist] Editorial

US Scientists Who Hide Foreign Ties Should Face Research Misconduct Sanctions, Panel Says

US scientists who violate government rules on disclosing foreign research ties should be investigated for research misconduct, says an independent group of prominent scientists asked to examine the threat of foreign influences on the US research enterprise. [ScienceInsider] Editorial

NEW Tissue Stem Cell Regulation by Autonomous and Non-Autonomous Mechanisms
October 9-14, 2020
Hong Kong, China

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NEW Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

Professor – Regenerative Medicine (University of Southern Denmark)

Head of Laboratory – Cell Therapies (NHS Blood and Transplant)

Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center)

Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

PhD Studentships – Molecular and Cell Biology (University of Oxford)

Faculty Position – Stem Cell Biology and Regenerative Medicine (Yale University School of Medicine)

Research Assistant – Stem Cells and Engineering (New York Blood Center)

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