Cord Blood News 11.48 December 12, 2019 | |
| |
TOP STORYResearchers analyzed the lncRNA expression profile during osteogenic differentiation of human umbilical cord-derived-MSCs and identified a significantly downregulated lncRNA RP11-527N22.2, named osteogenic differentiation inhibitory lncRNA 1, ODIR1. [Cell Death Dis] Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Investigators explored umbilical cord blood-CD34+ cell ex vivo expansion using Wharton’s jelly MSCs or umbilical vein endothelial cells as feeder layer-based serum-free coculture system with a cocktail of cytokines. [Stem Cell Res Ther] Full Article Researchers used osteogenic‐ and angiogenic‐differentiated hUCMSCs for co‐culture in screened culture medium to elevate the osteogenic capacity with in vitro studies and finally coupled with 3D TCP scaffold to repair rat’s critical‐sized calvarial bone defect. [Cell Prolif] Full Article The authors studied the efficacy of NK cells from adult peripheral blood and umbilical cord blood against different target cells in order to determine the best source for chimeric antigen receptor (CAR) therapy. [Sci Rep] Full Article Scientists compared the effects of EGF, FGF2, and PDGFB on hematopoietic stem cell (HSC) regeneration using human MSCs that were transduced with these factors via lentiviral vectors. Among the above niche factors tested, MSCs transduced with PDGFB most significantly improved human HSC engraftment in immunodeficient mice. [Bone Marrow Transplant] Full Article Human umbilical cord (MSCs) were isolated and cultured through acellular monophosphoryl lipid A- or supernatant of L. acidophilus-treated foreskin. Expression of some migration genes was also investigated using quantitative real-time reverse transcription polymerase chain reaction. [Hum Cell] Abstract Subscribe to one of our other 19 science newsletters such as Hematopoiesis News & Cell Therapy News. | |
| |
REVIEWSUpdate on Mesenchymal Stromal Cell Studies in Organ Transplant Recipients In clinical transplantation, allogeneic MSCs from bone marrow or umbilical cord have been evaluated in kidney and lung transplantation with an excellent safety profile. Recent data from kidney transplant patients given autologous bone marrow-MSC enrolled in a Phase I study demonstrated a good long term safety profile. [Curr Opin Organ Transplant] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
| |
INDUSTRY NEWSPiramal Enterprises Limited’s Pharma Solutions business announced that the company will be partnering with BerGenBio ASA on the development of bemcentinib for the treatment of elderly patients with relapsed acute myeloid leukemia. [Piramal Enterprises Limited’s Pharma Solutions (PR Newswire Association LLC.)] Press Release Bristol-Myers Squibb Company announced that the FDA has granted Breakthrough Therapy Designation for ORENCIA® for the prevention of moderate to severe acute graft-versus-host disease in HSC transplants from unrelated donors. [Bristol-Myers Squibb Company] Press Release | |
| |
POLICY NEWSRude Paper Reviews Are Pervasive and Sometimes Harmful, Study Finds Peer reviewers are supposed to ensure that journals publish high-quality science by evaluating manuscripts and offering suggestions for improvement. But often, referee comments stray far from that mission, found the new PeerJ study, which surveyed 1106 scientists from 46 countries and 14 disciplines. More than half of the respondents reported receiving at least one “unprofessional” review, and a majority of those said they had received multiple problematic comments. [ScienceInsider] Editorial Congress Set to Form Groups to Protect US Research Security Congress is expected to approve an annual defense bill as early as this week that would create two federal bodies aimed at preventing foreign government influence in scientific research. [The Scientist] Editorial US Scientists Who Hide Foreign Ties Should Face Research Misconduct Sanctions, Panel Says US scientists who violate government rules on disclosing foreign research ties should be investigated for research misconduct, says an independent group of prominent scientists asked to examine the threat of foreign influences on the US research enterprise. [ScienceInsider] Editorial
| |
EVENTSNEW Tissue Stem Cell Regulation by Autonomous and Non-Autonomous Mechanisms Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Research Fellow – Stem Cell Biology & Engineering (New York Blood Center) Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine) Professor – Regenerative Medicine (University of Southern Denmark) Head of Laboratory – Cell Therapies (NHS Blood and Transplant) Research Fellow – Iron-Altered Hematopoiesis (New York Blood Center) Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine) PhD Studentships – Molecular and Cell Biology (University of Oxford) Faculty Position – Stem Cell Biology and Regenerative Medicine (Yale University School of Medicine) Research Assistant – Stem Cells and Engineering (New York Blood Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Cord Blood News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|