Cord Blood News Volume 12.01 | Jan 16 2020

TOP STORY

Human Umbilical Cord Perivascular Cells Improve Human Pancreatic Islet Transplant Function by Increasing Vascularization

Scientists manufactured human umbilical cord perivascular mesenchymal stromal cells (HUCPVCs) to Good Manufacturing Practice standards. HUCPVCs showed a stable phenotype while undergoing rapid ex vivo expansion at passage 2 to passage 4 and produced proregenerative factors, strongly suppressing T cell responses in the resting state and in response to inflammation. [Sci Transl Med] Abstract

(Ranked by impact factor of the journal)

Management of Retinitis Pigmentosa by Wharton’s Jelly Derived Mesenchymal Stem Cells: Preliminary Clinical Results

The authors aimed to determine if umbilical cord Wharton’s jelly derived MSCs implanted in sub-tenon space have beneficial effects on visual functions in retinitis pigmentosa patients by reactivating the degenerated photoreceptors in dormant phase. [Stem Cell Res Ther] Full Article

Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Transfers MicroRNA-19a to Protect Cardiomyocytes from Acute Myocardial Infarction by Targeting SOX6

Cardiac function related indicators, inflammatory factors and markers of myocardial injury, cardiomyocyte injury, infarct size, and apoptosis were detected in vivo experiments. The gain-and loss-of function was performed to evaluate the effects of human umbilical cord MSC-exo with down/upregulated miR-19a on acute myocardial infarction rats and hypoxic H9C2 cells. [Cell Cycle] Abstract

Human Amniotic Mesenchymal Stem Cells Alleviate Paraquat-Induced Pulmonary Fibrosis in Rats by Inhibiting the Inflammatory Response

Researchers investigated the therapeutic effects of human amniotic MSCs on paraquat-induced pulmonary fibrosis in rats and investigate the inflammatory mechanisms. [Life Sci] Abstract

Biosafety Evaluation of Equine Umbilical Cord-Derived Mesenchymal Stromal Cells (UC-MSCs) by Systematic Pathogen Screening in Peripheral Maternal Blood and Paired UC-MSCs

Investigators developed a standard protocol to ensure UC-MSC microbiological safety and to assess the risk of vertical transmission of common intracellular pathogens from broodmares to paired UC-MSCs. [Biopreserv Biobank] Abstract

Transplantation and Tracking of the Human Umbilical Cord Mesenchymal Stem Cell Labeled with Superparamagnetic Iron Oxide in Deaf Pigs

Researchers established a safe and effective approach to label the human umbilical cord MSCs derived from the Wharton’s Jelly with superparamagnetic iron oxide nanoparticles as a cell tracer. [Anat Rec] Abstract

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Potential of Mesenchymal Stem Cells for Bioengineered Blood Vessels in Comparison with Other Eligible Cell Sources

The authors survey the potential of MSCs for engineering functional blood vessels in comparison with other cell types including bone marrow mononuclear cells, endothelial precursor cells, differentiated adult autologous smooth muscle cells, autologous endothelial cells, embryonic stem cells, and induced pluripotent stem cells. [Cell Tissue Res] Abstract

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Tacitus Therapeutics Launches in Collaboration with Mount Sinai to Develop Stem Cell Therapies for Life-Threatening Diseases

Tacitus Therapeutics has launched in collaboration with the Mount Sinai Health System to develop stem cell therapies initially targeting blood cancers and related clotting disorders. Their first therapy, HSC100, currently is being investigated in a Phase I clinical trial. [Tacitus Therapeutics] Press Release

A Lifeline for Premature Born Babies: Funding Announced for New Stem Cell Research

RMIT is part a group of researchers from across the globe developing a new therapy that aims to see if stem cells can be used to regenerate the brain damage caused by premature birth. This brain damage is called ‘encephalopathy of prematurity’. [RMIT University] Press Release

NIH Extends Reporting Mandate to More Clinical Trials, but Obscures Their Policing

Many companies and medical research institutions fail to meet a long-standing legal mandate to disclose clinical trial results in a federal database. For certain trials, however, compliance is impossible to verify. [ScienceInsider] Editorial

Florida Cracks Down on Foreign Government Involvement in Research

Florida is launching a statewide investigation into US research exploitation after four University of Florida faculty members and six employees of Moffitt Cancer Center in Tampa failed to disclose ties to foreign programs, reports the Tampa Bay Times. [The Scientist] Editorial

NEW 15^th Swiss Stem Cell Network Annual Meeting
June 26, 2020
Bern, Switzerland

Visit our events page to see a complete list of events in the community.

NEW Research Fellow – Hematopoietic Diseases (University College London)

NEW Assistant or Associate Professor – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

NEW Senior Research Scientist – Stem Cell Biology and Disease Modeling (Tata Institute for Genetics and Society)

Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral and Scientist Position – Developmental Hematopoiesis and Gene Regulation (Icahn School of Medicine at Mount Sinai)

Research Assistant Professor – Hematology, Oncology and Blood & Marrow Transplantation (University of Iowa)

Postdoctoral Fellow – Cancer Immunotherapy/CAR T Cell Development (City of Hope)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Research Scholar – Hematologic Malignancies (Washington University School of Medicine)

Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine)

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