Dermal Cell News 6.04 February 3, 2020 | |
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TOP STORYTGFβ-Induced Epigenetic Deregulation of SOCS3 Facilitates STAT3-Signaling to Promote Fibrosis Scientists demonstrated that in fibrotic skin of patients with systemic sclerosis, a prototypical idiopathic fibrotic disease, transforming growth factor-β (TGFβ) induced the expression of DNA-methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts. [J Clin Invest] Abstract | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONInvestigators compared the relative disposition and local cytotoxicity of zinc oxide nanoparticles, and zinc ions formed on its dissolution, against keratinocyte cultures and in the human epidermis after application of suspensions of zinc oxide nanoparticles. [Nanotoxicology] Abstract OPN4 Belongs to the Photosensitive System of the Human Skin Ca2+ influx in vitro and ex vivo and phosphorylation of extracellular signal-regulated kinases 1/2 in human fibroblasts were observed by stimulation of blue light irradiation. [Genes Cells] Abstract SKIN CANCERS & DISORDERSUsing a genome-wide CRISPR screen in B16.SIY melanoma cells, researchers confirmed Ifngr2 and Jak1 as important genes conferring sensitivity to T cell-mediated killing in vitro. [Nat Commun] Full Article The authors performed high-throughput small molecule screens to identify bioactive compounds that synergize with tetrathiomolybdate in BRAFV600E-driven melanoma cells. [Cancer Res] Abstract | Full Article WDR74 Modulates Melanoma Tumorigenesis and Metastasis through the RPL5-MDM2-p53 Pathway Through gain- and loss-of-function approaches, WD repeat-containing protein 74 (WDR74) was found to promote cell proliferation, apoptosis resistance, and aggressive behavior in vitro. [Oncogene] Abstract Investigators showed that depending on the visible-light condition, the autophagic response of human melanoma A375 cells to nitrogen-doped titanium dioxide (N-TiO2) nanoparticles switched between two different statuses with the opposite outcomes. [J Cell Physiol] Abstract Following the initial growth phase, spheroids were treated with auristatin as small molecule or as antibody-drug conjugate containing non-leavable auristatin drug payload. [Sci Rep] Full Article Scientists analyzed ganglioside pattern on four melanoma and two neuroblastoma cell lines by high performance liquid chromatography (HPLC). They overexpressed β-1,4-N-acetyl-galactosaminyltransferase 1 (B4GALNT1) in the GM2/GD2-negative human melanoma cell line and confirmed production of GM2/GD2 by HPLC. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSSkin Interface, a Key Player for Borrelia Multiplication and Persistence in Lyme Borreliosis Numerous in vitro studies were conducted to better understand the role of specific skin cells and tick saliva in host defense, vector feeding, and pathogen transmission. The skin was also evidenced in various animal models as the site of bacterial multiplication and persistence. [Trends Parasitol] Abstract The authors, a group of clinical experts in the management of locally advanced basal cell carcinoma, summarize the clinical and pharmacological profiles of sonidegib and vismodegib based on published data and their own clinical experience. [J Eur Acad Dermatol Venereol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSMicroCures announced the advancement of its ongoing collaborative research project with the United States Army Institute of Surgical Research in the area of burn wound healing. [MicroCures, Inc.] Press Release Synedgen Receives $2.6 Million in Private Financing for Wound Care Portfolio Synedgen announced that it has received $2.6 million in private financing to fund the commercialization of Catasyn™ Advanced Technology Wound Hydrogel and SynePure™ Wound Cleanser, two FDA 510(k)-cleared products that form part of Synedgen’s Wound Care portfolio. [Synedgen, Inc.] Press Release | |
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POLICY NEWSScripps Acquires Pfizer’s Massive Microbial Library The East Coast campus of the research institute received shipments of freeze-dried or frozen samples of more than 210,000 microbial strains, which scientists plan to mine for potentially useful natural products. [The Scientist] Editorial Will Elizabeth Warren’s Stance against “Junk Science” Matter to Voters? Senator Elizabeth Warren of Massachusetts has come out with a proposal to keep so-called junk science, supported by industry, out of federal policy decisions. Many scientists have pointed out that misleading research and evidence, raised to new prominence under the Trump administration, has led to environmental and health policies that endanger the public. The coming week may tell whether Warren’s approach resonates with people in a bellwether state. [Scientific American] Editorial
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EVENTSNEW American Association for Cancer Research (AACR) Meeting: The Evolving Landscape of Cancer Modeling Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cancer Biology (Kentsis Research Group) Researcher – Dermatopathology (Weill Cornell Medical College) Postdoctoral Fellow – Cancer Pathogenesis (University of Cincinnati) Postdoctoral Position – Tissue Repair and Inflammation (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Cancer Research (University of California, San Diego) Research Fellow – Inherited Skin Conditions (University College London) Postdoctoral Fellowship – DNA Repair in Skin Melanoma Prevention (University of Southern California) Postdoctoral Position – Microbiota and Autoimmunity (The University of Arizona) Chief Position – Allergy, Immunology, Rheumatology and Dermatology (Harvard Medical School) Senior Associate Researcher – Inflammatory Skin Diseases (Icahn School of Medicine at Mount Sinai) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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