Dermal Cell News Volume 6.04 | Feb 03 2020

TOP STORY

TGFβ-Induced Epigenetic Deregulation of SOCS3 Facilitates STAT3-Signaling to Promote Fibrosis

Scientists demonstrated that in fibrotic skin of patients with systemic sclerosis, a prototypical idiopathic fibrotic disease, transforming growth factor-β (TGFβ) induced the expression of DNA-methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts. [J Clin Invest] Abstract | Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Disposition and Measured Toxicity of Zinc Oxide Nanoparticles and Zinc Ions against Keratinocytes in Cell Culture and Viable Human Epidermis

Investigators compared the relative disposition and local cytotoxicity of zinc oxide nanoparticles, and zinc ions formed on its dissolution, against keratinocyte cultures and in the human epidermis after application of suspensions of zinc oxide nanoparticles. [Nanotoxicology] Abstract

OPN4 Belongs to the Photosensitive System of the Human Skin

Ca²⁺ influx in vitro and ex vivo and phosphorylation of extracellular signal-regulated kinases 1/2 in human fibroblasts were observed by stimulation of blue light irradiation. [Genes Cells] Abstract

SKIN CANCERS & DISORDERS

Tumor Heterogeneity and Clonal Cooperation Influence the Immune Selection of IFN-γ-Signaling Mutant Cancer Cells

Using a genome-wide CRISPR screen in B16.SIY melanoma cells, researchers confirmed Ifngr2 and Jak1 as important genes conferring sensitivity to T cell-mediated killing in vitro. [Nat Commun] Full Article

Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma

The authors performed high-throughput small molecule screens to identify bioactive compounds that synergize with tetrathiomolybdate in BRAFV600E-driven melanoma cells. [Cancer Res] Abstract | Full Article

WDR74 Modulates Melanoma Tumorigenesis and Metastasis through the RPL5-MDM2-p53 Pathway

Through gain- and loss-of-function approaches, WD repeat-containing protein 74 (WDR74) was found to promote cell proliferation, apoptosis resistance, and aggressive behavior in vitro. [Oncogene] Abstract

Differential Effects of N-TiO₂ Nanoparticle and Its Photo-Activated Form on Autophagy and Necroptosis in Human Melanoma A375 Cells

Investigators showed that depending on the visible-light condition, the autophagic response of human melanoma A375 cells to nitrogen-doped titanium dioxide (N-TiO₂) nanoparticles switched between two different statuses with the opposite outcomes. [J Cell Physiol] Abstract

Effects of Microtubule-Inhibiting Small Molecule and Antibody-Drug Conjugate Treatment on Differentially-Sized A431 Squamous Carcinoma Spheroids

Following the initial growth phase, spheroids were treated with auristatin as small molecule or as antibody-drug conjugate containing non-leavable auristatin drug payload. [Sci Rep] Full Article

B4GALNT1 Induces Angiogenesis, Anchorage Independence Growth and Motility, and Promotes Tumorigenesis in Melanoma by Induction of Ganglioside GM2/GD2

Scientists analyzed ganglioside pattern on four melanoma and two neuroblastoma cell lines by high performance liquid chromatography (HPLC). They overexpressed β-1,4-N-acetyl-galactosaminyltransferase 1 (B4GALNT1) in the GM2/GD2-negative human melanoma cell line and confirmed production of GM2/GD2 by HPLC. [Sci Rep] Full Article

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Skin Interface, a Key Player for Borrelia Multiplication and Persistence in Lyme Borreliosis

Numerous in vitro studies were conducted to better understand the role of specific skin cells and tick saliva in host defense, vector feeding, and pathogen transmission. The skin was also evidenced in various animal models as the site of bacterial multiplication and persistence. [Trends Parasitol] Abstract

Sonidegib and Vismodegib in the Treatment of Patients with Locally Advanced Basal Cell Carcinoma: A Joint Expert Opinion

The authors, a group of clinical experts in the management of locally advanced basal cell carcinoma, summarize the clinical and pharmacological profiles of sonidegib and vismodegib based on published data and their own clinical experience. [J Eur Acad Dermatol Venereol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Microcures Advances Burn Wound Healing Program under Cooperative Research and Development Agreement (CRADA) with the US Army Institute of Surgical Research (USAISR)

MicroCures announced the advancement of its ongoing collaborative research project with the United States Army Institute of Surgical Research in the area of burn wound healing. [MicroCures, Inc.] Press Release

Synedgen Receives $2.6 Million in Private Financing for Wound Care Portfolio

Synedgen announced that it has received $2.6 million in private financing to fund the commercialization of Catasyn^™ Advanced Technology Wound Hydrogel and SynePure^™ Wound Cleanser, two FDA 510(k)-cleared products that form part of Synedgen’s Wound Care portfolio. [Synedgen, Inc.] Press Release

Scripps Acquires Pfizer’s Massive Microbial Library

The East Coast campus of the research institute received shipments of freeze-dried or frozen samples of more than 210,000 microbial strains, which scientists plan to mine for potentially useful natural products. [The Scientist] Editorial

Will Elizabeth Warren’s Stance against “Junk Science” Matter to Voters?

Senator Elizabeth Warren of Massachusetts has come out with a proposal to keep so-called junk science, supported by industry, out of federal policy decisions. Many scientists have pointed out that misleading research and evidence, raised to new prominence under the Trump administration, has led to environmental and health policies that endanger the public. The coming week may tell whether Warren’s approach resonates with people in a bellwether state. [Scientific American] Editorial

NEW American Association for Cancer Research (AACR) Meeting: The Evolving Landscape of Cancer Modeling
March 2-5, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Cancer Biology (Kentsis Research Group)

Researcher – Dermatopathology (Weill Cornell Medical College)

Postdoctoral Fellow – Cancer Pathogenesis (University of Cincinnati)

Postdoctoral Position – Tissue Repair and Inflammation (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Cancer Research (University of California, San Diego)

Research Fellow – Inherited Skin Conditions (University College London)

Postdoctoral Fellowship – DNA Repair in Skin Melanoma Prevention (University of Southern California)

Laboratory Research Scientist – Advanced Sequencing Facility in Melanoma (The Francis Crick Institute)

Postdoctoral Position – Microbiota and Autoimmunity (The University of Arizona)

Chief Position – Allergy, Immunology, Rheumatology and Dermatology (Harvard Medical School)

Senior Associate Researcher – Inflammatory Skin Diseases (Icahn School of Medicine at Mount Sinai)

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