Extracellular Matrix News Volume 11.08 | Mar 5 2020

TOP STORY

FGF9 and FGF10 Activate Distinct Signaling Pathways to Direct Lung Epithelial Specification and Branching

Researchers found that fibroblast growth factor (FGF)9 signaled through epithelial FGF receptor 3 to directly promote distal epithelial fate specification and inhibit epithelial differentiation. [Sci Signal] Abstract

(Ranked by impact factor of the journal)

Hypoxia-Induced lncRNA PDIA3P1 Promotes Mesenchymal Transition via Sponging of miR-124-3p in Glioma

Scientists found that protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P1) expression was closely related to tumor degree, transcriptome subtype, and prognosis in glioma patients. [Cell Death Dis] Full Article

Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF-2

Investigators showed that human mesenchymal stromal cells (MSCs) secreted ECM proteins into the pericellular space early after encapsulation and that, even in the absence of material-presented cell adhesion motifs, cell-derived fibronectin enabled cell spreading. [Adv Healthc Mater] Abstract

A Comprehensive Comparison of Bovine and Porcine Decellularized Pericardia: New Insights for Surgical Applications

The authors compared the mostly applied pericardia in clinics, i.e. bovine and porcine tissues, after their decellularization, and obtained new insights for their possible surgical use. [Biomolecules] Full Article

Oxidative Stress Enhanced the Transforming Growth Factor-β2-Induced Epithelial-Mesenchymal Transition through Chemokine Ligand 1 on ARPE-19 Cell

TGF-β2 induced the upregulation of epithelial-mesenchymal transformation markers including α-smooth muscle actin, Snail, and Slug and downregulation of E-cadherin in ARPE-19 cells. [Sci Rep] Full Article

Paclitaxel-Induced Peripheral Neuropathy Is Caused by Epidermal ROS and Mitochondrial Damage through Conserved MMP-13 Activation

Scientists assessed mitochondrial damage and reactive oxygen species (ROS) formation as possible inducers of matrix-metalloproteinase (MMP)-13, and they analyzed MMP-13-dependent damage. [Sci Rep] Full Article

Bioactive Glass (BG) ICIE16 Shows Promising Osteogenic Properties Compared to Crystallized 45S5-BG

The influence of ICIE16-BG on viability, proliferation, and osteogenic differentiation of human mesenchymal stromal cells was evaluated in direct comparison to 45S5-BG. [Int J Mol Sci] Abstract | Full Article

Influence of the Integrin Alpha-1 Subunit and Its Relationship with High-Fat Diet upon Extracellular Matrix Synthesis in Skeletal Muscle and Tendon

Researchers investigated whether the deletion of the integrin receptor α1 subunit influenced collagen and other matrix proteins in musculotendinous tissue and whether it caused any compensatory changes in other integrin subunits in C57BL/6J mice. [Cell Tissue Res] Abstract

Induced Cell Migration Based on a Bio-Active Hydrogel Sheet Combined with a Perfused Microfluidic System

Investigators report a new method for maintaining cell viability and inducing cell migration using a perfused microfluidic platform based on collagen gel and a gradient hydrogel sheet. [Biomed Mater] Abstract

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Neurons, Glia, Extracellular Matrix and Neurovascular Unit: A Systems Biology Approach to the Complexity of Synaptic Plasticity in Health and Disease

The authors propose that a better interpretation of the central nervous system complexity can be granted by a systems biology approach through the construction of predictive molecular models that enlighten the regulatory logic of the complex molecular networks underlying brain function in health and disease, thus opening the way to more effective treatments. [Int J Mol Sci] Abstract | Full Article

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Synedgen Announces $1 Million Award from Defense Health Agency to Develop SynePure and Catasyn

Synedgen announced a combined $1 million award from the Defense Health Agency (DHA) Small Business Innovation Research Program (SBIR), along with additional research funds from the DHA, to commercialize its products, SynePure™ Wound Cleanser and Catasyn™ Advanced Technology Wound Hydrogel, developed under DHA SBIR award W81XWH-16-C-0023. [Synedgen] Press Release

First Patient Enrolled in AVITA Medical’s Pivotal Study Evaluating RECELL System for Soft Tissue Reconstruction

AVITA Medical Limited announced the initiation of a pivotal study for soft tissue reconstruction with the enrollment of the first patient at the Arizona Burn Center at Valleywise Medical Health Center in Phoenix. [AVITA Medical Limited] Press Release

China Bans Cash Rewards for Publishing Papers

Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial

UC Santa Cruz Fires Graduate Students Taking Part in Strike

The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial

NEW Gordon Research Conference: Diverse Organisms and Common Mechanisms in Cell-Cell Fusion
May 31-June 5, 2020
Easton, Massachusetts, United States

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NEW Department Head – Biochemistry and Molecular Genetics (University of Illinois College of Medicine)

Postdoctoral Researcher – Myometrial ECM (University of Vermont)

Investigator – Single Cell Genomics (GlaxoSmithKline USA)

Researcher – Biomaterials Scientist (Aspect Biosystems)

Postdoctoral Researchers – Regulatory RNA and Cell-Cell Communication (Brigham and Women’s Hospital)

Postdoctoral Fellow – Mechanisms of TGF-Beta Activiation (Genentech, Inc.)

Postdoctoral Fellow – Extracellular Superoxide Dismutase (Vascular Biology Center)

Research Associate – Oncology (Zymeworks, Inc.)

Research Scientist – Tumor Microenvironment (Systimmune, Inc.)

Scientist – Regenerative Medicine (Xtant Medical, Inc.)

Master Thesis – Hydrogels and Microfluid Environments (Karlsruhe Institute of Technology)

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