Endothelial Cell News Volume 4.31 | Sep 16 2019

TOP STORY

Tazarotene Released from Aligned Electrospun Membrane Facilitates Cutaneous Wound Healing by Promoting Angiogenesis

An in vitro study demonstrated that compared with the random drug-loaded or other control groups, the aligned tazarotene-loaded membranes could stimulate the proliferation, migration, angiogenesis, VEGF secreting and its gene expression of HUVECs. [ACS Appl Mater Interfaces] Abstract

(Ranked by impact factor of the journal)

Fibroblast Growth Factor 21 Ameliorates Diabetes-Induced Endothelial Dysfunction in Mouse Aorta via Activation of the CaMKK2/AMPKα Signaling Pathway

In vitro, scientists identified a direct action of fibroblast growth factor (FGF) 21 on endothelial cells of the aorta, in which it bound to FGF receptors to alleviate impaired endothelial function challenged with high glucose. [Cell Death Dis] Full Article

Icariin Promotes Angiogenesis in Glucocorticoid-Induced Osteonecrosis of Femoral Heads: In Vitro and In Vivo Studies

Icariin significantly promoted bone microvascular endothelial cells migration, tube formation, the angiogenesis-related cytokines expression and the activation of Akt. [J Cell Mol Med] Full Article

Prostaglandin E2 Receptor EP1 (PGE2/EP1) Deletion Promotes Glomerular Podocyte and Endothelial Cell Injury in Hypertensive TTRhRen Mice

Ultrastructural injury to podocytes and glomerular endothelium was prominent in hypertensive TTRhRen EP1^−/− mice; including widened subendothelial space, subendothelial lucent zones and focal lifting of endothelium from basement membrane, with focal subendothelial cell debris. [Lab Invest] Abstract

Blockade of Intercellular Adhesion Molecule-1 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction

Blocking intercellular adhesion molecule-1 with a neutralizing antibody significantly attenuated angiotensin II-induced arterial hypertension, vascular hypertrophy, fibrosis, macrophage infiltration, and reactive oxygen species production and improved vascular relaxation. [Lab Invest] Abstract

Liver Sinusoidal Endothelial Cell ICAM-1 Mediated Tumor/Endothelial Crosstalk Drives the Development of Liver Metastasis by Initiating Inflammatory and Angiogenic Responses

To elucidate the role of intercellular adhesion molecule-1 (ICAM-1) on the crosstalk between tumor and primary liver sinusoidal endothelial cells and hepatic stellate cells, implicated in tumor adhesion and angiogenesis, investigators performed in vitro cocultures and an in vivo model of liver metastasis of colorectal cancer. [Sci Rep] Full Article

Interplay of Plasmodium falciparum and Thrombin in Brain Endothelial Barrier Disruption

Researchers examined how mature-stage P. falciparum infected erythrocytes interacted with tumor necrosis factor α and thrombin in the activation and permeability of primary human brain microvascular endothelial cell monolayers. [Sci Rep] Full Article

PEGylated Gold Nanorods Are Not Cytotoxic to Human Endothelial Cells but Affect Kruppel-Like Factor Signaling Pathway

Scientists investigated the toxicity of PEGylated gold nanorods to HUVECs, a commonly used in vitro model for human endothelium. [Toxicol Appl Pharmacol] Abstract

Antiangiogenesis Effect of Timosaponin AIII on HUVECs In Vitro and Zebrafish Embryos In Vivo

The authors demonstrated that timosaponin AIII treatment significantly suppressed the expression of VEGF receptor and the phosphorylation of Akt, MEK1/2, and ERK1/2 in HUVECs. [Acta Pharmacol Sin] Abstract

Growth Hormone-Releasing Hormone Promotes Therapeutic Effects of Peripheral Blood Endothelial Progenitor Cells in Ischemic Repair

Growth hormone-releasing hormone enhanced the proliferation, migration, and angiogenesis capacity of peripheral blood-endothelial progenitor cells and reduced apoptosis under H₂O₂ stimulation. [J Endocrinol Invest] Abstract

Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News.

Endothelial Targets in Stroke

Investigators focused on current preclinical studies examining how to prevent ischemia-induced endothelial dysfunction. [Arterioscler Thromb Vasc Biol] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

AVEO Oncology Announces Updated Overall Survival Hazard Ratio of 0.99 in Phase III TIVO-3 Trial of Tivozanib in Renal Cell Carcinoma

AVEO Oncology announced results from the second prespecified analysis of overall survival in the TIVO-3 trial. TIVO-3 is the company’s Phase III randomized, controlled, multi-center, open-label study to compare tivozanib to sorafenib in 350 subjects with highly refractory metastatic renal cell carcinoma. [AVEO Oncology] Press Release

First Patient Enrolled in Cook Regentec’s Clinical Trial of Investigational Therapy for Critical Limb Ischemia

Cook Regentec announced enrollment of the first patient in an international clinical trial evaluating the HemaTrate^® Blood Filtration System to treat patients with critical limb ischemia due to peripheral arterial disease. [Cook Regentec (Business Wire, Inc.)] Press Release

Science under Maximum Pressure in Iran

From travel restrictions and publishing bans to currency collapse, the restoration of US sanctions has left researchers in Iran reeling. [The Scientist] Editorial

EU Research Commissioner Named, but Lacks ‘Research’ in Her Title

Mariya Gabriel, a conservative politician from Bulgaria, is slated to become the next European research chief- although her job title, unlike that of her predecessors, doesn’t include the words “research” or “science”. [ScienceInsider] Editorial

NEW NF-kB, JAK-STAT & MAPK in Health, Disease & Therapy
October 7-11, 2019
Suzhou, China

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Liver Macrophage Niche (Flanders Institute for Biotechnology)

NEW Postdoctoral Position – Alzheimer’s disease (Icahn School of Medicine)

NEW Postdoctoral Position – Vascular Biology (New York University Winthrop Hospital)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Science Manager – Vascular Biology (Max Delbrück Center for Molecular Medicine)

PhD and Postdoctoral Positions – Neurovascular Biology (Université Libre de Bruxelles)

Research Fellow – Vascular Stem Cell Biology (Queen’s University Belfast)

Postdoctoral Position – Endothelial Cell Research (The University of Tennessee Health Science Center)

Faculty Positions – Basic and Translational Cardiovascular Sciences (New York University)

Postdoctoral Fellow – Cardiovascular Physiology (University of California, San Diego)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Endothelial Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.