Endothelial Cell News 5.01 January 13, 2020 | |
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TOP STORYThe Entry of Nanoparticles into Solid Tumors Researchers showed that inter-endothelial gaps were not responsible for the transport of nanoparticles into solid tumors. Instead, they found that up to 97% of nanoparticles entered tumors using an active process through endothelial cells. [Nat Mater] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists single-cell RNA-sequenced 56,771 endothelial cells from human/mouse (peri)-tumoral lung and cultured human lung tumor endothelial cell (TECs), and detected 17 known and 16 previously unrecognized phenotypes, including TECs putatively regulating immune surveillance. [Cancer Cell] Abstract | Graphical Abstract Investigators present a microphysiological platform that recapitulated the key structure and function of the human blood-brain barrier and enabled 3D mapping of nanoparticle distributions in the vascular and perivascular regions. [Nat Commun] Full Article Neutrophil Microvesicles Drive Atherosclerosis by Delivering miR-155 to Atheroprone Endothelium Using cultured endothelial cells exposed to disturbed flow, the authors demonstrated that neutrophil microvesicles promoted inflammatory gene expression by delivering miR-155, enhancing NF-κB activation. [Nat Commun] Full Article Nitro-oleate increased migration in endothelial cells isolated from wild-type mice, but not those from C521S soluble epoxide hydrolase knock-in transgenic mice genetically modified to render the hydrolase electrophile-resistant. [Redox Biol] Full Article | Graphical Abstract The CXCR2/CXCL2 Signaling Pathway – An Alternative Therapeutic Approach in High-Grade Glioma In vitro analyses of CXCR2-antagonist (SB225002) showed its direct impact on proliferation of glioma and endothelial cells if used at higher concentrations. In addition, expression of CXCR2/CXCL2 signaling genes was increased in both cell types by SB225002, but VEGF-relevant genes were unaffected. [Eur J Cancer] Abstract Skip Is Essential for Notch Signaling to Induce Sox2 in Cerebral Arteriovenous Malformations Investigators identified high expression of ski-interacting protein (Skip) in brain endothelial cells (ECs), a Notch-associated chromatin-modifying protein that was lacking in lung ECs. [Cell Signal] Abstract Cell migration, proliferation, and tube formation of endothelial cells were induced by treatment with anosmin-1 as well as vascular endothelial growth factor-A, and further enhanced by treatment with both of them. [Sci Rep] Full Article Scientists showed that exosomal miR-146a-5p was efficiently transported into endothelial cells, reducing monocyte transendothelial migration and endothelial permeability by targeting junctional adhesion molecule C (JAM-C). [Exp Cell Res] Abstract | Graphical Abstract Researchers explored the effect of miR-384-5p on proliferation, apoptosis, and angiogenesis of endothelial progenitor cells in cerebral ischemic stroke and investigated the associated underlying mechanism. [Cerebrovasc Dis] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSThe authors summarize the current knowledge on the crosstalk between tubular epithelial cells and glomerular endothelial cells in the pathogenesis of diabetic kidney disease and highlight specific clinical and potential therapeutic strategies. [Cell Prolif] Full Article The Effects of Diabetes Mellitus on the Corneal Endothelium: A Review Scientists discuss the specifics of how diabetes mellitus impacts the corneal endothelium including alterations in cell morphology, cell density, ultrastructure, pump and barrier function, cataract surgery outcomes, and corneal transplant outcomes with attention to the use of diabetic donor tissue and diabetic transplant recipients. [Surv Ophthalmol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSMereo BioPharma and Oncologie Enter into Global Licensing Agreement for Navicixizumab Mereo BioPharma Group plc and Oncologie, Inc. announced a global license agreement for the development and commercialization of navicixizumab, an anti-DLL4/VEGF bispecific antibody currently being evaluated in an ongoing Phase Ib study in combination with paclitaxel in patients with advanced heavily pretreated ovarian cancer. [Mereo BioPharma Group plc] Press Release Exonate announced that it has entered into a strategic collaboration agreement with Janssen Pharmaceuticals, Inc. Through the collaboration, Exonate will work with Janssen Research & Development, LLC scientists to develop an eye drop treatment for retinal vascular diseases such as wet AMD and DMO by using mRNA targeted therapies. [Exonerate Ltd. (PR Newswire Association LLC)] Press Release IDEAYA Biosciences, Inc. announced that the company has entered into a Sponsored Research Agreement with Boston Children’s Hospital for preclinical evaluation of the role of protein kinase C in Sturge Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations and associated with mutations in GNAQ. [IDEAYA Biosciences, Inc.] Press Release | |
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POLICY NEWSFDA and NIH Let Clinical Trial Sponsors Keep Results Secret and Break the Law For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. Few trial sponsors have consistently done so, even after a 2007 law made posting mandatory for many trials registered in the database. [ScienceInsider] Editorial Predatory-Journal Papers Have Little Scientific Impact Papers published in ‘predatory’ journals attract little attention from scientists, and get cited much less than those in reputable publications, an analysis shows. Predatory journals are those that charge authors high article-processing fees but don’t provide expected publishing services, such as peer review or other quality checks. [Nature News] Editorial
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Endothelial Biology (City of Hope) NEW Postdoctoral Researcher (University of Illinois at Chicago) NEW Tenure Track Faculty – Endothelial Cell Regeneration (Ohio State University) NEW Postdoctoral Position (University Hospital of Muenster) NEW PhD Student (University Hospital Carl Gustav Carus Dresden) Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital) PhD Student – Aortic Disease (University Hospital of Cologne) Postdoctoral Research Fellow – Aortic Disease (University Hospital of Cologne) Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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