Human Immunology News 7.25 July 2, 2019 | |
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TOP STORYImmune Evasion before Tumor Invasion in Early Lung Squamous Carcinogenesis Scientists showed that immune activation and immune escape occur before tumor invasion, and revealed the relevant immune biomarkers of the pre-invasive stages of carcinogenesis in the lung. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Using a genetic approach complemented by adoptive transfer, researchers found that neutrophils were essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. [Cell] Full Article | Graphical Abstract The authors report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. [Nat Immunol] Abstract Investigators report that pediatric patients with acute lymphoblastic leukemia have tumor-associated neoepitope-specific CD8+ T cells, responding to 86% of tested neoantigens and recognizing 68% of the tested neoepitopes. [Sci Transl Med] Abstract | Press Release Single-Cell Transcriptomic Analysis of Tissue-Resident Memory T Cells in Human Lung Cancer Single-cell and bulk transcriptomic analysis of tissue-resident memory T (TRM) and non-TRM cells present in tumor and normal lung tissue from patients with lung cancer revealed that PD-1-expressing TRM cells in tumors were clonally expanded and enriched for transcripts linked to cell proliferation and cytotoxicity when compared with PD-1-expressing non-TRM cells. [J Exp Med] Abstract | Graphical Abstract Scientists investigated the role of P-selectin and its receptor P-selectin glycoprotein ligand (PSGL)-1 on atherosclerosis via activation of dendritic cells. [Cell Death Dis] Full Article To understand mechanisms regulating bispecific T cell engager (BiTE) molecule-mediated CD8+ T cell activity against solid tumors, investigators sought to define human CD8+ T cell populations that efficiently respond to BiTE molecule stimulation and identify factors regulating their cytolytic activity. [J Immunol] Abstract | Full Article Elevated Numbers of PD-L1 Expressing B Cells Are Associated with the Development of AIDS-NHL Researchers assessed B cell programmed cell death ligand-1 (PD-L1) expression on B cells preceding AIDS-related non-Hodgkin lymphoma (AIDS-NHL) diagnosis in a nested case-control study of HIV+ subjects who went on to develop AIDS-NHL, as well as HIV+ subjects who did not, using multi-color flow cytometry. [Sci Rep] Full Article The authors investigated the consequences of co-incubation with K562, CTV-1, Daudi RPMI-8226, and MCF-7 tumor cell lines on the phenotype, cytokine expression profile, and transcriptome of human natural killer cells. [PLoS One] Full Article Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSTissue-Resident Memory T Cells in Cancer Immunosurveillance The authors highlight defining features of tumor-localizing tissue-resident CD8+ memory T cells, examine the mechanisms through which they have recently been shown to suppress cancer growth, and explore their potential as future targets of cancer immunotherapy. [Trends Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSVycellix™, Inc. announced that the company has been included as a collaborative partner in the new Competence Center for Next-Generation NK Cell-based Cancer Immunotherapy being established at Karolinska Institutet. [Vycellix™, Inc.] Press Release OncoSec Medical Incorporated announced that it has entered into a collaboration with Dana-Farber Cancer Institute and The Marasco Laboratory to develop CAR T-cell therapies for triple-negative breast cancer and other solid tumor cancers. [OncoSec Medical Incorporated (PR Newswire Association LLC)] Press Release | |
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POLICY NEWSExclusive: FDA Enforcement Actions Plummet Under Trump From monitoring clinical trials and approving medicines and vaccines, to ensuring the safety of blood transfusions, medical devices, groceries, and more, the FDA is one of the nation’s most vital watchdogs. By several measures, however, FDA’s compliance and enforcement actions have plummeted since President Donald Trump took office, Science has found. [ScienceInsider] Editorial Germany’s Prestigious Max Planck Society Conducts Huge Bullying Survey Most of the scientists who work for one of the world’s richest and most prestigious basic research organizations, the Max Planck Society (MPS) in Germany, have pride and trust in their institutes — but cases of sexual discrimination and bullying occur regularly, and nearly half of foreign scientists working for the MPS don’t feel they fit in. [Nature News] Editorial Taiwan to Crack Down on Unauthorized Research Collaborations With Mainland China According to Taiwan’s Central News Agency, the island’s government is investigating seven researchers for allegedly joining a prestigious program sponsored by the mainland China government to lure academics to the mainland without the necessary permissions. [Nature News] Editorial India Culls Hundreds More ‘Dubious’ Journals From Government Approved List A rise in Indian scientists publishing research in low-quality journals prompted the University Grants Commission to create a ‘white list’ of approved journals in 2017. Universities use the list to evaluate researchers for promotion and hiring. [Nature News] Editorial
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EVENTSNEW 17th International Congress of Immunology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Scientist – Molecular Immunology (Babraham Institute) NEW PhD Fellowship – Immunology (University of Oslo) Postdoctoral Fellow – Tumor Immunology (Massachusetts General Hospital and Harvard Medical School) Senior Research Assistant – Immunology (MD Anderson Cancer Center) Postdoctoral Fellow – Immunology (Boston University) Postdoctoral Position – Immunology of Enteric Infections (University of Utah) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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