Mesenchymal Cell News Volume 12.00 | Jan 7 2020

TOP STORY

Acquisition of a Unique Mesenchymal Precursor-Like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration

Scientists showed that Pdgfra-expressing MSCs in uninjured digits established the regenerative blastema and were essential for regeneration. [Dev Cell] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

IN VITRO

Inflammation-Induced Inhibition of Chaperone-Mediated Autophagy Maintains the Immunosuppressive Function of Murine Mesenchymal Stromal Cells

Suppression of chaperone-mediated autophagy (CMA) by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2 (LAMP-2A) in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation, and as expected, LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation. [Cell Mol Immunol] Full Article

Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans

Researchers showed that an fibroblast growth factor 2-binding heparan sulfate variant accelerated the expansion of freshly isolated bone marrow human MSCs without compromising their naivety. [Stem Cell Reports] Full Article

Influence of Mesenchymal Stem Cell-Derived Extracellular Vesicles In Vitro and Their Role in Aging

Incubation with young MSC-derived extracellular vesicles decreased the levels of aging markers and components of the mTOR pathway and increased the pluripotency markers from old MSC populations. [Stem Cell Res Ther] Full Article

Alteration of Fatty Acid Oxidation by Increased CPT1A on Replicative Senescence of Placenta-Derived Mesenchymal Stem Cells

Long-term cultivation of placenta-derived-MSCs exhibited increases of senescent markers such as SA-β-gal and p21 including apoptotic factor, and decreases of proliferation, differentiation potential, and survival factor. [Stem Cell Res Ther] Full Article

Adipose-Derived Mesenchymal Stromal Cells Modulate Lipid Metabolism and Lipid Droplet Biogenesis via AKT/mTOR-PPARγ Signaling in Macrophages

Scientists demonstrated major effects of MSC conditioned medium to reprogram macrophage immunometabolism through mTOR and PPARγ dependent and independent pathways. [Sci Rep] Full Article

Human Mesenchymal Stem Cells Are Resistant to UV-B Irradiation

MSCs exhibited higher clonogenic survival, proliferative activity and viability than dermal fibroblasts after exposure to UV-B irradiation. Cellular adhesion, morphology and expression of characteristic surface marker patterns remained largely unaffected in UV-irradiated MSCs. [Sci Rep] Full Article

Human Lung Epithelial BEAS-2B Cells Exhibit Characteristics of Mesenchymal Stem Cells

Both BEAS-2B and human umbilical cord-derived MSC 1 shared the same expression profile of surface markers of hMSCs and exhibited similar osteogenic and adipogenic differentiation potential. [PLoS One] Abstract

IN VIVO

Melatonin Rescues Osteoporosis by Upregulating BMMSCs’ Osteogenic Ability but Suppressing BMMSC-Mediated Osteoclastogenesis via MT2-Inactivated NF-κB Pathway

Melatonin played a crucial role in bone balance, significantly accelerated the osteogenic differentiation of bone marrow MSCs (BMMSCs) by suppressing the MT2-dependent NF-κB signaling pathway, and downregulated osteoclastogenesis via receptor activator of nuclear factor-κB ligand paracrine secretion. [Br J Pharmacol] Abstract

Endothelial Progenitor Cells Promote Viability and Nerve Regenerative Ability of Mesenchymal Stem Cells through PDGF-BB/PDGFR-β Signaling

Investigators revealed that PDGF-BB significantly increased the proportion of PDGFR-β⁺ MSCs, and promoted both in vitro and in vivo viability, as well as nerve regenerative capacity and erectile function restoration of MSCs in rats. [Aging (Albany NY)] Full Article

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Angiotensin Receptor Subtypes Regulate Adipose Tissue Renewal and Remodeling

The authors summarize current data regarding the regulation of adipose tissue renewal and particularly adipose-derived mesenchymal stem/stromal cell adipogenic differentiation and secretory activity by renin‐angiotensin system, with an emphasis on AT₂R and its effects. [FEBS J] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Mesoblast Submits Clinical Efficacy And Safety Data to FDA in Rolling Biologics License Application for Remestemcel-L

Mesoblast Limited announced that the FDA has confirmed receipt of Mesoblast’s filing of clinical efficacy and safety data for remestemcel-L in its rolling Biologics License Application for the treatment of children with steroid-refractory acute graft versus host disease. [Mesoblast Limited] Press Release

Longeveron LLC Announces Completion of Enrollment in Phase I Clinical Trial of Longeveron Allogeneic Mesenchymal Stem Cells (LMSCs) in Alzheimer’s Disease

Longeveron LLC announced that it has completed enrollment in its Phase I Alzheimer’s disease trial. This randomized, double-blind, placebo-controlled study is designed to evaluate the safety and efficacy of LMSCs in patients with mild Alzheimer’s disease. [Longeveron LLC (PR Newswire Association LLC.)] Press Release

A Year after the Midterm Elections, Where Are They Now?

November 2018 saw a wave of candidates from all walks of science-engineering, physics, medicine, and other life sciences-win first-time positions in the House, Senate, and state legislatures across the country. Of 20 STEM candidates running for Congressional seats that The Scientist counted last year, 10 won their races, the vast majority of them Democrats as well as political newcomers. [The Scientist] Editorial

From Service to Science: NIH Shifts Focus of Mentoring Network Aimed at Boosting Grantee Diversity

As co-director of graduate affairs at the University of Chicago, Nancy Schwartz spent the past four years helping faculty members at 15 major research universities become better mentors. The project was supported by the National Research Mentoring Network, a $23 million effort that the National Institutes of Health launched after discovering an embarrassing racial gap in who gets NIH grants. [ScienceInsider] Editorial

NEW Transplantation and Cellular Therapy Meetings of ASTCT and CIBMTR
February 19-23, 2020
Orlando, Florida, United States

Visit our events page to see a complete list of events in the community.

NEW Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York)

NEW PhD Positions – Cell Biology (University of Warwick)

NEW Postdoctoral Positions – Cell and Molecular Biology (University of Copenhagen)

NEW PhD Student – Mammalian Development and Disease (Max Planck Institute for Molecular Genetics)

NEW Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota)

Postdoctoral Researcher – Immuno-Oncology (Essen University Hospital)

Research Fellow – Stem Cell Biology & Engineering (New York Blood Center)

Faculty Positions – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Graduate Student Position – Stem Cell Biology (Technion – Israel Institute of Technology)

Postdoctoral Researcher – Proteoglycans in Post-Traumatic Osteoarthritis (Drexel University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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