Mesenchymal Cell News Volume 12.05 | Feb 11 2020

TOP STORY

Bone-Derived Mesenchymal Stem Cells Alleviate Compression-Induced Apoptosis of Nucleus Pulposus Cells by N6 Methyladenosine of Autophagy

Scientists showed that the level of N6 methyladenosine mRNA modifications was decreased, and the autophagic flux was increased in nucleus pulposus cells under compression when they were cocultured with bone-derived MSCs. [Cell Death Dis] Full Article

(Ranked by impact factor of the journal)

IN VITRO

Identification and Comparison of piRNA Expression Profiles of Exosomes Derived from Human Stem Cells from the Apical Papilla and Bone Marrow Mesenchymal Stem Cells

To develop a better understanding of the biological functions of stem cells from the apical papilla (SCAP) and bone marrow MSCs (BMMSCs), researchers compared and analyzed the PIWI-interacting RNA (piRNA) expression profiles of the exosomes derived from human SCAP and the exosomes of BMMSCs. [Stem Cells Dev] Abstract

Differential Regulation of circRNA, miRNA, and piRNA during Early Osteogenic and Chondrogenic Differentiation of Human Mesenchymal Stromal Cells

Investigators identified the differential expression of circular RNA (circRNA), miRNA, and piwi-interacting RNA (piRNA) after lineage commitment towards osteo- and chondrogenesis of human bone marrow MSCs. [Cells] Abstract | Download Full Article

Cycloastragenol as an Exogenous Enhancer of Chondrogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. A Morphological Study

The authors investigated cycloastragenol’s ability to promote cell proliferation, maintain cells in their stable active phenotype, and support the production of cartilaginous extracellular matrix in human adipose-derived MSCs in up to 28 days of three-dimensional chondrogenic culture. [Cells] Abstract | Download Full Article

IN VIVO

CT/NIRF Dual-Modal Imaging Tracking and Therapeutic Efficacy of Transplanted Mesenchymal Stem Cells Labeled with Au Nanoparticles in Silica-Induced Pulmonary Fibrosis

A nanoparticle for computed tomography (CT)/fluorescence dual-modal imaging, Au@Albumin@ICG@PLL, was developed to track bone marrow-derived MSCs that were administered intratracheally into mice with silica-induced pulmonary fibrosis, which facilitated the understanding of the therapeutic effect and the possible molecular mechanism of stem cell therapy. [J Mater Chem B] Abstract

Allo-Antibody Production after Intraarticular Administration of Mesenchymal Stem Cells (MSCs) in an Equine Osteoarthritis Model: Effect of Repeated Administration, MSC Inflammatory Stimulation, and Equine Leukocyte Antigen (ELA) Compatibility

Researchers evaluated the production of cytotoxic allo-antibodies directed against donor’s ELA in mismatched and halfmatched horses receiving repeated intra-articular administration of stimulated MSCs and unstimulated MSCs in pathologic joints. [Stem Cell Res Ther] Full Article

Failure of Intrathecal Allogeneic Mesenchymal Stem Cells to Halt Progressive Demyelination in Two Boys with Cerebral Adrenoleukodystrophy

Investigators delivered MSCs via intrathecal (IT) route to two boys with rapidly advancing cerebral adrenoleukodystrophy. The first boy received three doses one week apart, whereas the second boy received a single dose of IT MSCs. [Stem Cells Transl Med] Full Article

TNF-α and INF-γ Primed Canine Stem Cell-Derived Extracellular Vesicles Alleviate Experimental Murine Colitis

The authors investigated whether extracellular vesicles (EVs) obtained by stimulating inflammatory cytokines on canine adipose MSCs improved anti-inflammatory and/or immunosuppressive potential of EVs, and/or their ability to alleviate inflammation in colitis. [Sci Rep] Full Article

Bone Regeneration of Minipig Mandibular Defect by Adipose Derived Mesenchymal Stem Cells Seeded Tri-Calcium Phosphate- poly(D,L-lactide-co-glycolide) Scaffolds

Researchers assessed the potential of cell-scaffold constructs for the regeneration of extensive mandibular bone defects in a minipig model. [Sci Rep] Full Article

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An Update on Human Periapical Cyst-Mesenchymal Stem Cells and Their Potential Applications in Regenerative Medicine

The authors compare the different types of dental derived MSCs, highlight the isolation technique, the characteristics, and the therapeutic potential of human periapical cyst-MSCs. [Mol Biol Rep] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

BrainStorm Cell Therapeutics and FDA Agree to Potential NurOwn^® Regulatory Pathway for Approval in ALS

BrainStorm Cell Therapeutics, Inc. announced that the company recently held a high level meeting with the FDA to discuss potential NurOwn^® regulatory pathways for approval in ALS. [BrainStorm Cell Therapeutics, Inc.] Press Release

Mesoblast Submits Completed Biologics License Application for Ryoncil™ to US FDA

Mesoblast Limited announced that it has submitted its completed Biologics License Application to the FDA for Ryoncil™, its lead allogeneic cell therapy for the treatment of children with steroid-refractory acute graft versus host disease. [Mesoblast Limited] Press Release

Trump’s 2021 Budget Drowns Science Agencies in Red Ink, Again

It’s another sea of red ink for federal research funding programs in President Donald Trump’s latest budget proposal. The 2021 budget request to Congress released February 10^th calls for deep, often double-digit cuts to R&D spending at major science agencies. [ScienceInsider] Editorial

Major Cancer Institute Sued by Its Own Researchers over ‘Tapering’ Funding

Alleging that a leading cancer funder is slashing their support in an “unethical and reckless” way, six prominent cancer researchers at the University of California, San Diego, have filed a lawsuit to compel it to continue its current level of support. [ScienceInsider] Editorial

NEW First International STEMNET Meeting
May 6-8, 2020
Padua, Italy

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Stem Cell Pluripotency, Reprogramming and Cancer Biology (Cancer Research Center of Lyon)

Senior Research Scientist or Postdoctoral Fellow – Sarcoma Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Research Fellowship – Autism Disease Modeling (Black Family Stem Cell Institute)

Postdoctoral Fellowship – Stem Cell Niche Biology (University of California, San Francisco)

Postdoctoral Fellow – Cardiovascular Research (Temple University)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

Postdoctoral Scholar – Corneal Stem Cells (University of California, Los Angeles)

Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York)

PhD Positions – Cell Biology (University of Warwick)

Postdoctoral Positions – Cell and Molecular Biology (University of Copenhagen)

Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota)

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