Mesenchymal Cell News Volume 12.06 | Feb 18 2020

TOP STORY

EBF1-Deficient Bone Marrow Stroma Elicits Persistent Changes in HSC Potential

Scientists investigated how transcriptional changes in bone marrow MSCs resulted in long-lasting effects on hematopoietic stem cells. Conditional deletion of Ebf1 in these MSCs altered their cellular composition, chromatin structure and gene expression profiles. [Nat Immunol] Abstract

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IN VITRO

Osteogenic Preconditioning in Perfusion Bioreactors Improves Vascularization and Bone Formation by Human Bone Marrow Aspirates

Naïve constructs exhibited robust proangiogenic potential in vitro, while preconditioned scaffolds contained more mesenchymal stem/stromal cells and endothelial cells and exhibited an osteogenic phenotype. [Sci Adv] Full Article

Activation of the PDGFRα-Nrf2 Pathway Mediates Impaired Adipocyte Differentiation in Bone Marrow Mesenchymal Stem Cells Lacking Nck1

Nck1-deficient derived bone marrow mesenchymal stem/stromal cells and C3H10T1/2 mesenchymal stem cells (MSCs) were differentiated into adipocytes in vitro. Genes and proteins expression in these cellular models were determined using qPCR and western blotting respectively. [Cell Commun Signal] Full Article

Long Noncoding RNA FAM83H-AS1 Modulates SpA-Inhibited Osteogenic Differentiation in Human Bone Mesenchymal Stem Cells

Human bone mesenchymal stem cells (hBMSCs) were treated with staphylococcal protein A (SpA) during osteogenic differentiation induction to mimic osteomyelitis in vitro. [Mol Cell Biol] Abstract

Inhibition of PTP1B Phosphorylation Enhances Early Adhesion of Mesenchymal Stem Cells to Facilitate Fabrication of Tissue-Engineered Bone

Upon treatment with the 152RM peptide, researchers observed that the early adhesion of human bone marrow-derived MSCs was accelerated and the anchoring of MSCs on the surface of integrin ligands was enhanced by an enhanced matrix adhesion ability of MSCs themselves. [J Tissue Eng Regen Med] Abstract

The Secretome Derived from Mesenchymal Stromal Cells Cultured in a Xeno-Free Medium Promotes Human Cartilage Recovery In Vitro

The authors investigated the therapeutic potential of conditioned media and extracellular vesicles isolated from human bone marrow stromal cells and grown in a xeno-free culture system compared to the conventional fetal bovine serum-culture system in an in vitro model of osteoarthritis. [Front Bioeng Biotechnol] Full Article

IN VIVO

Deletion of PPARγ in Mesenchymal Lineage Cells Protects against Aging-Induced Cortical Bone Loss in Mice

Investigators showed that mice deficient of peroxisome proliferator-activated receptor gamma (PPARγ) in Dermo1-expressing mesenchymal lineage cells have reduced fat mass and increased cortical bone thickness. [J Gerontol A Biol Sci Med Sci] Abstract

Mesenchymal Stromal Cell Derived CCL2 Is Required for Accelerated Wound Healing

Scientists demonstrated that MSC derived CCL2 was required for MSC induced accelerated wound healing. The role of CCL2 in the interaction between MSCs and macrophages has not been previously demonstrated in accelerated wound healing. [Sci Rep] Full Article

Safety and Efficacy of a Mesenchymal Stem Cell Intramammary Therapy in Dairy Cows with Experimentally Induced Staphylococcus aureus Clinical Mastitis

Intramammary administration of two doses of bovine fetal AT-MSCs in healthy cows did not induce changes in clinical or hematological variables, and gene expression profiles in peripheral blood leukocytes associated to activation and proinflammatory cytokines. [Sci Rep] Full Article

Accelerating Bone Defects Healing in Calvarial Defect Model Using 3D Cultured Bone Marrow-Derived Mesenchymal Stem Cells on Demineralized Bone Particle Scaffold

Researchers evaluated the osteogenic differentiation of bone marrow-derived MSCs on biologically derived gallus gallus domesticus derived demineralized bone particle sponge. [J Tissue Eng Regen Med] Abstract

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Potential Targeted Therapy and Diagnosis Based on Novel Insight into Growth Factors, Receptors, and Downstream Effectors in Acute Kidney Injury and Acute Kidney Injury-Chronic Kidney Disease Progression

Growth factors originating from MSCs via paracrine signaling or extracellular vesicles recruit leukocytes or repair intrinsic cells and may participate in acute kidney injury (AKI) repair or the AKI-chronic kidney disease transition. [Signal Transduct Target Ther] Full Article

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Longeveron LLC Announces Completion of Enrollment in Phase IIb Clinical Trial of Longeveron Allogeneic Mesenchymal Stem Cells (LMSCs) in Aging Frailty

Longeveron LLC announced that it has completed enrollment in its Phase IIb Aging Frailty trial. This double-blinded, randomized, placebo-controlled study is designed to evaluate the safety and efficacy of LMSCs in patients with mild to moderate frailty. [Longeveron LLC] Press Release

US FDA Grants Orphan Drug Designation for Retrotope’s RT001 in the Treatment of Progressive SupraNuclear Palsy (PSP)

Retrotope, Inc. announced that the FDA Office of Orphan Products Development granted orphan drug designation for its chemically-modified polyunsaturated fatty acid drug (RT001) for the treatment of Progressive SupraNuclear Palsy (PSP). [Retrotope, Inc.] Press Release

‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide

Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19—and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial

Harvard, Yale Investigated for Undisclosed Foreign Funding

The US Department of Education is investigating Harvard and Yale Universities for allegedly failing to disclose funds from other nations, according to a statement released February 12. First reported by the Wall Street Journal on Wednesday, the investigations are the latest in a series of efforts by the department to crack down on foreign influence in US institutions. [The Scientist] Editorial

NEW International Society for Stem Cell Research (ISSCR)
June 24-27, 2020
Boston, Massachusetts, United States

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NEW Postdoctoral Scholar – Cancer Research in Sarcoma (The Ohio State University)

Postdoctoral Position – Stem Cell Pluripotency, Reprogramming and Cancer Biology (Cancer Research Center of Lyon)

Senior Research Scientist or Postdoctoral Fellow – Sarcoma Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Research Fellowship – Autism Disease Modeling (Black Family Stem Cell Institute)

Postdoctoral Fellowship – Stem Cell Niche Biology (University of California, San Francisco)

Postdoctoral Fellow – Cardiovascular Research (Temple University)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

Postdoctoral Scholar – Corneal Stem Cells (University of California, Los Angeles)

Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York)

PhD Positions – Cell Biology (University of Warwick)

Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota)

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