Mesenchymal Cell News 12.06 February 18, 2020 | |
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TOP STORYEBF1-Deficient Bone Marrow Stroma Elicits Persistent Changes in HSC Potential Scientists investigated how transcriptional changes in bone marrow MSCs resulted in long-lasting effects on hematopoietic stem cells. Conditional deletion of Ebf1 in these MSCs altered their cellular composition, chromatin structure and gene expression profiles. [Nat Immunol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITRONaïve constructs exhibited robust proangiogenic potential in vitro, while preconditioned scaffolds contained more mesenchymal stem/stromal cells and endothelial cells and exhibited an osteogenic phenotype. [Sci Adv] Full Article Nck1-deficient derived bone marrow mesenchymal stem/stromal cells and C3H10T1/2 mesenchymal stem cells (MSCs) were differentiated into adipocytes in vitro. Genes and proteins expression in these cellular models were determined using qPCR and western blotting respectively. [Cell Commun Signal] Full Article Human bone mesenchymal stem cells (hBMSCs) were treated with staphylococcal protein A (SpA) during osteogenic differentiation induction to mimic osteomyelitis in vitro. [Mol Cell Biol] Abstract Upon treatment with the 152RM peptide, researchers observed that the early adhesion of human bone marrow-derived MSCs was accelerated and the anchoring of MSCs on the surface of integrin ligands was enhanced by an enhanced matrix adhesion ability of MSCs themselves. [J Tissue Eng Regen Med] Abstract The authors investigated the therapeutic potential of conditioned media and extracellular vesicles isolated from human bone marrow stromal cells and grown in a xeno-free culture system compared to the conventional fetal bovine serum-culture system in an in vitro model of osteoarthritis. [Front Bioeng Biotechnol] Full Article IN VIVOInvestigators showed that mice deficient of peroxisome proliferator-activated receptor gamma (PPARγ) in Dermo1-expressing mesenchymal lineage cells have reduced fat mass and increased cortical bone thickness. [J Gerontol A Biol Sci Med Sci] Abstract Mesenchymal Stromal Cell Derived CCL2 Is Required for Accelerated Wound Healing Scientists demonstrated that MSC derived CCL2 was required for MSC induced accelerated wound healing. The role of CCL2 in the interaction between MSCs and macrophages has not been previously demonstrated in accelerated wound healing. [Sci Rep] Full Article Intramammary administration of two doses of bovine fetal AT-MSCs in healthy cows did not induce changes in clinical or hematological variables, and gene expression profiles in peripheral blood leukocytes associated to activation and proinflammatory cytokines. [Sci Rep] Full Article Researchers evaluated the osteogenic differentiation of bone marrow-derived MSCs on biologically derived gallus gallus domesticus derived demineralized bone particle sponge. [J Tissue Eng Regen Med] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSGrowth factors originating from MSCs via paracrine signaling or extracellular vesicles recruit leukocytes or repair intrinsic cells and may participate in acute kidney injury (AKI) repair or the AKI-chronic kidney disease transition. [Signal Transduct Target Ther] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSLongeveron LLC announced that it has completed enrollment in its Phase IIb Aging Frailty trial. This double-blinded, randomized, placebo-controlled study is designed to evaluate the safety and efficacy of LMSCs in patients with mild to moderate frailty. [Longeveron LLC] Press Release Retrotope, Inc. announced that the FDA Office of Orphan Products Development granted orphan drug designation for its chemically-modified polyunsaturated fatty acid drug (RT001) for the treatment of Progressive SupraNuclear Palsy (PSP). [Retrotope, Inc.] Press Release | |
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POLICY NEWS‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19—and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial Harvard, Yale Investigated for Undisclosed Foreign Funding The US Department of Education is investigating Harvard and Yale Universities for allegedly failing to disclose funds from other nations, according to a statement released February 12. First reported by the Wall Street Journal on Wednesday, the investigations are the latest in a series of efforts by the department to crack down on foreign influence in US institutions. [The Scientist] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholar – Cancer Research in Sarcoma (The Ohio State University) Postdoctoral Research Fellowship – Autism Disease Modeling (Black Family Stem Cell Institute) Postdoctoral Fellowship – Stem Cell Niche Biology (University of California, San Francisco) Postdoctoral Fellow – Cardiovascular Research (Temple University) Postdoctoral Associate – Cartilage Regeneration (Drexel University) Postdoctoral Scholar – Corneal Stem Cells (University of California, Los Angeles) Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York) PhD Positions – Cell Biology (University of Warwick) Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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