Mesenchymal Cell News Volume 12.14 | Apr 21 2020

TOP STORY

Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS: A Controlled Experimental Study in Sheep

The administration of human MSCs (hMSCs) did not improve oxygenation or pulmonary function. However, histological evidence of lung injury and BAL IL-8 were reduced. hMSC treated animals had a significantly lower cumulative requirement for vasopressor. [Am J Respir Crit Care Med] Abstract

(Ranked by impact factor of the journal)

IN VITRO

MSC-Induced lncRNA HCP5 Drove Fatty Acid Oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB Axis to Promote Stemness and Chemo-Resistance of Gastric Cancer

Scientists revealed that MSC co-culture improved stemness and drug-resistance of gastric cancer cells. [Cell Death Dis] Full Article

Differentiation of Adipose-Derived Stem Cells into Functional Chondrocytes by a Small Molecule that Induces Sox9

Ellipticine induced adipose-derived stem cells to differentiate into mature chondrocytes without hypertrophic chondrocytes in vitro and in vivo. [Exp Mol Med] Full Article

HSD11B1 Is Upregulated Synergistically by IFNγ and TNFα and Mediates TSG-6 Expression in Human UC-MSCs

Researchers found that glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to the active cortisol and thereby regulates tissue glucocorticoid levels, was greatly upregulated by IFNγ and TNFα in human umbilical cord-derived MSCs in a synergistic manner. [Cell Death Discov] Full Article

Leptin Acts on Mesenchymal Stem Cells to Promote Chemoresistance in Osteosarcoma Cells

Using cell viability and apoptosis assays, investigators showed that medium conditioned by leptin-treated human MSCs promoted cisplatin resistance in cultured human osteosarcoma cells. [Aging (Albany NY)] Full Article

Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional In Vitro Bone Model

The authors investigated and optimized 3D culture conditions for macrophages, and then co-cultured macrophages with MSCs which were induced to undergo osteogenic differentiation to examine the effect of macrophages on new bone formation. [Tissue Eng Part A] Abstract

Tenocyte-Imprinted Substrate: A Topography-Based Inducer for Tenogenic Differentiation in Adipose Tissue-Derived Mesenchymal Stem Cells

The tenogenic differentiation induction capacity of the tenocyte replica in adipose tissue-derived MSCs was investigated and compared with other groups, including tissue replica, decellularized tendon, and bone morphogenic protein-12, as other potential inducers. [Biomed Mater] Full Article

IN VIVO

Glutathione Dynamics Determine the Therapeutic Efficacy of Mesenchymal Stem Cells for Graft-versus-Host Disease via CREB1-NRF2 Pathway

Administration of MSCs overexpressing CREB1-NRF2 target genes alleviated graft-versus-host disease (GVHD) in a humanized mouse model, resulting in improved survival, decreased weight loss, and reduced histopathologic damages in GVHD target organs. [Sci Adv] Full Article

MSCs Ameliorate Hepatocellular Apoptosis Mediated by PINK1-Dependent Mitophagy in Liver Ischemia/Reperfusion Injury through AMPKα Activation

Scientists investigated the effect and potential mechanism of MSCs against liver ischemia/reperfusion (I/R) injury. Effects of MSCs were studied in mice liver I/R injury model and in a hypoxia/reoxygenation model of L02 hepatocytes. [Cell Death Dis] Full Article

Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

Investigators showed that leukocytes and specifically polymorphonuclear neutrophils contributed to MSC-small extracellular vesicle-induced ischemic neuroprotection [Stroke] Abstract | Graphical Abstract

Platelet-Rich Plasma Enhances the Repair Capacity of Muscle-Derived Mesenchymal Stem Cells to Large Humeral Bone Defect in Rabbits

Platelet-rich plasma application significantly enhanced the regeneration capacity of muscle-derived MSCs (M-MSCs) in a large bone defect via promoting the migration and proliferation of M-MSCs, and also inducing the osteogenic differentiation. [Sci Rep] Full Article

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Mesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing: Lessons from the Physiology of Matrix and Hypoxia Support

The authors provide an overview of cutaneous wound healing with discussion on how extracellular matrix proteins and hypoxia can be utilized to improve MSC retention and therapeutic outcome. [Am J Pathol] Abstract

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

First COVID-19 Patient Treated under Emergency Use IND at Providence Saint John’s Health Center Using Stemedica Ischemia-Tolerant Allogeneic Mesenchymal Bone Marrow Cells

A single patient, emergency Investigational New Drug (IND) use was cleared by the FDA for the treatment of severe lung injury due to COVID-19 at the Providence Saint John’s Health Center, Santa Monica, CA with intravenous administration of ischemia-tolerant allogeneic mesenchymal bone marrow cells manufactured by Stemedica Cell Technologies, Inc. [Stemedica Cell Technologies, Inc.] Press Release

Queen’s University Leading Cell Therapy Clinical Trial to Help Improve Outcomes in COVID-19 Patients

Researchers at Queen’s University Belfast are leading a UK-wide clinical trial, offering an innovative cell therapy treatment for COVID-19 patients with acute respiratory failure. [Queen’s University Belfast] Press Release

Wize Pharma’s Strategic Transaction Partner Bonus Biogroup Initiates Preclinical Study for Treatment of Respiratory Distress in COVID-19 Patients

Wize Pharma, Inc. has initiated a preclinical study of its drug product candidate MesenCure, specifically developed to potentially treat acute and life-threatening respiratory distress and pneumonia whether as a result of infection with coronavirus (COVID-19), or any other type of virus, bacterial infection, or exposure to other contaminants. [Wize Pharma, Inc. (PR Newswire Association LLC.)] Press Release

Predictive Submits Emergency Use Authorization Application for Treatment of Acute Respiratory Distress Syndrome Secondary to COVID-19 with Umbilical Cord Mesenchymal Stem Cells

Predictive Biotech announced that it submitted an Emergency Use Authorization application with the FDA for the immediate use of MSCs derived from umbilical cord tissue for the treatment of acute respiratory distress syndrome, secondary to SARS-CoV-2, coronavirus disease 2019 (COVID-19). [Predictive Biotech] Press Release

Creative Medical Technology Holdings Is Granted Patent on Mesenchymal Stem Cells for Female Infertility Pending Quayle Action

Creative Medical Technology Holdings Inc. announced receipt of a Quayle Action on its patent application #15/652213 entitled Methods for Treatment of Premature Ovarian Failure and Ovarian Aging using Regenerative Cells. [Creative Medical Technology Holdings Inc. (PR Newswire Association LLC.)] Press Release

How Research Funders Are Tackling Coronavirus Disruption

While science is crucial to the fight against COVID-19, researchers confined to their homes and unable to carry on with grant-funded work are becoming increasingly concerned about how the coronavirus pandemic will affect their funding. [Nature News] Editorial

‘Short-Sighted.’ Health Experts Decry Trump’s Freeze on US Funding for WHO as World Fights Pandemic

President Donald Trump said he will suspend US funding to the World Health Organization (WHO) pending a 60- to 90-day investigation into how the agency has handled the response to the COVID-19 pandemic. [ScienceInsider] Editorial

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NEW Principal Investigators and Postdoctoral Fellows – Cell Biology (Fudan University)

Senior Research Scientist – Regenerative Medicine (NYU Grossman School of Medicine)

Principal Investigator/Professor Positions – Stem Cell Research (Guangzhou Institutes of Biomedicine and Health)

PhD Student – Bioprinting of Tissues (Uppsala University)

Postdoctoral Positions – Systems Biology and Metabolism (Charité – Universitätsmedizin Berlin)

Postdoctoral Fellow – Biomaterials and Nanotechnology in Regenerative Medicine (Guangzhou Medical University)

Assistant Professor – Sarcoma (McGill University)

Professor – Molecular Physiology (Karolinska Institutet)

Faculty Position – Regenerative Medicine (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)

Postdoctoral Fellowship – Bone Repair (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Osteoarthritis, Mechanobiology, and Regenerative Medicine (Oklahoma Medical Research Foundation)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

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