Pancreatic Cell News Volume 11.06 | Feb 18 2020

TOP STORY

GLP-1 Receptor Agonists Synergize with DYRK1A Inhibitors to Potentiate Functional Human β Cell Regeneration

Glucagon-like peptide-1 receptor (GLP1R) agonist-dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor synergy required combined inhibition of DYRK1A and an increase in cAMP and did not lead to β cell dedifferentiation. [Sci Transl Med] Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

Scientists showed that fast ultradian oscillations of the ligand Dll1 and the transcriptional effector Hes1 were crucial for MPC expansion, and changes in Hes1 oscillation parameters were associated with selective adoption of bipotent progenitor or unipotent pro-acinar cell fate. [Dev Cell] Full Article | Graphical Abstract

Regulation of Integrin α6A by Lactogenic Hormones in Rat Pancreatic β-Cells: Implications for the Physiological Adaptation to Pregnancy

Quantitative RT-PCR was used to evaluate the expression of several integrins and laminins in isolated neonatal rat islets in response to growth hormone and prolactin treatment. [Acta Physiol (Oxf)] Abstract

Wolfram Syndrome 1 Gene Regulates Pathways Maintaining Beta-Cell Health and Survival

Depletion of Wolfram syndrome 1 in vivo and in vitro caused functional defects in glucose-stimulated insulin secretion and insulin content, triggering Chop-mediated apoptotic pathways. [Lab Invest] Abstract

Comprehensive Detection of Single Amino Acid Variants and Evaluation of Their Deleterious Potential in a PANC-1 Cell Line

Investigators report an expanded detection of single amino acid variants (SAAVs) in the PANC-1 cell line using three different strategies, which resulted in identification of 540 SAAVs in mass spectrometry data. [J Proteome Res] Abstract

Intra-Islet GLP-1, but Not CCK, Is Necessary for β-Cell Function in Mouse and Human Islets

Investigators tested whether islet-derived glucagon-like peptide 1 (GLP-1) or cholecystokinin (CCK) was necessary for the full stimulation of insulin secretion. [Sci Rep] Full Article

The Intermediate Proteasome Is Constitutively Expressed in Pancreatic Beta Cells and Upregulated by Stimulatory, Low Concentrations of Interleukin 1 β

The authors investigated whether so-called inducible subunits of the proteasome were constitutively expressed in β cells, regulated by inflammatory signals and participated in the formation of active intermediate or immuno-proteasomes. [PLoS One] Full Article

SNAP23 Depletion Enables More SNAP25/Calcium Channel Excitosome Formation to Increase Insulin Exocytosis in Type 2 Diabetes

Researchers showed that SNAP23, when depleted in mouse β cells in vivo and human β cells in vitro, paradoxically increased biphasic glucose-stimulated insulin secretion corresponding to increased exocytosis of predocked and newcomer insulin granules. [JCI Insight] Full Article

PANCREATIC CANCER

O-GlcNAcylation of PFKFB3 Is Required for Tumor Cell Proliferation under Hypoxia

Scientists showed that the glycolytic regulator 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3), which also promoted cell cycle progression in the nucleus, was O-GlcNAcylated in response to hypoxia. [Oncogenesis] Full Article

Integrative Proteomic and Functional Analyses Provide Novel Insights into the Action of the Repurposed Drug Candidate Nitroxoline in AsPC-1 Cells

Using shotgun proteomics researchers identified 363 proteins affected by nitroxoline treatment in AsPC-1 pancreatic cancer cells, including 81 consistently deregulated at both 24- and 48-hour treatment. [Sci Rep] Full Article

Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News.

Mitochondrial Ion Channels in Pancreatic β-Cells: Novel Pharmacological Targets for the Treatment of Type 2 Diabetes

The authors describe the mitochondrial ion channels identified in pancreatic β-cells, and further discuss the possibility of targeting specific β-cell mitochondrial channels for the treatment of Type 2 diabetes. [Br J Pharmacol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

JDRF Reaches New Milestones in Work to Drive Cures for Type 1 Diabetes and Improve Lives

JDRF funded $121.5 million directly and helped generate more than $400 million in total type 1 diabetes research funds from nonprofits, government, and industry to propel a year of remarkable breakthroughs in 2019. [JDRF] Press Release

TriSalus Life Sciences and Roger Williams Medical Center Announce Initiation of Phase I Clinical Trial for a Novel Delivery Technology That Can Enhance Drug Delivery into Pancreatic Tumors

TriSalus Life Sciences announced the initiation of a new clinical trial assessing the safety and feasibility of an innovative new treatment that combines its intravascular, tumor-directed proprietary Pressure-Enabled Drug Delivery^™ approach with standard of care systemic chemotherapy. [TriSalus Life Sciences (BusinessWire, Inc.)] Press Release

‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide

Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19—and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial

Harvard, Yale Investigated for Undisclosed Foreign Funding

The US Department of Education is investigating Harvard and Yale Universities for allegedly failing to disclose funds from other nations, according to a statement released February 12. First reported by the Wall Street Journal on Wednesday, the investigations are the latest in a series of efforts by the department to crack down on foreign influence in US institutions. [The Scientist] Editorial

NEW International Society for Stem Cell Research (ISSCR)
June 24-27, 2020
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center)

NEW Postdoctoral Fellow – Therapeutics in Pancreatic Cancer (The University of Tennessee Health Science Center)

NEW Postdoctoral Associate – Pancreatic Cancer Biology Research (University of Miami Health System)

Postdoctoral Studentship – Diabetes Epidemiology (Imperial College London)

Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center)

Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory)

Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health)

Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center)

Postdoctoral Research Fellow – Novel Drivers of Pancreatic Cancer (H. Lee Moffitt Cancer Center & Research Institute)

Postdoctoral Fellow – Elevated Androgen in Type 2 Diabetes (Temple University)

Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Postdoctoral Fellowship – Regenerative Medicine and Metabolic Biology (Indiana Biosciences Research Institute)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Pancreatic Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.