Pancreatic Cell News Volume 11.08 | Mar 03 2020

TOP STORY

CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma

Scientists report that sequential administration of CDK4/6 inhibitors after taxanes cooperated to prevent cellular proliferation in pancreatic ductal adenocarcinoma cells, patient-derived xenografts, and genetically engineered mice with Kras G12V and Cdkn2-null mutations. [Cancer Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

The RB Gene Family Controls the Maturation State of the EndoC-βH2 Human Pancreatic β-Cells

In EndoC-βH2 cells, the knock-down of RB itself, and, to a lesser extent, of its relative P130, precluded most events triggered by SV40LT depletion. [Differentiation] Abstract

PANCREATIC CANCER

Targeting Cancer-Associated Fibroblasts by Dual-Responsive Lipid-Albumin Nanoparticles to Enhance Drug Perfusion for Pancreatic Tumor Therapy

Considering the special tumor microenvironment of pancreatic ductal adenocarcinoma, researchers constructed a novel nanoparticle which was responsive to the membrane biomarker FAP-α on cancer-associated fibroblasts and near-infrared laser irradiation. [J Control Release] Abstract | Graphical Abstract

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

Investigators showed that in KRAS-driven murine pancreatic ductal adenocarcinoma cells, loss of Pten strongly enhanced both mTOR signaling and macropinocytosis. [Cell Rep] Full Article | Graphical Abstract

MUC1 Oncoprotein Mitigates ER Stress via CDA-Mediated Reprogramming of Pyrimidine Metabolism

MUC1 knockdown in pancreatic cancer cells enhanced unfolded protein response signaling and cell death upon ER stress induction. Transcriptomic analysis revealed alterations in the pyrimidine metabolic pathway and cytidine deaminase. [Oncogene] Abstract

Dysbindin Promotes Pancreatic Ductal Adenocarcinoma Metastasis by Activating NF-κB/MDM2 via miR-342-3p

Increased dysbindin levels correlated with aggressive features in pancreatic ductal adenocarcinoma (PDAC), and the overexpression of dysbindin significantly promoted PDAC metastasis and invasion in vitro and in vivo. [Cancer Lett] Abstract

Ectopic HOTTIP Expression Induces Noncanonical Transactivation Pathways to Promote Growth and Invasiveness in Pancreatic Ductal Adenocarcinoma

Scientists indicated the importance of the noncanonical trans-acting HOTTIP-WDR5-MLL1 pathway in the HOTTIP regulatory mechanism by promoting oncogenic protein expression. [Cancer Lett] Abstract

PROM2 Promotes Gemcitabine Chemoresistance via Activating the Akt Signaling Pathway in Pancreatic Cancer

The authors showed that PROM2, a transmembrane glycoprotein, was ubiquitously upregulated in pancreatic cancer cells. They found that higher PROM2 expression was associated with shortened overall and disease-free survival times in patients diagnosed with pancreatic cancer. [Exp Mol Med] Full Article

Modification of Radiosensitivity by Curcumin in Human Pancreatic Cancer Cell Lines

Researchers evaluated the impact of curcumin on the radiosensitivity of the established human pancreatic cancer cell lines Panc-1 and MiaPaCa-2 in vitro. [Sci Rep] Full Article

Long Noncoding RNA LINC00657 Enhances the Malignancy of Pancreatic Ductal Adenocarcinoma by Acting as a Competing Endogenous RNA on MicroRNA-433 to Increase PAK4 Expression

The effects of LINC00657 upregulation on pancreatic ductal adenocarcinoma cell proliferation, apoptosis, migration, and invasion in vitro and tumor growth in vivo were explored using CCK-8, flow cytometry, Transwell migration and invasion assays, and a xenograft tumor formation experiment. [Cell Cycle] Abstract

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Insights Into Pancreatic Islet Cell Dysfunction from Type 2 Diabetes Mellitus Genetics

The authors examine current human models that are used to study both β-cell development and function, including EndoC-β cell lines and human induced pluripotent stem cell-derived β-like cells. [Nat Rev Endocrinol] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

MPM Capital Announces $100M Oncology Innovations Fund as Part of Novel Venture Philanthropy Collaboration with Dana-Farber Cancer Institute

MPM Capital and Dana-Farber Cancer Institute have entered into a unique, first-of-its-kind, impact investing collaboration. The initiative partners fundraising for biotech venture capital investing with philanthropic fundraising for cancer research. [MPM Capital (BusinessWire, Inc.)] Press Release

Tandem Diabetes Care Announces FDA Designation of Basal-IQ Technology as an Interoperable Automated Glycemic Controller

Tandem Diabetes Care, Inc. announced FDA clearance of its Basal-IQ^™ technology as an interoperable automated glycemic controller. [Tandem Diabetes Care, Inc. (BusinessWire, Inc.)] Press Release

China Bans Cash Rewards for Publishing Papers

Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial

UC Santa Cruz Fires Graduate Students Taking Part in Strike

The University of California, Santa Cruz, fired 54 graduate student employees from their teaching positions on February 28, in the latest escalation of a months-long dispute over student pay, the Santa Cruz Sentinel reports. [The Scientist] Editorial

NEW AACR Special Conference on Pancreatic Cancer
September 29-October 2, 2020
Philadelphia, Pennsylvania, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowships – Pancreatic Disease (University of Copenhagen)

Senior Scientist – Diabetes (International Institute of Innovation and Technology)

Investigator Group Leader – Metabolic Research in Diabetes (German Research Center for Environmental Health)

Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Therapeutics in Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Associate – Pancreatic Cancer Biology Research (University of Miami Health System)

Postdoctoral Studentship – Diabetes Epidemiology (Imperial College London)

Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Diabetes (Harvard Joslin Diabetes Center)

Postdoctoral Associate – RNA Cancer Biology and Diabetes (The Jackson Laboratory)

Postdoctoral Fellowship – Diabetes and Kidney Diseases (National Institutes of Health)

Postdoctoral Research Fellow – Endocrinology and Diabetes (Cedars-Sinai Medical Center)

Postdoctoral Associate Position – Proteomics and Immunoproteomics in Diabetes (Cornell University)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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