Pancreatic Cell News Volume 11.12 | Mar 31 2020

TOP STORY

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Scientists showed that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling suppressed pancreatic ductal adenocarcinoma proliferation through induction of retinoblastoma protein-mediated senescence. [Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

DIABETES & PANCREATITIS

Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes

Researchers report that modulating the unfolded protein response (UPR) in β cells of non-obese diabetic mice by deleting the UPR sensor IRE1α prior to insulitis induced a transient dedifferentiation of β cells, resulting in substantially reduced islet immune cell infiltration and β cell apoptosis. [Cell Metab] Abstract | Graphical Abstract

Synthesis and In Vivo Behavior of an Exendin-4-Based MRI Probe Capable of β-Cell-Dependent Contrast Enhancement in the Pancreas

Compared to the ubiquitous probe, exendin-4-dota(ga)-Gd(III) complex showed selective uptake by the pancreas with a marked decrease in accumulation observed after the loss of β-cells elicited by deleting the microRNA processing enzyme, DICER. [Dalton Trans] Abstract

Deletion of Gpr27 In Vivo Reduces Insulin mRNA but Does Not Result in Diabetes

Insulin and Pdx1 mRNA in Gpr27 knockout islets were reduced by 30%, but this did not translate to a reduction in islet insulin content or beta cell mass. [Sci Rep] Full Article

PANCREATIC CANCER

CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA Binding Proteins and Sponging miR-942

Using circRNA sequencing, scientists identified 169 differentially expressed circRNA in pancreatic ductal adenocarcinoma cells compared to non-tumor human pancreatic ductal epithelial cells. [Cancer Res] Abstract

Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

Researchers used mass-spectrometry-based quantitative temporal proteomics to profile the proteomic response to KRAS inhibitors in pancreatic and lung cancer 2D and 3D cellular models. [Cell Rep] Full Article | Graphical Abstract

Hexosamine Pathway Inhibition Overcomes Pancreatic Cancer Resistance to Gemcitabine through Unfolded Protein Response and EGFR-Akt Pathway Modulation

Investigators showed that enhancement of the hexosamine biosynthetic pathway, through the upregulation of the enzyme phosphoacetylglucosamine mutase 3, was associated with the onset of gemcitabine resistance in pancreatic cancer. [Oncogene] Abstract

Hyperthermia Affects Collagen Fiber Architecture and Induces Apoptosis in Pancreatic and Fibroblast Tumor Hetero-Spheroids In Vitro

Researchers studied the effect of mild hyperthermia on fibrillary collagen architecture in murine Achilles tendons and in a pancreatic cancer model, in vitro, i.e. 3D hetero-type tumor spheroids, consisting of pancreatic cancer cells and fibroblasts, producing collagen fibers. [Nanomedicine] Abstract | Graphical Abstract | Full Article

Overexpression of YBX1 Promotes Pancreatic Ductal Adenocarcinoma Growth via the GSK3B/Cyclin D1/Cyclin E1 Pathway

In pancreatic ductal adenocarcinoma cell lines, Y-box binding protein 1 (YBX1) regulated cell cycle progression, proliferation, and the expression of glycogen synthase kinase 3 beta (GSK3B) and cell cycle-related proteins cyclin D1 and E1. [Mol Ther Oncolytics] Abstract

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Pancreatic Adenocarcinoma: Unconventional Approaches for an Unconventional Disease

The authors review current treatments, limitations, and pitfalls in the management of pancreatic cancer and discusses current research in novel targets and drug development to overcome these clinical challenges. [Cancer Res] Abstract

Visit our reviews page to see a complete list of reviews in the pancreatic cell research field.

Myriad Seeks Japanese Regulatory Approval for Its BRACAnalysis^® Diagnostic System in People with Advanced Pancreatic and Prostate Cancer

Myriad Genetics, Inc. announced it has submitted a supplementary application with the Japanese Ministry of Health Labour and Welfare for its BRACAnalysis^® Diagnostic System to be used as a companion diagnostic to help to identify people with metastatic pancreatic or metastatic castration-resistant prostate cancer who have germline BRCA1 and BRCA2 mutations. [Myriad Genetics, Inc.] Press Release

Congressional Relief Package Extends Special Diabetes Program and Provides Additional Support for T1D Community

In response to the COVID-19 pandemic and its impact around the world, JDRF is working to ensure the 1.6 million Americans living with T1D stay informed and healthy during this challenging time. These efforts include continued advocacy to address the near- and long-term needs of the T1D community. [JDRF, Inc.] Press Release

Cull, Release or Bring Them Home: Coronavirus Crisis Forces Hard Decisions for Labs with Animals

As universities scale back operations and scientists observe stay-at-home orders, many are struggling to protect their research and the animals that power it. [Nature News] Editorial

Tens of Thousands of Scientists Are Redeploying to Fight Coronavirus

As labs shut down around the world, researchers are finding creative ways to donate their time, supplies and expertise. [Nature News] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

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NEW Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech)

NEW Postdoctoral Student – RNA-Dependent Proteins in Cancer Cell Mitosis (German Cancer Research Center in the Helmholtz Association)

Postdoctoral Research Position – Cancer Therapeutics (NIH National Cancer Institute)

Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University)

Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine)

Senior Scientist – Diabetes (International Institute of Innovation and Technology)

Investigator Group Leader – Metabolic Research in Diabetes (German Research Center for Environmental Health)

Postdoctoral Fellow – Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Therapeutics in Pancreatic Cancer (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Cancer Biology (Memorial Sloan Kettering Cancer Center)

Postdoctoral Researcher – Endocrinology, Diabetes, and Metabolism (The University of Alabama at Birmingham)

Research Positions – Pancreatic Beta-Cells (Université de Montréal)

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