Pancreatic Cell News 11.15 April 21, 2020 | |
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TOP STORYEndocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma Researchers identified aberrant beta cell expression of the peptide hormone cholecystokinin (Cck) in response to obesity and showed that islet Cck promoted oncogenic Kras-driven pancreatic ductal tumorigenesis. [Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITISPatch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes An analysis of function and gene expression networks identified a gene set associated with functional heterogeneity in β cells that could be used to predict electrophysiology. [Cell Metab] Abstract | Graphical Abstract Paracrine Control of α-Cell Glucagon Exocytosis Is Compromised in Human Type-2 Diabetes Investigators report that exocytosis was moderately reduced in α-cells of type-2 diabetes donors, without changes in voltage-dependent ion currents or granule trafficking. [Nat Commun] Full Article Compared to islets cultured on tissue culture plastic, islets cultured on 3D-extracellular matrix exhibited greater attachment, higher survival rate, increased insulin content, and enhanced glucose-stimulated insulin secretion. [FASEB J] Abstract β-Cells Operate Collectively to Help Maintain Glucose Homeostasis The authors suggest how the conservation of entire cell-cell conductance, observed in coupled but not uncoupled β-cells, emerged as a collective phenomenon. [Biophys J] Abstract Pancreatic acinar cells were stimulated with cholecystokinin-8 in vitro. Acute pancreatitis was induced by intraperitoneal injections of caerulein and LPS or L-arginine. Pancreatitis severity was assessed biochemically and histologically. [Am J Physiol Gastrointest Liver Physiol] Abstract PANCREATIC CANCERThe authors investigated the biological effects of specific MIF inhibitor, ISO-1, on the proliferation, migration and invasion of PANC-1 human pancreatic cells in vitro, and on tumor growth in a xenograft tumor model in vivo. [Sci Rep] Full Article Alogliptin did not attenuate tumor cytotoxicity of oxaliplatin in cultured colon, gastric, or pancreatic cancer cell lines and tumor-bearing mice. [Sci Rep] Full Article Researchers confirmed that PD-L1 was overexpressed in pancreatic ductal adenocarcinoma (PDAC) samples from two independent cohorts of patients with radical resection. Cancer Forkhead box protein 3 (C-FOXP3) was colocalized and correlated with the expression of PD-L1 in tumor cells at the mRNA and protein levels. [Signal Transduct Target Ther] Full Article Subscribe to one of our other 19 science newsletters such as Hepatic Cell News & Intestinal Cell News. | |
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REVIEWSNew Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma Major efforts are underway to effectively target the tumor microenvironment and to integrate immunotherapy into the treatment of pancreatic ductal adenocarcinoma. [Drugs] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSFirst Patient Treated with Leronlimab in Phase IIb/III Trial for COVID-19 CytoDyn, Inc. announced it has treated the first patient in its Phase II basket trial for 22 solid cancer tumors. [CytoDyn, Inc.] Press Release Hutchison China MediTech Limited announced that FDA has granted two Fast Track Designations for the development of surufatinib, for the treatment of both advanced and progressive pancreatic neuroendocrine tumors (NET) and extra-pancreatic NET in patients who are not amenable for surgery. [Chi-Med, Inc.] Press Release | |
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POLICY NEWSUntapped Potential: More US Labs Could Be Providing Tests for Coronavirus A survey of more than 4,000 researchers in the United States suggests that better coordination at an institutional and national level could make hundreds of thousands more tests for coronavirus available. [Nature News] Editorial Director of US Agency Key to Vaccine Development Leaves Role Suddenly Amid Coronavirus Pandemic Rick Bright, one of the nation’s leading vaccine development experts and the director of the Biomedical Advanced Research and Development Authority, is no longer leading the organization. [STAT News] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Studentship – Cancer Biology Research (Danish Cancer Society Research Center) PhD Research Scientist – Beta Cells in Diet-Induced Diabetes (Medical University of Vienna) Laboratory Manager – Diabetes (Helmholtz Zentrum München) Postdoctoral Research Fellow – Inflammatory Cell Death (Genentech) Postdoctoral Research Position – Cancer Therapeutics (NIH National Cancer Institute) Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University) Postdoctoral Research Fellow – Pancreatic Beta Cells (Washington University School of Medicine) Senior Scientist – Diabetes (International Institute of Innovation and Technology) Research Positions – Pancreatic Beta-Cells (Université de Montréal) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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