Pulmonary Cell News Volume 8.47 | Dec 5 2019

TOP STORY

Epithelial Tumor Suppressor ELF3 Is a Lineage-Specific Amplified Oncogene in Lung Adenocarcinoma

The authors showed that E74 like ETS transcription factor 3 (ELF3) was an oncogene in the adenocarcinoma subtype of lung cancer, providing genetic, functional, and clinical evidence of subtype specificity. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

WNT/RYK Signaling Restricts Goblet Cell Differentiation during Lung Development and Repair

RYK functioned as a WNT coreceptor, and, in the developing lung, scientists observed a high RYK expression in airway epithelial cells and moderate expression in mesenchymal cells as well as in alveolar epithelial cells. [Proc Natl Acad Sci USA] Full Article

Lipid Nanoparticles Biocompatibility and Cellular Uptake in a 3D Human Lung Model

Nanostructured lipid carriers (NLC) and mannosylated-NLCs were synthetized and characterized. Their uptake and biocompatibility were tested in a 3D human lung model. [Nanomedicine (Lond)] Full Article

Altered Generation of Ciliated Cells in Chronic Obstructive Pulmonary Disease

COPD epithelium in large airways, when compared to controls, showed decreased β-tubulin IV⁺ ciliated cells and increased MUC5AC⁺ goblet cells. Both features were recapitulated in the air-liquid interface-cultured epithelium from COPD patients. [Sci Rep] Full Article

FOXO3a Regulates Rhinovirus-Induced Innate Immune Responses in Airway Epithelial Cells

Researchers showed that forkhead transcription factor class O (FOXO)3a played a critical role in regulating antiviral responses as well as limiting pro-inflammatory cytokine expression. [Sci Rep] Full Article

LUNG CANCER

A High-Throughput Screen Identifies That CDK7 Activates Glucose Consumption in Lung Cancer Cells

Scientists identified milciclib that blocked glucose consumption in H460 and H1975, but not in HCC827 or A549 cells, by decreasing SLC2A1 mRNA and protein levels and by inhibiting glucose transport. [Nat Commun] Full Article

Inhibition of Lung Cancer Growth and Metastasis by DHA and Its Metabolite, RvD1, through miR-138-5p/FOXC1 Pathway

Addition of exogenous DHA inhibited the growth and invasion in non-small-cell lung cancer cells in vitro. Endogenously produced DHA attenuated lung cancer cell line-derived tumor growth and metastasis in the transgenic mfat-1 mice. [J Exp Clin Cancer Res] Full Article

LncRNA UCA1 Promotes Gefitinib Resistance as a ceRNA to Target FOSL2 by Sponging miR-143 in Non-Small Cell Lung Cancer

In vitro and in vivo experiments demonstrated that urothelial carcinoma-associated (UCA1) knockdown impaired cell proliferation and promoted the gefitinib-induced cell apoptosis. [Mol Ther Nucleic Acids] Abstract | Full Article

LncRNA SNHG1 Influences Cell Proliferation, Migration, Invasion, and Apoptosis of Non-Small Cell Lung Cancer Cells via the miR-361-3p/FRAT1 Axis

Small nucleolar RNA host gene 1 (SNHG1) silencing inhibited proliferation, induced apoptosis and blocked migration and invasion of non-small-cell lung cancer cells. [Thorac Cancer] Abstract

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Protein Misfolding and ER stress in Chronic Lung Disease: Will Cell-Specific Targeting be the Key to the Cure?

Scientists discuss the current understanding of endoplasmic reticulum stress and the unfolded protein response at the cellular level in the development and progression of various chronic lung diseases. [Chest] Abstract

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FDA Approves Roche’s Tecentriq Plus Chemotherapy (Abraxane and Carboplatin) for the Initial Treatment of Metastatic Non-Squamous Non-Small Cell Lung Cancer

Roche announced that the FDA approved Tecentriq^® in combination with chemotherapy for the initial treatment of adults with metastatic non-squamous non-small cell lung cancer with no EGFR or ALK genomic tumor aberrations. [Roche] Press Release

Knopp Biosciences and University of Leicester Announce Update on Planned Phase II Clinical Trial of Oral Dexpramipexole in Severe Eosinophilic Asthma

Knopp Biosciences LLC and the University of Leicester announced timelines, trial details, and eligibility criteria for a planned Phase II clinical trial evaluating the oral eosinophil-lowering drug candidate dexpramipexole in severe eosinophilic asthma patients. [Knopp Biosciences LLC] Press Release

Genkyotex Reports Progress of Setanaxib Phase II Investigator Initiated Trials

Genkyotex announced further progress in two investigator-initiated Phase II trials of setanaxib in diabetic kidney disease and idiopathic pulmonary fibrosis. [Genkyotex] Press Release

Chinese Universities with Military Ties Classed as ‘Risky’ Collaborators

Forty-three Chinese universities should be considered ‘very high’ or ‘high’ risk collaborators because of their involvement in research for military and defence purposes, according to an Australian think tank. [Nature News] Editorial

Crack Down on Genomic Surveillance

Concerns about the potential downsides of governments being able to interrogate people’s DNA have been voiced since the early 2000s by activist groups, such as the non-profit organization GeneWatch UK, and some geneticists. [Nature News] Editorial

NEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies
January 9-12, 2020
San Diego, California, United States

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NEW Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen)

Postdoctoral Fellow – Small Cell Lung Cancer (University Hospital of Cologne)

PhD Student Positions – Influenza Research (University Hospital of Muenster)

Postdoctoral Associate – Inflammation (University of Pittsburgh)

PhD Student – Organ-on-Chip (Helmholtz Zentrum München)

Postdoctoral Fellow – Pulmonary Research (Universitätsklinikum Erlangen)

Postdoctoral Fellow – Lung Cancer Epigenomics (Icahn School of Medicine at Mount Sinai)

Postdoctoral Research Fellow – Small Cell Lung Cancer (University Hospital of Cologne)

PhD Studentship – Small Cell Lung Cancer (Cancer Research UK Manchester Institute)

Postdoctoral Research Fellow – Lung Development and Disease (Center for Regenerative Medicine)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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