Pulmonary Cell News 8.47 December 5, 2019 | |
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TOP STORYEpithelial Tumor Suppressor ELF3 Is a Lineage-Specific Amplified Oncogene in Lung Adenocarcinoma The authors showed that E74 like ETS transcription factor 3 (ELF3) was an oncogene in the adenocarcinoma subtype of lung cancer, providing genetic, functional, and clinical evidence of subtype specificity. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)WNT/RYK Signaling Restricts Goblet Cell Differentiation during Lung Development and Repair RYK functioned as a WNT coreceptor, and, in the developing lung, scientists observed a high RYK expression in airway epithelial cells and moderate expression in mesenchymal cells as well as in alveolar epithelial cells. [Proc Natl Acad Sci USA] Full Article Lipid Nanoparticles Biocompatibility and Cellular Uptake in a 3D Human Lung Model Nanostructured lipid carriers (NLC) and mannosylated-NLCs were synthetized and characterized. Their uptake and biocompatibility were tested in a 3D human lung model. [Nanomedicine (Lond)] Full Article Altered Generation of Ciliated Cells in Chronic Obstructive Pulmonary Disease COPD epithelium in large airways, when compared to controls, showed decreased β-tubulin IV+ ciliated cells and increased MUC5AC+ goblet cells. Both features were recapitulated in the air-liquid interface-cultured epithelium from COPD patients. [Sci Rep] Full Article FOXO3a Regulates Rhinovirus-Induced Innate Immune Responses in Airway Epithelial Cells Researchers showed that forkhead transcription factor class O (FOXO)3a played a critical role in regulating antiviral responses as well as limiting pro-inflammatory cytokine expression. [Sci Rep] Full Article LUNG CANCERA High-Throughput Screen Identifies That CDK7 Activates Glucose Consumption in Lung Cancer Cells Scientists identified milciclib that blocked glucose consumption in H460 and H1975, but not in HCC827 or A549 cells, by decreasing SLC2A1 mRNA and protein levels and by inhibiting glucose transport. [Nat Commun] Full Article Addition of exogenous DHA inhibited the growth and invasion in non-small-cell lung cancer cells in vitro. Endogenously produced DHA attenuated lung cancer cell line-derived tumor growth and metastasis in the transgenic mfat-1 mice. [J Exp Clin Cancer Res] Full Article In vitro and in vivo experiments demonstrated that urothelial carcinoma-associated (UCA1) knockdown impaired cell proliferation and promoted the gefitinib-induced cell apoptosis. [Mol Ther Nucleic Acids] Abstract | Full Article Small nucleolar RNA host gene 1 (SNHG1) silencing inhibited proliferation, induced apoptosis and blocked migration and invasion of non-small-cell lung cancer cells. [Thorac Cancer] Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSScientists discuss the current understanding of endoplasmic reticulum stress and the unfolded protein response at the cellular level in the development and progression of various chronic lung diseases. [Chest] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSRoche announced that the FDA approved Tecentriq® in combination with chemotherapy for the initial treatment of adults with metastatic non-squamous non-small cell lung cancer with no EGFR or ALK genomic tumor aberrations. [Roche] Press Release Knopp Biosciences LLC and the University of Leicester announced timelines, trial details, and eligibility criteria for a planned Phase II clinical trial evaluating the oral eosinophil-lowering drug candidate dexpramipexole in severe eosinophilic asthma patients. [Knopp Biosciences LLC] Press Release Genkyotex Reports Progress of Setanaxib Phase II Investigator Initiated Trials Genkyotex announced further progress in two investigator-initiated Phase II trials of setanaxib in diabetic kidney disease and idiopathic pulmonary fibrosis. [Genkyotex] Press Release | |
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POLICY NEWSChinese Universities with Military Ties Classed as ‘Risky’ Collaborators Forty-three Chinese universities should be considered ‘very high’ or ‘high’ risk collaborators because of their involvement in research for military and defence purposes, according to an Australian think tank. [Nature News] Editorial Crack Down on Genomic Surveillance Concerns about the potential downsides of governments being able to interrogate people’s DNA have been voiced since the early 2000s by activist groups, such as the non-profit organization GeneWatch UK, and some geneticists. [Nature News] Editorial
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EVENTSNEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen) Postdoctoral Fellow – Small Cell Lung Cancer (University Hospital of Cologne) PhD Student Positions – Influenza Research (University Hospital of Muenster) Postdoctoral Associate – Inflammation (University of Pittsburgh) PhD Student – Organ-on-Chip (Helmholtz Zentrum München) Postdoctoral Fellow – Pulmonary Research (Universitätsklinikum Erlangen) Postdoctoral Fellow – Lung Cancer Epigenomics (Icahn School of Medicine at Mount Sinai) Postdoctoral Research Fellow – Small Cell Lung Cancer (University Hospital of Cologne) PhD Studentship – Small Cell Lung Cancer (Cancer Research UK Manchester Institute) Postdoctoral Research Fellow – Lung Development and Disease (Center for Regenerative Medicine) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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