Pulmonary Cell News Volume 8.49 | Dec 19 2019

TOP STORY

High-Efficiency, Selection-Free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia

Scientists used Cas9 and adeno-associated virus 6 to correct the ΔF508 mutation in readily accessible upper-airway basal stem cells obtained from cystic fibrosis patients. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

E-Cigarette Flavored Pods Induce Inflammation, Epithelial Barrier Dysfunction, and DNA Damage in Lung Epithelial Cells and Monocytes

Lung epithelial cells and monocytes exposed to various pod aerosols resulted in increased inflammatory mediators, such as IL-8 or PGE2. JUUL pod flavors, Crème Brulee and Cool Cucumber, caused epithelial barrier dysfunction in 16-HBE cells. [Sci Rep] Full Article

Comparative Analyses of Long Non-Coding RNA Profiles In Vivo in Cystic Fibrosis Lung Airway and Parenchyma Tissues

The authors identified 636 LncRNAs differentially expressed in cystic fibrosis (CF) airway epithelium and 1974 in CF lung parenchyma compared to matched non-CF controls, the majority of which were intergenic. [Respir Res] Full Article

LUNG CANCER

Functional Significance of U2AF1 S34F Mutations in Lung Adenocarcinomas

Investigators report a significant co-occurrence of U2AF1 S34F mutations with ROS1 translocations in lung adenocarcinomas. [Nat Commun] Full Article

Axon-Like Protrusions Promote Small Cell Lung Cancer Migration and Metastasis

Scientists showed that mouse and human small cell lung cancer cells in culture and in vivo could grow cellular protrusions that resemble axons. [eLIFE] Full Article

Hsa_Circ_0002483 Inhibited the Progression and Enhanced the Taxol Sensitivity of Non-Small Cell Lung Cancer by Targeting miR-182-5p

Functional assays indicated that circ_0002483 overexpression significantly inhibited non-small cell lung cancer (NSCLC) cell proliferation and invasion in vitro and in vivo and enhanced the sensitivity of NSCLC cells to taxol. [Cell Death Dis] Full Article

Caveolin-2 Deficiency Induces a Rapid Anti-Tumor Immune Response Prior to Regression of Implanted Murine Lung Carcinoma Tumors

Researchers demonstrated that host deficiency in caveolin-2, a member of caveolin protein family, increases M1-polarized tumor-associated macrophage and CD8 T cell infiltration into subcutaneously implanted murine lung carcinoma tumors. [Sci Rep] Full Article

TGIF2 Promotes the Progression of Lung Adenocarcinoma by Bridging EGFR/RAS/ERK Signaling to Cancer Cell Stemness

Scientists report that TGF-β-induced factor homeobox 2 (TGIF2) mediated the EGFR-RAS-ERK signaling pathway to enhance the stemness of lung adenocarcinoma (LUAD) cells and, therefore, promote the progression and metastasis of LUAD. [Signal Transduct Target Ther] Full Article

Genetically Engineered Lung Cancer Cells for Analyzing Epithelial-Mesenchymal Transition

Since EMT/MET were transitional processes, researchers generated and validated a reporter cell line. Specifically, a far-red fluorescent protein was knocked-in in-frame with the mesenchymal gene marker VIMENTIN in H2170 lung cancer cells. [Cells] Full Article

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Recent Progress in Mapping the Emerging Landscape of the Small-Cell Lung Cancer Genome

In recent years, comprehensive omics-based analyses have led to the discovery of recurrent alterations in patient tumors, and functional studies using genetically engineered mouse models and patient-derived tumor models have provided information about the alterations critical for small-cell lung cancer pathogenesis. [Exp Mol Med] Full Article

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CHMP Issues Positive Opinion to Expand CYRAMZA^® (Ramucirumab) Label to Include Results from RELAY Study in Patients with Metastatic EGFR-Mutated Non-Small Cell Lung Cancer

Eli Lilly and Company announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion recommending a new indication and associated label update for CYRAMZA^®. [Eli Lilly and Company] Press Release

Novartis Provides Update on Luster Phase III Studies in Patients with Uncontrolled GINA 4/5 Asthma

Novartis announced topline results from its pivotal global Phase III LUSTER-11 and LUSTER-22 studies exploring the efficacy and safety of the investigational oral, once-daily, DP2 receptor antagonist fevipiprant. [Novartis] Press Release

CohBar Confirms Anti-Fibrotic Effect of a Novel Peptide in a Therapeutic Model of Idiopathic Pulmonary Fibrosis

CohBar, Inc. announced new preclinical data confirming the therapeutic potential of a novel CohBar peptide in a preclinical model of idiopathic pulmonary fibrosis. [CohBar, Inc.] Press Release

NEW Advances in Liquid Biopsies
January 13-16, 2020
Miami, Florida, United States

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NEW Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital)

NEW Postdoctoral Fellow – Lung Cancer (Weill Cornell Medicine)

PhD Positions – Heart and Lung Research (International Max Planck Research School for Heart and Lung Research)

Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen)

Postdoctoral Fellow – Small Cell Lung Cancer (University Hospital of Cologne)

Postdoctoral Associate – Inflammation (University of Pittsburgh)

PhD Student – Organ-on-Chip (Helmholtz Zentrum München)

Postdoctoral Fellow – Lung Cancer Epigenomics (Icahn School of Medicine at Mount Sinai)

PhD Studentship – Small Cell Lung Cancer (Cancer Research UK Manchester Institute)

Postdoctoral Fellowship – Lung Epithelium (Boston University)

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