Pulmonary Cell News 8.49 December 19, 2019 | |
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TOP STORYScientists used Cas9 and adeno-associated virus 6 to correct the ΔF508 mutation in readily accessible upper-airway basal stem cells obtained from cystic fibrosis patients. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Lung epithelial cells and monocytes exposed to various pod aerosols resulted in increased inflammatory mediators, such as IL-8 or PGE2. JUUL pod flavors, Crème Brulee and Cool Cucumber, caused epithelial barrier dysfunction in 16-HBE cells. [Sci Rep] Full Article The authors identified 636 LncRNAs differentially expressed in cystic fibrosis (CF) airway epithelium and 1974 in CF lung parenchyma compared to matched non-CF controls, the majority of which were intergenic. [Respir Res] Full Article LUNG CANCERFunctional Significance of U2AF1 S34F Mutations in Lung Adenocarcinomas Investigators report a significant co-occurrence of U2AF1 S34F mutations with ROS1 translocations in lung adenocarcinomas. [Nat Commun] Full Article Axon-Like Protrusions Promote Small Cell Lung Cancer Migration and Metastasis Scientists showed that mouse and human small cell lung cancer cells in culture and in vivo could grow cellular protrusions that resemble axons. [eLIFE] Full Article Functional assays indicated that circ_0002483 overexpression significantly inhibited non-small cell lung cancer (NSCLC) cell proliferation and invasion in vitro and in vivo and enhanced the sensitivity of NSCLC cells to taxol. [Cell Death Dis] Full Article Researchers demonstrated that host deficiency in caveolin-2, a member of caveolin protein family, increases M1-polarized tumor-associated macrophage and CD8 T cell infiltration into subcutaneously implanted murine lung carcinoma tumors. [Sci Rep] Full Article Scientists report that TGF-β-induced factor homeobox 2 (TGIF2) mediated the EGFR-RAS-ERK signaling pathway to enhance the stemness of lung adenocarcinoma (LUAD) cells and, therefore, promote the progression and metastasis of LUAD. [Signal Transduct Target Ther] Full Article Genetically Engineered Lung Cancer Cells for Analyzing Epithelial-Mesenchymal Transition Since EMT/MET were transitional processes, researchers generated and validated a reporter cell line. Specifically, a far-red fluorescent protein was knocked-in in-frame with the mesenchymal gene marker VIMENTIN in H2170 lung cancer cells. [Cells] Full Article Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSRecent Progress in Mapping the Emerging Landscape of the Small-Cell Lung Cancer Genome In recent years, comprehensive omics-based analyses have led to the discovery of recurrent alterations in patient tumors, and functional studies using genetically engineered mouse models and patient-derived tumor models have provided information about the alterations critical for small-cell lung cancer pathogenesis. [Exp Mol Med] Full Article Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSEli Lilly and Company announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion recommending a new indication and associated label update for CYRAMZA®. [Eli Lilly and Company] Press Release Novartis Provides Update on Luster Phase III Studies in Patients with Uncontrolled GINA 4/5 Asthma Novartis announced topline results from its pivotal global Phase III LUSTER-11 and LUSTER-22 studies exploring the efficacy and safety of the investigational oral, once-daily, DP2 receptor antagonist fevipiprant. [Novartis] Press Release CohBar, Inc. announced new preclinical data confirming the therapeutic potential of a novel CohBar peptide in a preclinical model of idiopathic pulmonary fibrosis. [CohBar, Inc.] Press Release | |
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EVENTSNEW Advances in Liquid Biopsies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital) NEW Postdoctoral Fellow – Lung Cancer (Weill Cornell Medicine) Junior Research Group Leader – Lung Cancer (Justus Liebig University Giessen) Postdoctoral Fellow – Small Cell Lung Cancer (University Hospital of Cologne) Postdoctoral Associate – Inflammation (University of Pittsburgh) PhD Student – Organ-on-Chip (Helmholtz Zentrum München) Postdoctoral Fellow – Lung Cancer Epigenomics (Icahn School of Medicine at Mount Sinai) PhD Studentship – Small Cell Lung Cancer (Cancer Research UK Manchester Institute) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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