Pulmonary Cell News 9.11 March 26, 2020 | |
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TOP STORYColonization of the lungs conferred an inflammatory phenotype in metastasis-associated fibroblasts. IL-1α and IL-1β secreted by breast cancer cells induced CXCL9 and CXCL10 production in lung fibroblasts via NF-κB signaling, fueling the growth of lung metastases. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing To elucidate environmental effects on epithelial regenerative outcomes in vitro, scientists isolated and cultured a population of pharmacologically expanded basal cells from rat tracheas. [Cell Rep] Full Article | Graphical Abstract Researchers demonstrated that culture of EpCAM+ cells derived from human induced pluripotent stem cells at the physiological air-liquid interface resulted in type 2 alveolar epithelial cells-like cells with alveolar characteristics. [Sci Rep] Full Article LUNG CANCERScientists demonstrated the tumor-suppressive effect of gallic acid, which induced the decrease of programmed death-ligand 1 (PD-L1) expression through binding to epidermal growth factor receptor (EGFR) in NSCLC. [Cancers] Full Article Sea hare hydrolysates treatment inhibited the actions of M1 and M2 macrophages, which had anticancer and pro-cancer effects in non-small cell lung cancer cells and tumor-associated macrophages. [Cancers] Full Article The authors used CRISPR/Cas9 genome editing to knockout fibrinogen alpha in human lung adenocarcinoma cell lines A549 and H1299. [Mol Cancer Res] Abstract Small Nucleolar RNA Host Gene 7 (SNHG7) was found to be downregulated in lung adenocarcinoma tissues compared with normal tissues. Altered SNHG7 expression induced changes in cell proliferation and migration both in vitro and in vivo. [Am J Pathol] Abstract Cellular Processes Involved in Lung Cancer Cells Exposed to Direct Current Electric Field Researchers report the identification of electric field-sensitive genes in lung cancer cells. The gene expression profile, in which the human lung cancer CL1-0 cells were treated with a direct current electric field for two hours, was retrieved from GEO database. [Sci Rep] Full Article Hoechst 33342, a specific substrate of ATP Binding Cassette Subfamily G Member 2 (ABCG2), was used to determine the effects of Marsdenia tenacissima extract (MTE) on activities of ABCG2 in tumor cells. The activities of ABCG2, the primary drug transporter for gefitinib, were significantly inhibited by MTE in H1975 lung cancer cells. [J Ethnopharmacol] Abstract | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Cancer Stem Cell News & Human Immunology News. | |
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REVIEWSMechanisms of Ultrafine Particle-Induced Respiratory Health Effects The authors review insights into the mechanisms by which particles, including ultrafine particles, influence airway inflammation and discus several mechanisms that may explain the relationship between particulate air pollutants and human health, particularly respiratory health. [Exp Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSHuman tissue culture systems developed by STEMCELL were used by researchers at China’s Centre for Disease Control to grow lung airway cells that could successfully propagate the novel coronavirus SARS-CoV-2. [STEMCELL Technologies, Inc.] Press Release The University of Hawaii Cancer Center was awarded a five-year $2.8-million grant from the National Institute on Minority Health and Health Disparities of the National Institutes of Health, to study smoking-related lung cancer disparities across different racial and ethnic populations. [University of Hawaii] Press Release | |
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POLICY NEWSResearchers Are Tracking Another Epidemic, Too-of Misinformation When five researchers at the University of Washington, Seattle, launched the new Center for an Informed Public back in December 2019, they had no idea what was coming. The center aims to study how misinformation propagates and use the findings to “promote an informed society, and strengthen democratic discourse.” Now, just a few months later, the coronavirus pandemic is generating a tidal wave of information-some of it accurate, some not so much-that has saturated social and traditional media. [ScienceInsider] Editorial After Conference Cancellations, Some Scientists Find a Way As scores of academic meetings get upended due to COVID-19, researchers are turning to virtual replacements. [The Scientist] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Fellow – Respiratory Viruses (Queen’s University Belfast) PhD Student – Lung Cancer (University Hospital Cologne) Postdoctoral Scholar – Tumor Metabolism and DNA Repair (The Ohio State University) Postdoctoral Position – Lung Organoids (Columbia University Medical Center) Postdoctoral Research Associate – Lung Injury (University of Illinois at Chicago) Research Associate – Cystic Fibrosis (Michigan State University) Research Associate – Lung Tumors (University of Cambridge) Research Associate and Lab Manager – In Vitro Cancer Models (Flanders Institute for Biotechnology) Postdoctoral Scholar – Cancer Metabolism (The Ohio State University) Postdoctoral Position – Lung Stem Cell Research (Columbia University Medical Center) Postdoctoral Fellowship – Lung Epithelium (Boston University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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